Homocysteine Metabolism Pathway Is Involved in the Control of Glucose Homeostasis: A Cystathionine Beta Synthase Deficiency Study in Mouse

Cystathionine beta synthase (CBS) catalyzes the first step of the transsulfuration pathway from homocysteine to cystathionine, and its deficiency leads to hyperhomocysteinemia (HHcy) in humans and rodents. To date, scarce information is available about the HHcy effect on insulin secretion, and the l...

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Bibliographic Details
Published in:	Cells (Basel, Switzerland) Vol. 11; no. 11; p. 1737
Main Authors:	Cruciani-Guglielmacci, Céline, Meneyrol, Kelly, Denom, Jessica, Kassis, Nadim, Rachdi, Latif, Makaci, Fatna, Migrenne-Li, Stéphanie, Daubigney, Fabrice, Georgiadou, Eleni, Denis, Raphaël G, Rodriguez Sanchez-Archidona, Ana, Paul, Jean-Louis, Thorens, Bernard, Rutter, Guy A, Magnan, Christophe, Le Stunff, Hervé, Janel, Nathalie
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 25-05-2022 MDPI
Subjects:	Amino acid metabolism Analysis Animals autonomic nervous system Body composition Body weight gain Cardiovascular diseases Care and treatment Cystathionine b-synthase Cystathionine beta-Synthase - metabolism Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 Diagnosis Diet Drinking water Enzymes Food Food intake Glucose Glucose metabolism Glucose tolerance Health aspects High fat diet Homeostasis Homocysteine Homocystinuria - metabolism Hyperhomocysteinemia Hyperhomocysteinemia - metabolism Insulin Insulin resistance Insulin secretion Life Sciences Liver diseases Metabolism Methionine Mice Pancreas Parasympathetic nervous system Plasma Prevention Risk factors Secretion Thrombosis type 2 diabetes France United States > US hyperhomocysteinemia autonomic nervous system type 2 diabetes insulin secretion Animals, Glucose, Diabetes Mellitus, Type 2, insulin secretion, Mice, Homeostasis, autonomic nervous system, Cystathionine beta-Synthase, Homocysteine, Homocystinuria, hyperhomocysteinemia, Hyperhomocysteinemia, type 2 diabetes
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