Reduced Mcm2 Expression Results in Severe Stem/Progenitor Cell Deficiency and Cancer

Mcm2 is a component of the DNA replication licensing complex that marks DNA replication origins during G1 of the cell cycle for use in the subsequent S‐phase. It is expressed in stem/progenitor cells in a variety of regenerative tissues in mammals. Here, we have used the Mcm2 gene to develop a trans...

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Bibliographic Details
Published in:	Stem cells (Dayton, Ohio) Vol. 25; no. 12; pp. 3121 - 3132
Main Authors:	Pruitt, Steven C., Bailey, Kimberly J., Freeland, Amy
Format:	Journal Article
Language:	English
Published:	Bristol John Wiley & Sons, Ltd 01-12-2007
Subjects:	Animals Base Sequence Cell Count Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - biosynthesis Cell Cycle Proteins - genetics Cellular proliferation Cre‐loxP system DNA replication licensing factor Female Gene Expression Regulation, Neoplastic - physiology Integrases - genetics Lymphoma - genetics Lymphoma - metabolism Lymphoma - mortality Lymphoma - pathology Male Mcm2 Mice Mice, Inbred C57BL Mice, Transgenic Minichromosome Maintenance Complex Component 2 Molecular Sequence Data Muscle stem cells Intestinal crypt stem cell Mutagenesis, Insertional Neural stem cell Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - biosynthesis Nuclear Proteins - deficiency Nuclear Proteins - genetics Ribosomes - genetics Ribosomes - metabolism Somatic stem cells Stem Cells - metabolism Stem Cells - pathology Stem Cells - physiology Survival Analysis
Online Access:	Get full text
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