Screening of antiplasmodial efficacy of Ajuga bracteosa Wall ex. Benth
The rising problem of Plasmodium resistance to the classical antimalarial drugs stresses the need to look for newer antiplasmodial components with effective and new mode of action. In the present study, the traditional medicinal plant Ajuga bracteosa has been screened for its antiplasmodial efficacy...
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| Published in: | Parasitology research (1987) Vol. 108; no. 4; pp. 801 - 805 |
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| Format: | Journal Article |
| Language: | English |
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| Abstract | The rising problem of Plasmodium resistance to the classical antimalarial drugs stresses the need to look for newer antiplasmodial components with effective and new mode of action. In the present study, the traditional medicinal plant Ajuga bracteosa has been screened for its antiplasmodial efficacy. The extract was found to possess significant in vitro antiplasmodial efficacy with an IC₅₀ of 10.0 μg/ml. Thus, the extract was further evaluated for its in vivo schizontocidal activity and efficacy in terms of survival time in Plasmodium berghei infected BALB/c mice. The extract at 250, 500, and 750 mg/kg/day exhibited significant (p < 0.0001) blood schizontocidal activity during established infection with enhanced mean survival time comparable to that of standard drug chloroquine, 5 mg/kg/day. The significant schizontocidal activity and enhanced mean survival time of mice stress the need to identify and characterize active antiplasmodial principle from this plant. |
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| AbstractList | The rising problem of
Plasmodium
resistance to the classical antimalarial drugs stresses the need to look for newer antiplasmodial components with effective and new mode of action. In the present study, the traditional medicinal plant
Ajuga bracteosa
has been screened for its antiplasmodial efficacy. The extract was found to possess significant in vitro antiplasmodial efficacy with an IC
50
of 10.0 μg/ml. Thus, the extract was further evaluated for its in vivo schizontocidal activity and efficacy in terms of survival time in
Plasmodium berghei
infected BALB/c mice. The extract at 250, 500, and 750 mg/kg/day exhibited significant (
p
< 0.0001) blood schizontocidal activity during established infection with enhanced mean survival time comparable to that of standard drug chloroquine, 5 mg/kg/day. The significant schizontocidal activity and enhanced mean survival time of mice stress the need to identify and characterize active antiplasmodial principle from this plant. The rising problem of Plasmodium resistance to the classical antimalarial drugs stresses the need to look for newer antiplasmodial components with effective and new mode of action. In the present study, the traditional medicinal plant Ajuga bracteosa has been screened for its antiplasmodial efficacy. The extract was found to possess significant in vitro antiplasmodial efficacy with an [IC.sub.50] of 10.0 µg/ml. Thus, the extract was further evaluated for its in vivo schizontocidal activity and efficacy in terms of survival time in Plasmodium berghei infected BALB/c mice. The extract at 250, 500, and 750 mg/kg/day exhibited significant (p<0.0001) blood schizontocidal activity during established infection with enhanced mean survival time comparable to that of standard drug chloroquine, 5 mg/kg/day. The significant schizontocidal activity and enhanced mean survival time of mice stress the need to identify and characterize active antiplasmodial principle from this plant. The rising problem of Plasmodium resistance to the classical antimalarial drugs stresses the need to look for newer antiplasmodial components with effective and new mode of action. In the present study, the traditional medicinal plant Ajuga bracteosa has been screened for its antiplasmodial efficacy. The extract was found to possess significant in vitro antiplasmodial efficacy with an IC50 of 10.0 Delta *mg/ml. Thus, the extract was further evaluated for its in vivo schizontocidal activity and efficacy in terms of survival time in Plasmodium berghei infected BALB/c mice. The extract at 250, 500, and 750 mg/kg/day exhibited significant (p<0.0001) blood schizontocidal