Cytoplasmic dynein nucleates microtubules to organize them into radial arrays in vivo
Numerous evidence demonstrates that dynein is crucial for organization of microtubules (MTs) into radial arrays, but its exact function in this process is unclear. Here, we studied the role of cytoplasmic dynein in MT radial array formation in the absence of the centrosome. We found that dynein is a...
Saved in:
| Published in: | Molecular biology of the cell Vol. 15; no. 6; pp. 2742 - 2749 |
|---|---|
| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
The American Society for Cell Biology
01-06-2004
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Numerous evidence demonstrates that dynein is crucial for organization of microtubules (MTs) into radial arrays, but its exact function in this process is unclear. Here, we studied the role of cytoplasmic dynein in MT radial array formation in the absence of the centrosome. We found that dynein is a potent MT nucleator in vitro and that stimulation of dynein activity in cytoplasmic fragments of melanophores induces nucleation-dependent formation of MT radial array in the absence of the centrosome. This new property of dynein, in combination with its known role as an MT motor that is essential for MT array organization in the absence and presence of the centrosome, makes it a unique molecule whose activity is necessary and sufficient for the formation and maintenance of MT radial arrays in cells. |
|---|---|
| AbstractList | Numerous evidence demonstrates that dynein is crucial for organization of microtubules (MTs) into radial arrays, but its exact function in this process is unclear. Here, we studied the role of cytoplasmic dynein in MT radial array formation in the absence of the centrosome. We found that dynein is a potent MT nucleator in vitro and that stimulation of dynein activity in cytoplasmic fragments of melanophores induces nucleation-dependent formation of MT radial array in the absence of the centrosome. This new property of dynein, in combination with its known role as an MT motor that is essential for MT array organization in the absence and presence of the centrosome, makes it a unique molecule whose activity is necessary and sufficient for the formation and maintenance of MT radial arrays in cells. |
| Author | Malikov, Viacheslav Rodionov, Vladimir Kashina, Anna |
| AuthorAffiliation | Department of Physiology and Center for Biomedical Imaging Technology, University of Connecticut Health Center, Farmington, Connecticut 06032-1507 |
| AuthorAffiliation_xml | – name: Department of Physiology and Center for Biomedical Imaging Technology, University of Connecticut Health Center, Farmington, Connecticut 06032-1507 |
