Inhibitory role of diazepam on autoimmune inflammation in rats with experimental autoimmune encephalomyelitis

Abstract Glutamate and GABA are the main excitatory and inhibitory neurotransmitters in the CNS, and both may be involved in the neuronal dysfunction in neurodegenerative conditions. We have recently found that glutamate release was decreased in isolated synaptosomes from the rat cerebral cortex dur...

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Bibliographic Details
Published in:	Neuroscience Vol. 199; pp. 421 - 428
Main Authors:	Bibolini, M.J, Chanaday, N.L, Báez, N.S, Degano, A.L, Monferran, C.G, Roth, G.A
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Ltd 29-12-2011 Elsevier
Subjects:	Animal models Animals autoimmunity Autoimmunity - drug effects Autoimmunity - immunology Biological and medical sciences Cerebrospinal fluid. Meninges. Spinal cord diazepam Diazepam - pharmacology Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Fundamental and applied biological sciences. Psychology GABA Agonists - pharmacology GABAergic system Inflammation - immunology Inflammation - pathology Medical sciences multiple sclerosis Nervous system (semeiology, syndromes) Neurology neurotransmitter release Rats Rats, Wistar Synaptic Transmission - drug effects Synaptic Transmission - immunology Synaptosomes - drug effects Synaptosomes - immunology Synaptosomes - pathology Vertebrates: nervous system and sense organs complete Freund's adjuvant MNC stimulation index diazepam concanavalin A phosphate-buffered saline neurotransmitter release mononuclear cells 4-aminopyridine experimental autoimmune encephalomyelitis GABAergic system SI MBP dpi PBS APCs antigen-presenting cells 4AP multiple sclerosis MS Con A EAE days post-induction myelin basic protein delayed-type hypersensitivity autoimmunity DTH CFA Nervous system diseases Encephalomyelitis Rat Rodentia Inflammation Cerebral disorder Vertebrata Mammalia Animal Central nervous system disease Neurotransmitter Spinal cord disease Diazepam Release
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