activity during established infection with enhanced mean survival time comparable to that of standard drug chloroquine, 5 mg/kg/day. The significant schizontocidal activity and enhanced mean survival time of mice stress the need to identify and characterize active antiplasmodial principle from this plant. The rising problem of Plasmodium resistance to the classical antimalarial drugs stresses the need to look for newer antiplasmodial components with effective and new mode of action. In the present study, the traditional medicinal plant Ajuga bracteosa has been screened for its antiplasmodial efficacy. The extract was found to possess significant in vitro antiplasmodial efficacy with an IC₅₀ of 10.0 μg/ml. Thus, the extract was further evaluated for its in vivo schizontocidal activity and efficacy in terms of survival time in Plasmodium berghei infected BALB/c mice. The extract at 250, 500, and 750 mg/kg/day exhibited significant (p < 0.0001) blood schizontocidal activity during established infection with enhanced mean survival time comparable to that of standard drug chloroquine, 5 mg/kg/day. The significant schizontocidal activity and enhanced mean survival time of mice stress the need to identify and characterize active antiplasmodial principle from this plant. The rising problem of Plasmodium resistance to the classical antimalarial drugs stresses the need to look for newer antiplasmodial components with effective and new mode of action. In the present study, the traditional medicinal plant Ajuga bracteosa has been screened for its antiplasmodial efficacy. The extract was found to possess significant in vitro antiplasmodial efficacy with an IC(50) of 10.0 μg/ml. Thus, the extract was further evaluated for its in vivo schizontocidal activity and efficacy in terms of survival time in Plasmodium berghei infected BALB/c mice. The extract at 250, 500, and 750 mg/kg/day exhibited significant (p<0.0001) blood schizontocidal activity during established infection with enhanced mean survival time comparable to that of standard drug chloroquine, 5 mg/kg/day. The significant schizontocidal activity and enhanced mean survival time of mice stress the need to identify and characterize active antiplasmodial principle from this plant. |
| Audience | Academic |
| Author | Bagai, Upma Chandel, Sanjeev |
| Author_xml | – sequence: 1 fullname: Chandel, Sanjeev – sequence: 2 fullname: Bagai, Upma |
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| Cites_doi | 10.1007/s00436-008-0977-5 10.1300/J044v13n01_09 10.1007/s00436-007-0821-3 10.1172/JCI33996 10.1016/S0378-8741(03)00277-0 10.1128/IAI.69.1.123-128.2001 10.1055/s-1999-14053 10.1007/s00436-003-0859-9 10.1016/S1286-4579(01)01523-4 10.1007/s11101-005-3261-7 10.1080/713610851 10.1016/S0378-8741(02)00327-6 10.1016/j.bcp.2004.05.049 10.1179/136485906X118512 10.2174/092986706775476043 10.1097/00042737-199612000-00018 10.1016/j.jep.2004.03.026 10.1126/science.781840 10.1021/np0104626 10.1007/s00436-006-0369-7 10.1080/00034983.1970.11686683 10.5962/bhl.title.137025 |
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| Keywords | Plasmodium Berghei Antiplasmodial Activity Negative Control Group Chloroquine Artemisinin Parasite Wall |
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| SubjectTerms | Ajuga Ajuga - chemistry Analysis Animals Antimalarials Antimalarials - isolation & purification Antimalarials - pharmacology Biological and medical sciences Biomedical and Life Sciences Biomedicine Dehydroepiandrosterone Disease Models, Animal Dosage and administration Drug Evaluation, Preclinical Drug resistance Fundamental and applied biological sciences. Psychology General aspects General aspects and techniques. Study of several systematic groups. Models Hormones, Sex Immunology Inhibitory Concentration 50 Invertebrates Malaria Malaria - drug therapy Medical Microbiology Medicine, Botanic Medicine, Herbal Mice Mice, Inbred BALB C Microbiology Original Paper Parasitic diseases Phytosterols Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant lipids Plant metabolites Plants Plasmodium berghei Plasmodium berghei - drug effects Plasmodium falciparum Rodent Diseases - drug therapy Survival Analysis Treatment Outcome |
| Title | Screening of antiplasmodial efficacy of Ajuga bracteosa Wall ex. Benth |
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