| Author_xml | – sequence: 1 givenname: Viacheslav surname: Malikov fullname: Malikov, Viacheslav organization: Department of Physiology and Center for Biomedical Imaging Technology, University of Connecticut Health Center, Farmington, Connecticut 06032-1507, USA – sequence: 2 givenname: Anna surname: Kashina fullname: Kashina, Anna – sequence: 3 givenname: Vladimir surname: Rodionov fullname: Rodionov, Vladimir |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15047865$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFUT1v3DAMFYoUzUc7dys8dXNCWpJlDh2KQ_oBBOjSzILsoxMVtnSV7AMuv7465NCPqRPJx_cIku9SnIUYWIi3CNcIhDdzP1zfgqwRajAGXogLJEm10l17VnLQVKNu1Lm4zPkHACrVmlfiHDUo07X6QtxvDkvcTS7Pfqi2h8A-VGEdJnYL56qAKS5rv06lWGIV04ML_omr5ZHnyocCJbf1bqpcSu6QC1Tt_T6-Fi9HN2V-c4pX4v7T7ffNl_ru2-evm4939aCoXWrXa0bsUA3S9B30DbEhZNOMo-6M1BqlU4jb0Y1Dg8R6bKmjVinqHRFLeSU-PM_drf3M24HDktxkd8nPLh1sdN7-2wn-0T7EvVUNAHVF__6kT_Hnynmxs88DT5MLHNdsDZJBbeC_RKTWEMjjRjfPxPK4nBOPv5dBsEfLbLHMMshjfbSsKN79fcMf_skj-QvFhJZP |
| CitedBy_id | crossref_primary_10_1016_j_mcn_2011_05_004 crossref_primary_10_1021_acsnano_1c04435 crossref_primary_10_1134_S1990519X08060035 crossref_primary_10_1146_annurev_cellbio_101011_155711 crossref_primary_10_1091_mbc_e07_10_1069 crossref_primary_10_1134_S1990747810030013 crossref_primary_10_1016_j_devcel_2007_08_022 crossref_primary_10_1103_PhysRevLett_107_218103 crossref_primary_10_1091_mbc_e05_04_0360 crossref_primary_10_1134_S1062360406050018 crossref_primary_10_1091_mbc_e08_09_0909 crossref_primary_10_1002_cbin_10492 crossref_primary_10_1111_j_1600_0854_2007_00698_x crossref_primary_10_1016_j_devcel_2007_04_002 crossref_primary_10_1083_jcb_200505071 crossref_primary_10_1371_journal_pone_0016127 crossref_primary_10_1091_mbc_e06_12_1156 crossref_primary_10_1038_ncb1332 crossref_primary_10_1063_1_4807909 crossref_primary_10_1242_jcs_02302 crossref_primary_10_1016_j_molbiopara_2005_04_017 crossref_primary_10_1038_s41598_016_0030_3 crossref_primary_10_1038_cdd_2012_61 crossref_primary_10_1091_mbc_E23_10_0407 crossref_primary_10_1242_dev_095612 crossref_primary_10_1111_j_1600_0854_2009_00880_x crossref_primary_10_1242_jcs_048777 crossref_primary_10_1111_tra_12385 crossref_primary_10_3852_15_323 crossref_primary_10_1134_S0006297907110090 crossref_primary_10_1007_s00418_013_1119_4 crossref_primary_10_1080_00048670802203467 crossref_primary_10_1016_j_jplph_2014_10_023 crossref_primary_10_1091_mbc_e08_12_1160 crossref_primary_10_1016_j_ceb_2012_05_011 crossref_primary_10_1016_j_pneurobio_2011_08_003 crossref_primary_10_1140_epje_i2010_10548_8 |
| Cites_doi | 10.1126/science.1059758 10.1093/emboj/18.23.6786 10.1083/jcb.149.4.851 10.1083/jcb.147.6.1261 10.1083/jcb.147.2.321 10.1073/pnas.92.5.1634 10.1083/jcb.138.5.1055 10.1038/38532 10.1091/mbc.11.6.2047 10.1073/pnas.72.5.1858 10.1083/jcb.138.5.953 10.1083/jcb.126.6.1455 10.1016/S0960-9822(00)00406-1 10.1083/jcb.200305082 10.1073/pnas.93.12.5975 10.1038/386170a0 10.1038/35014051 10.1038/295701a0 10.1002/cm.970090205 