The Effect of Testosterone Replacement on Intramedullary, Inguinal and Visceral Fat in Ovariectomized Rats
The present article aims to evaluate the impact of testosterone treatment on the expansion of visceral, subcutaneous and intramedullary adipose tissue of ovariectomized rats and the visceral and subcutaneous fat expression of peroxisome proliferator-activated receptors (PPARs) gamma METHODS: In tot...
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| Published in: | Revista Brasileira de ginecologia e obstetrícia Vol. 42; no. 1; pp. 43 - 50 |
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| Abstract | The present article aims to evaluate the impact of testosterone treatment on the expansion of visceral, subcutaneous and intramedullary adipose tissue of ovariectomized rats and the visceral and subcutaneous fat expression of peroxisome proliferator-activated receptors (PPARs) gamma
METHODS: In total 48 female Wistar rats were castrated and randomly divided into 6 treatment groups: group E2 was submitted to estradiol 5 μg/day; group T, to testosterone 5 μg/day; group E2 + T, to estradiol 5 μg/day + testosterone 5 μg/day; group TT, to testosterone 30 μg/day; group E2 + TT, to estradiol 5 μg/day + testosterone 30 μg/day; and placebo was administered to group P. After 5 weeks, the rats were euthanized, the inguinal and visceral adipose tissues were harvested, weighted, and had their PPAR gamma expression evaluated by reverse transcription quantitative polymerase chain reaction (RT-qPCR). The right femurs were harvested and histologically prepared to perform the number count of the intramedullary adipocytes.
The expansion of visceral fat tissue was much higher in the TT group when compared with other treated groups (
< 0.001). The TT group also showed a higher expansion of inguinal fat (
< 0.01), and groups E2 + T and E2 + TT presented lower growth compared to the P group (
< 0.01). The number of femur intramedullary adipocytes only showed significant differences between groups TT and E2 + TT (
< 0.05). The expression of PPAR gamma showed no differences among the groups.
The use of testosterone in high doses leads to an important expansion in both visceral and inguinal adipose tissues. Association with estradiol exerts an expansion-repressive effect on the visceral and inguinal adipose tissues. |
|---|---|
| AbstractList | Abstract Objective The present article aims to evaluate the impact of testosterone treatment on the expansion of visceral, subcutaneous and intramedullary adipose tissue of ovariectomized rats and the visceral and subcutaneous fat expression of peroxisome proliferator-activated receptors (PPARs) gamma. Methods In total 48 female Wistar rats were castrated and randomly divided into 6 treatment groups: group E2 was submitted to estradiol 5 μg/day; group T, to testosterone 5 μg/day; group E2+ T, to estradiol 5 μg/day + testosterone 5 μg/day; group TT, to testosterone 30 μg/day; group E2+ TT, to estradiol 5 μg/day+ testosterone 30 μg/day; and placebo was administered to group P. After 5 weeks, the rats were euthanized, the inguinal and visceral adipose tissues were harvested, weighted, and had their PPAR gamma expression evaluated by reverse transcription quantitative polymerase chain reaction (RTqPCR). The right femurs were harvested and histologically prepared to performthe number count of the intramedullary adipocytes. Results The expansion of visceral fat tissue was much higher in the TT group when compared with other treated groups (p < 0.001). The TT group also showed a higher expansion of inguinal fat (p < 0.01), and groups E2 +T and E2+ TT presented lower growth compared to the P group (p < 0.01). The number of femur intramedullary adipocytes only showed significant differences between groups TT and E2 + TT (p < 0.05). The expression of PPAR gamma showed no differences among the groups. Conclusion The use of testosterone in high doses leads to an important expansion in both visceral and inguinal adipose tissues. Association with estradiol exerts an expansion-repressive effect on the visceral and inguinal adipose tissues. Objective The present article aims to evaluate the impact of testosterone treatment on the expansion of visceral, subcutaneous and intramedullary adipose tissue of ovariectomized rats and the visceral and subcutaneous fat expression of peroxisome proliferator-activated receptors (PPARs) gamma . Methods In total 48 female Wistar rats were castrated and randomly divided into 6 treatment groups: group E2 was submitted to estradiol 5 μg/day; group T, to testosterone 5 μg/day; group E2 + T, to estradiol 