Stable, polarised, functional expression of Kir1.1b channel protein in Madin-Darby canine kidney cell line

The family of Kir1.1 (ROMK) channel proteins constitute a secretory pathway for potassium in principal cells of cortical collecting duct and thick ascending limb of Henle's loop. Mutations in Kir1.1 account for some types of Bartter's syndrome. Here we report that stable transfection of Ki...

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Bibliographic Details
Published in:	The Journal of physiology Vol. 528; no. 1; pp. 5 - 13
Main Authors:	Ortega, B., Millar, I. D., Beesley, A. H., Robson, L., White, S. J.
Format:	Journal Article
Language:	English
Published:	Oxford, UK The Physiological Society 01-10-2000 Blackwell Publishing Ltd Blackwell Science Inc
Subjects:	Animals Barium - pharmacology Cell Line Cell Membrane - metabolism Cycloheximide - pharmacology Dogs Green Fluorescent Proteins Kidney - cytology Kidney - drug effects Kidney - metabolism Luminescent Proteins - genetics Original Patch-Clamp Techniques Potassium - metabolism Potassium Channel Blockers Potassium Channels - biosynthesis Potassium Channels - genetics Potassium Channels, Inwardly Rectifying Protein Synthesis Inhibitors - pharmacology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Spectrometry, Fluorescence Temperature Transfection
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