Searching for the Bacterial Effector: The Example of the Multi-Skilled Commensal Bacterium Faecalibacterium prausnitzii

• Published in: Frontiers in microbiology Vol. 9; p. 346
• Main Authors: Martín, Rebeca, Bermúdez-Humarán, Luis G, Langella, Philippe
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media 06-03-2018; Frontiers Media S.A
• Subjects: bacterial effectors; commensal; Faecalibacterium; Life Sciences; live-biotherapeutics; Microbiology; Microbiology and Parasitology; probiotic; live-biotherapeutics; probiotic; commensal; bacterial effectors; Faecalibacterium
• ISSN: 1664-302X; 1664-302X
• DOI: 10.3389/fmicb.2018.00346

represents approximately 5% of the total fecal microbiota in healthy adults being one of the most abundant bacterium in the human intestinal microbiota of healthy adults. Furthermore, this bacterium has been proposed to be a sensor and a major actor of the human intestinal health because of its importance in the gut ecosystem. In this context,
population levels have been found to be reduced in patients suffering from several syndromes and diseases such as inflammatory bowel diseases. These diseases are characterized by a breakage of the intestinal homeostasis called dysbiosis and the use of
as a next generation probiotic (also called live biotherapeutics) has been proposed as a natural tool to restore such dysbiosis within the gut. Nevertheless, despite the potential importance of this bacterium in human health, little is known about its main effectors underlying its beneficial effects. In this perspective note, we aim to present the actual state in the research about
effectors and the future milestones in this field.