10.1016/S0301-4622(01)00197-1 10.1016/0076-6879(91)96017-L 10.1038/71338 10.1038/382420a0 10.1006/bbrc.1999.0572 10.1083/jcb.200204109 10.1126/science.1063488 10.1073/pnas.181354198 10.1074/jbc.M000688200 10.1111/j.1749-6632.1975.tb19196.x 10.1016/S0091-679X(01)67004-3 10.1242/jcs.111.11.1477 10.1016/S0091-679X(08)60852-3 10.1016/S0091-679X(08)60164-8 10.1038/35089575 10.1083/jcb.134.2.455 10.1016/j.cub.2003.10.027 10.1083/jcb.132.4.617 10.1016/S0076-6879(98)98017-X 10.1073/pnas.76.9.4350 10.1083/jcb.200203089 10.1016/S0960-9822(98)70064-8 10.1111/j.1600-0749.1999.tb00762.x 10.1146/annurev.cb.02.110186.002225 |
| ContentType | Journal Article |
| Copyright | Copyright © 2004, The American Society for Cell Biology 2004 |
| Copyright_xml | – notice: Copyright © 2004, The American Society for Cell Biology 2004 |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 8FD FR3 P64 RC3 7X8 5PM |
| DOI | 10.1091/mbc.E03-10-0770 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Genetics Abstracts Engineering Research Database Technology Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE MEDLINE - Academic Genetics Abstracts |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1939-4586 |
| EndPage | 2749 |
| ExternalDocumentID | 10_1091_mbc_e03_10_0770 15047865 |
| Genre | Research Support, U.S. Gov't, P.H.S Journal Article |
| GrantInformation_xml | – fundername: NIGMS NIH HHS grantid: R01 GM062290 – fundername: NIGMS NIH HHS grantid: GM-62290 |
| GroupedDBID | --- .GJ 123 18M 29M 2WC 34G 39C 3O- 4.4 53G 5RE 5VS ABDNZ ABSQV ACGFO ACYGS ADBBV ADDZX ADNWM AEILP AENEX AFFNX AFHIN AFOSN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL C1A CGR CS3 CUY CVF D0L DIK DU5 E3Z EBS ECM EIF EJD F5P F9R GX1 H13 HH5 HYE IAO IGS IH2 IHR INIJC ITC KQ8 NPM OHT OK1 R0Z RHF RPM SJN TCB TR2 VQA W8F WOQ YHG YKV YNT YQT YWH ZGI ZXP AAYXX CITATION 8FD FR3 P64 RC3 7X8 5PM |
| ID | FETCH-LOGICAL-c496t-ab5e11814c37b80b29e791e72ff58735513a411dfafc219e5f69896449ba99e33 |
| IEDL.DBID | RPM |
| ISSN | 1059-1524 |
| IngestDate | Tue Sep 17 21:23:22 EDT 2024 Fri Oct 25 10:13:31 EDT 2024 Sun Sep 29 07:18:26 EDT 2024 Thu Nov 21 23:12:08 EST 2024 Sat Sep 28 08:49:10 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c496t-ab5e11814c37b80b29e791e72ff58735513a411dfafc219e5f69896449ba99e33 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Corresponding author. E-mail address: rodionov@nso.uchc.edu. Article published online ahead of print. Mol. Biol. Cell 10.1091/mbc.E03-10-0770. Article and publication date are available at www.molbiolcell.org/cgi/doi/10.1091/mbc.E03-10-0770. |
| OpenAccessLink | https://europepmc.org/articles/pmc420098?pdf=render |
| PMID | 15047865 |
| PQID | 19679033 |
| PQPubID | 23462 |
| PageCount | 8 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_420098 proquest_miscellaneous_71971570 proquest_miscellaneous_19679033 crossref_primary_10_1091_mbc_e03_10_0770 pubmed_primary_15047865 |
