Short-term Prophylaxis for Delivery in Pregnant Women with Hereditary Angioedema with Normal C1-Inhibitor

• Published in: Revista Brasileira de ginecologia e obstetrícia Vol. 42; no. 12; pp. 845 - 848
• Main Authors: Moraes, Caroline Guth de Freitas Batista de, Mikami, Liya Regina, Ferrari, Lilian Pereira, Pesquero, João Bosco, Chong-Neto, Herberto José, Rosario Filho, Nelson Augusto
• Format: Journal Article
• Language: English
• Published: Brazil Thieme Revinter Publicações Ltda 01-12-2020; Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
• Subjects: Adult; angioedema; Angioedemas, Hereditary - diagnosis; Case Report; Cesarean Section; Diagnosis, Differential; edema; estrogens; Factor XII - genetics; Female; Humans; OBSTETRICS & GYNECOLOGY; Pedigree; Pregnancy; Pregnancy Complications - diagnosis; Prenatal Diagnosis; prophylaxis; Young Adult; angioedema; edema; gravidez; pregnancy; estrogens; estrogênios; prophylaxis; profilaxia
• ISSN: 0100-7203; 1806-9339; 1806-9339
• DOI: 10.1055/s-0040-1718955

To verify the efficacy of short-term prophylaxis for vaginal or cesarean section childbirth with plasma-derived C1-inhibitor concentrate in pregnant women. They should have hereditary angioedema (HAE) and normal plasma C1-inhibitor.
 Case report of pregnant women diagnosed with HAE with normal C1-inhibitor who had been treated with intravenous C1-inhibitor concentrate for prophylaxis of angioedema attacks when hospitalized for delivery. The exon 9 of the Factor 12 (
) genotyping gene was performed by automatic sequencing in all patients.
 Three cases of pregnant women with HAE with normal serum level of C1-inhibitor are reported. The genetic test detected the presence of a pathogenic mutation in the
gene. Deliveries occurred uneventfully and patients had no HAE symptoms in the following 72 hours.
 C1-inhibitor concentrate could be useful to prevent angioedema attacks during and after delivery.