Dietary Arthrospira platensis improves systemic antioxidant potential and changes plasma lipids without affecting related hepatic metabolic pathways in post-weaned piglets

• Published in: BMC veterinary research Vol. 17; no. 1; p. 158
• Main Authors: Dos Santos Madeira, Marta Sofia Morgado, Lopes, Paula Alexandra Antunes Brás, Martins, Cátia Falcão, Assunção, José Miguel Pestana, Alfaia, Cristina Maria Riscado Pereira Mateus, Pinto, Rui Manuel Amaro, Prates, José António Mestre
• Format: Journal Article
• Language: English
• Published: England BioMed Central 13-04-2021; BMC
• Subjects: Algae; Amino acids; Animal Feed - analysis; Animal Nutritional Physiological Phenomena; Animals; Antioxidant potential; Antioxidants; Antioxidants - metabolism; Arthrospira platensis; Carbohydrates; Carotenoids; Cholesterol; Creatinine; Diet; Diet - veterinary; Dietary minerals; Discriminant analysis; Enzymes; Fatty acids; Fatty liver; Feeds; Gene expression; Hepatic lipid metabolism; Hogs; Lipid Metabolism; Lipids; Liver; Liver - metabolism; Low density lipoprotein; Lysozyme; Male; Metabolic pathways; Metabolism; Metabolites; Multienzyme Complexes - administration & dosage; Muramidase - administration & dosage; Piglets; Plasma; Principal components analysis; Proteins; Spirulina; Sus scrofa - growth & development; Sus scrofa - metabolism; Transcription; Transcription factors; Enzymes; Hepatic lipid metabolism; Arthrospira platensis; Piglets; Antioxidant potential
• ISSN: 1746-6148; 1746-6148
• DOI: 10.1186/s12917-021-02869-y

The ability of a high level of dietary Arthrospira platensis, individually or in combination with two exogenous carbohydrate-degrading enzymes (lysozyme and Rovabio
), to improve systemic antioxidant potential and hepatic lipid metabolism was tested in piglets. Forty male post-weaned piglets, sons of Large White × Landrace sows crossed with Pietrain boars, were allocated into 4 groups (n = 10) and fed during 28 days one of the following diets: 1) a control basal diet (cereal and soybean meal); 2) a basal diet with 10% of A. platensis (AP); 3) the AP diet supplemented with 0.005% of Rovabio
(AP + R); 4) the AP diet supplemented with 0.01% of lysozyme (AP + L).
Arthrospira platensis decreased BW gain of piglets, regardless the addition of feed enzymes. The majority of plasma metabolites were affected by diets. A. platensis increased total lipids, total cholesterol and LDL-cholesterol, without changing hepatic fatty acid content or modulating, in an expressive manner, the transcriptional profile of lipid sensitive mediators. The antioxidant potential in general, and total carotenoids in particular, were improved by the microalga, regardless lysozyme or Rovabio
.
Summing up, A. platensis, individually and combined with feed enzymes, impacts negatively on piglets' growth but improves the systemic antioxidant potential and changes plasma lipids with a minor modulation on related hepatic metabolic pathways.