| PublicationCentury | 2000 |
| PublicationDate | 2004-Jun 2004-06-00 20040601 |
| PublicationDateYYYYMMDD | 2004-06-01 |
| PublicationDate_xml | – month: 06 year: 2004 text: 2004-Jun |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Molecular biology of the cell |
| PublicationTitleAlternate | Mol Biol Cell |
| PublicationYear | 2004 |
| Publisher | The American Society for Cell Biology |
| Publisher_xml | – name: The American Society for Cell Biology |
| References | 10764751 - J Biol Chem. 2000 Jul 21;275(29):21975-80 10753740 - Curr Biol. 2000 Apr 6;10(7):R276-8 10854327 - Nat Cell Biol. 2000 Jun;2(6):358-64 9580556 - J Cell Sci. 1998 Jun;111 ( Pt 11):1477-81 3548773 - Annu Rev Cell Biol. 1986;2:421-57 388439 - Proc Natl Acad Sci U S A. 1979 Sep;76(9):4350-4 1056738 - Ann N Y Acad Sci. 1975 Jun 30;253:107-32 9443917 - Curr Biol. 1998 Jan 29;8(3):165-8 10541038 - Pigment Cell Res. 1999 Oct;12(5):283-94 9062188 - Nature. 1997 Mar 13;386(6621):170-3 11550480 - Methods Cell Biol. 2001;67:43-51 8707829 - J Cell Biol. 1996 Jul;134(2):455-64 10811826 - J Cell Biol. 2000 May 15;149(4):851-62 11504928 - Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10160-5 11527585 - Biophys Chem. 2001 Aug 30;92(1-2):127-39 9281583 - J Cell Biol. 1997 Sep 8;138(5):1055-66 12391026 - J Cell Biol. 2002 Oct 28;159(2):245-54 8089178 - J Cell Biol. 1994 Sep;126(6):1455-64 10620802 - Nat Cell Biol. 2000 Jan;2(1):20-4 12975343 - J Cell Biol. 2003 Sep 15;162(6):963-9 14588239 - Curr Biol. 2003 Oct 28;13(21):1837-47 7476536 - Methods Cell Biol. 1995;47:503-6 10525538 - J Cell Biol. 1999 Oct 18;147(2):321-34 8684481 - Nature. 1996 Aug 1;382(6590):420-5 9281574 - J Cell Biol. 1997 Sep 8;138(5):953-6 2965993 - Cell Motil Cytoskeleton. 1988;9(2):129-39 9751880 - Methods Enzymol. 1998;298:171-84 10222231 - Biochem Biophys Res Commun. 1999 Apr 29;258(1):39-43 11641489 - Science. 2001 Oct 19;294(5542):543-7 9305848 - Nature. 1997 Sep 18;389(6648):305-8 10848628 - Mol Biol Cell. 2000 Jun;11(6):2047-56 8650204 - Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5975-9 12235119 - J Cell Biol. 2002 Sep 16;158(6):997-1003 7878030 - Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1634-8 10601339 - J Cell Biol. 1999 Dec 13;147(6):1261-74 11533726 - Nat Rev Mol Cell Biol. 2001 Sep;2(9):688-98 6460193 - Nature. 1982 Feb 25;295(5851):701-3 10581251 - EMBO J. 1999 Dec 1;18(23):6786-92 1057175 - Proc Natl Acad Sci U S A. 1975 May;72(5):1858-62 8246791 - Methods Cell Biol. 1993;39:105-13 11349149 - Science. 2001 May 11;292(5519):1167-71 1827861 - Methods Enzymol. 1991;196:175-81 8647893 - J Cell Biol. 1996 Feb;132(4):617-33 REF9 REF7 REF8 REF5 REF6 REF3 REF4 REF40 REF22 REF21 REF43 REF20 REF42 REF41 REF26 REF25 REF24 REF23 REF29 REF28 REF27 REF11 REF33 REF10 REF32 REF31 REF30 REF15 REF37 REF14 REF36 REF13 REF35 REF12 REF34 REF1 REF19 REF2 REF18 REF17 REF39 REF16 REF38 |
