Interaction site for the inhibition of tarantula Jingzhaotoxin-XI on voltage-gated potassium channel Kv2.1

Jingzhaotoxin-XI (JZTX-XI) is a 34-residue peptide from the Chinese tarantula Chilobrachys jingzhao venom that potently inhibits both voltage-gated sodium channel Nav1.5 and voltage-gated potassium channel Kv2.1. In the present study, we further showed that JZTX-XI blocked Kv2.1 currents with the IC...

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Bibliographic Details
Published in:	Toxicon (Oxford) Vol. 124; pp. 8 - 14
Main Authors:	Tao, Huai, Chen, Xia, Deng, Meichun, Xiao, Yucheng, Wu, Yuanyuan, Liu, Zhonghua, Zhou, Sainan, He, Yingchun, Liang, Songping
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 15-12-2016
Subjects:	Amino Acid Sequence Animals Araneae Binding Sites Channels Determinants Electric potential Jingzhaotoxin-XI Kv2.1 Molecular determinant Mutagenesis, Site-Directed Mutation Peptides - toxicity Potassium Residues Sequence Homology, Amino Acid Shab Potassium Channels - chemistry Shab Potassium Channels - drug effects Shab Potassium Channels - genetics Sodium Spider Venoms - toxicity Toxins Voltage RP-HPLC JZTX-XI MALDI-TOF IC50 Jingzhaotoxin-XI Mutation Kv2.1 WT HPLC Molecular determinant
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