| References_xml | – ident: REF36 doi: 10.1126/science.1059758 – ident: REF20 doi: 10.1093/emboj/18.23.6786 – ident: REF25 doi: 10.1083/jcb.149.4.851 – ident: REF22 doi: 10.1083/jcb.147.6.1261 – ident: REF28 doi: 10.1083/jcb.147.2.321 – ident: REF40 doi: 10.1073/pnas.92.5.1634 – ident: REF9 doi: 10.1083/jcb.138.5.1055 – ident: REF26 doi: 10.1038/38532 – ident: REF43 doi: 10.1091/mbc.11.6.2047 – ident: REF41 doi: 10.1073/pnas.72.5.1858 – ident: REF24 doi: 10.1083/jcb.138.5.953 – ident: REF33 doi: 10.1083/jcb.126.6.1455 – ident: REF15 doi: 10.1016/S0960-9822(00)00406-1 – ident: REF4 doi: 10.1083/jcb.200305082 – ident: REF8 doi: 10.1073/pnas.93.12.5975 – ident: REF31 doi: 10.1038/386170a0 – ident: REF42 doi: 10.1038/35014051 – ident: REF1 doi: 10.1038/295701a0 – ident: REF11 doi: 10.1002/cm.970090205 – ident: REF13 doi: 10.1016/S0301-4622(01)00197-1 – ident: REF10 doi: 10.1016/0076-6879(91)96017-L – ident: REF19 doi: 10.1038/71338 – ident: REF12 doi: 10.1038/382420a0 – ident: REF16 doi: 10.1006/bbrc.1999.0572 – ident: REF30 doi: 10.1083/jcb.200204109 – ident: REF17 doi: 10.1126/science.1063488 – ident: REF39 doi: 10.1073/pnas.181354198 – ident: REF21 doi: 10.1074/jbc.M000688200 – ident: REF3 doi: 10.1111/j.1749-6632.1975.tb19196.x – ident: REF34 doi: 10.1016/S0091-679X(01)67004-3 – ident: REF5 doi: 10.1242/jcs.111.11.1477 – ident: REF18 doi: 10.1016/S0091-679X(08)60852-3 – ident: REF14 doi: 10.1016/S0091-679X(08)60164-8 – ident: REF6 doi: 10.1038/35089575 – ident: REF23 doi: 10.1083/jcb.134.2.455 – ident: REF35 doi: 10.1016/j.cub.2003.10.027 – ident: REF7 doi: 10.1083/jcb.132.4.617 – ident: REF2 doi: 10.1016/S0076-6879(98)98017-X – ident: REF37 doi: 10.1073/pnas.76.9.4350 – ident: REF29 doi: 10.1083/jcb.200203089 – ident: REF32 doi: 10.1016/S0960-9822(98)70064-8 – ident: REF38 doi: 10.1111/j.1600-0749.1999.tb00762.x – ident: REF27 doi: 10.1146/annurev.cb.02.110186.002225 |
| SSID | ssj0014467 |
| Score | 2.0121949 |
| Snippet | Numerous evidence demonstrates that dynein is crucial for organization of microtubules (MTs) into radial arrays, but its exact function in this process is... |
| SourceID | pubmedcentral proquest crossref pubmed |
| SourceType | Open Access Repository Aggregation Database Index Database |
| StartPage | 2742 |
| SubjectTerms | Animals Cells, Cultured Dynactin Complex Dyneins - metabolism Fish Proteins - chemistry Fish Proteins - metabolism Fishes Kinesin - metabolism Melanophores - cytology Melanophores - metabolism Microtubule-Associated Proteins - metabolism Microtubules - chemistry Microtubules - metabolism Swine Tubulin - metabolism |
| Title | Cytoplasmic dynein nucleates microtubules to organize them into radial arrays in vivo |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/15047865 https://search.proquest.com/docview/19679033 https://search.proquest.com/docview/71971570 https://pubmed.ncbi.nlm.nih.gov/PMC420098 |
| Volume | 15 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JbtswECVqAwVyCbomTrrw0EMvsiSTEsVj4QXuIUbR1kFuAkmPUAERZdhSAf19OFpap0UvPUqituGA80i-eUPIB6MBVXulF88yN0GJYunpWAsvi3EJQ8-SBDAbef1NbO6SxRJlcviQC9OS9o3Op_a-mNr8R8ut3BfGH3hi_pebOccl_cQfkZGDhsMMvd85cNObtqCKgw2ei018kPORoV9oM132VCwh2hpwEYrTYGA5DUp_Ic0_CZMnEWj1jJz30JF-6j7xOXkC9gV52hWTbF6S7bypyr0Dw0Vu6KKxkFu6QbViRJP0Bol3Va1r93O0KmmfgwnU-UlBc-tOfUWZAnz-QTVH-tnS2_xn-YpsV8vv87XXF03wDJdx5SkdASaTcsOETgI9kyBkCGKWZVEiGNZzUTwMd5nKjButIMqwhKRDRVIrKYGx12RsSwuXhMpEK9dMaRMAlzsug53KokgYziAIgE3Ix8Fq6b7Txki7Pe0wdbZOIWB4jLaekPeDVVPnv7gpoSyU9TF1I4CQAWP_biFCKcIIn3HR9cLvl_XdNyHxo_751QC1sx9fcS7Vamh3LnT1vzdek7OOwoPLMW_IuDrU8JaMjrv6XeuODzDV5XU |
| link.rule.ids | 230,315,729,782,786,887,27933,27934,53800,53802 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JbtswEB1kQdFemu51kzY89NCLbMqkRPEYOA4cNDaKLEVvAklTqICKMmKpgP--HC3ZilxylEhRhB7FGZJv3gB8Ndqiaq8M4nHmFyhRLAMdaxFkMW5h6HGSWIxGnl2Ixa_keIoyObyPhWlI-0bnQ_enGLr8d8OtXBVm1PPERj_mE45b-sloG3b970ppv0bvzg78AqdJqeIdh8BbJ94L-shwVGgznHZkLCGaLHARytOgablrlv7zNR9SJu_YoJO9p_X-FbzsfE5y1Ja-hi3r3sCzNgvl5i1cTTZVufJedJEbcrxxNndkgTLH6IaSOTL2qlrXvl1SlaQL3rTED7CC5M7fOkd9A2z_Wm3W5NSRn_nf8h1cnUwvJ7Ogy7YQGC7jKlA6shiFyg0TOqF6LK2QoRXjLIsSwTARjOJhuMxUZvw0Z6MMc096d0pqJaVl7D3suNLZj0BkopWvprShlssll3SpsigShjNLqWUD-NZ_7HTVimqk7WF4mHqIUksZXiNEAzjswUj9wMfTDOVsWa9TP3UISRl7vIYIpQgjbONDC97tyzrUBxDfg_WmAopu3y_xaDbi2y16n5764CE8n13Oz9Kz08X3fXjR8oBwT-cAdqrr2n6G7fWy_tKM6H-aBvrD |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZoq1ZcoJQCS4H6wIFLNg8ncXxE-1Ar6KoCirhFtjNWIxFn1U2Q9t_jyaO0IC49Jpk4Sj47M7a_-YaQ91oBqvYKL42Mm6AkqfBUqrhnUlzCUFGWAWYjn33lqx_ZfIEyOdmYC9OR9rUqp_ZnNbXldcetXFfaH3li_uXFLMYl_cxfF8bfIXtuyAbROE8f9g_cJKcrq-KCB895qHgU9RGhXyk9XQyELM67SnAJStSge7nrmv6JN_-mTd7xQ8unD3-DQ_JkiD3px97iGXkE9ojs99Uot8_J1Wzb1GsXTVelpvOthdLSFcodYzhKL5C517SqdW3TpqZDEidQ19EqWlp36gvqHGD7N3K7oeeWfi9_1cfkarn4NjvzhqoLno5F2nhSJYDZqLFmXGWBigRwEQKPjEkyzrAgjIzDsDDSaPe7g8RgDUoXVgklhQDGXpBdW1t4RajIlHRmUukAYlHEIiikSRKuYwZBAGxCPowfPF_34hp5vyke5g6mHAKGxwjThJyOgORuAOCuhrRQt5vc_UK4CBj7vwUPBQ8TbONlD-Cfhw3IT0h6D9pbAxTfvn_FIdqJcPcIvn7ojafk4HK-zD-frz6dkMc9HQiXdt6Q3eamhbdkZ1O077pO_RuA6_1D |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cytoplasmic+dynein+nucleates+microtubules+to+organize+them+into+radial+arrays+in+vivo&rft.jtitle=Molecular+biology+of+the+cell&rft.au=Malikov%2C+Viacheslav&rft.au=Kashina%2C+Anna&rft.au=Rodionov%2C+Vladimir&rft.date=2004-06-01&rft.issn=1059-1524&rft.volume=15&rft.issue=6&rft.spage=2742&rft.epage=2749&rft_id=info:doi/10.1091%2Fmbc.E03-10-0770&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1059-1524&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1059-1524&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1059-1524&client=summon |