5 μg/day + testosterone 5 μg/day; group TT, to testosterone 30 μg/day; group E2 + TT, to estradiol 5 μg/day + testosterone 30 μg/day; and placebo was administered to group P. After 5 weeks, the rats were euthanized, the inguinal and visceral adipose tissues were harvested, weighted, and had their PPAR gamma expression evaluated by reverse transcription quantitative polymerase chain reaction (RT-qPCR). The right femurs were harvested and histologically prepared to perform the number count of the intramedullary adipocytes. Results The expansion of visceral fat tissue was much higher in the TT group when compared with other treated groups ( p < 0.001). The TT group also showed a higher expansion of inguinal fat ( p < 0.01), and groups E2 + T and E2 + TT presented lower growth compared to the P group ( p < 0.01). The number of femur intramedullary adipocytes only showed significant differences between groups TT and E2 + TT ( p < 0.05). The expression of PPAR gamma showed no differences among the groups. Conclusion The use of testosterone in high doses leads to an important expansion in both visceral and inguinal adipose tissues. Association with estradiol exerts an expansion-repressive effect on the visceral and inguinal adipose tissues. Objective The present article aims to evaluate the impact of testosterone treatment on the expansion of visceral, subcutaneous and intramedullary adipose tissue of ovariectomized rats and the visceral and subcutaneous fat expression of peroxisome proliferator-activated receptors (PPARs) gamma. Methods In total 48 female Wistar rats were castrated and randomly divided into 6 treatment groups: group E2 was submitted to estradiol 5 μg/day; group T, to testosterone 5 μg/day; group E2 + T, to estradiol 5 μg/day + testosterone 5 μg/day; group TT, to testosterone 30 μg/day; group E2 + TT, to estradiol 5 μg/day + testosterone 30 μg/day; and placebo was administered to group P. After 5 weeks, the rats were euthanized, the inguinal and visceral adipose tissues were harvested, weighted, and had their PPAR gamma expression evaluated by reverse transcription quantitative polymerase chain reaction (RT-qPCR). The right femurs were harvested and histologically prepared to perform the number count of the intramedullary adipocytes. Results The expansion of visceral fat tissue was much higher in the TT group when compared with other treated groups (p < 0.001). The TT group also showed a higher expansion of inguinal fat (p < 0.01), and groups E2 + T and E2 + TT presented lower growth compared to the P group (p < 0.01). The number of femur intramedullary adipocytes only showed significant differences between groups TT and E2 + TT (p < 0.05). The expression of PPAR gamma showed no differences among the groups. Conclusion The use of testosterone in high doses leads to an important expansion in both visceral and inguinal adipose tissues. Association with estradiol exerts an expansion-repressive effect on the visceral and inguinal adipose tissues. OBJECTIVE The present article aims to evaluate the impact of testosterone treatment on the expansion of visceral, subcutaneous and intramedullary adipose tissue of ovariectomized rats and the visceral and subcutaneous fat expression of peroxisome proliferator-activated receptors (PPARs) gamma. METHODS: In total 48 female Wistar rats were castrated and randomly divided into 6 treatment groups: group E2 was submitted to estradiol 5 μg/day; group T, to testosterone 5 μg/day; group E2 + T, to estradiol 5 μg/day + testosterone 5 μg/day; group TT, to testosterone 30 μg/day; group E2 + TT, to estradiol 5 μg/day + testosterone 30 μg/day; and placebo was administered to group P. After 5 weeks, the rats were euthanized, the inguinal and visceral adipose tissues were harvested, weighted, and had their PPAR gamma expression evaluated by reverse transcription quantitative polymerase chain reaction (RT-qPCR). The right femurs were harvested and histologically prepared to perform the number count of the intramedullary adipocytes. RESULTS The expansion of visceral fat tissue was much higher in the TT group when compared with other treated groups (p < 0.001). The TT group also showed a higher expansion of inguinal fat (p < 0.01), and groups E2 + T and E2 + TT presented lower growth compared to the P group (p < 0.01). The number of femur intramedullary adipocytes only showed significant differences between groups TT and E2 + TT (p < 0.05). The expression of PPAR gamma showed no differences among the groups. CONCLUSION The use of testosterone in high doses leads to an important expansion in both visceral and inguinal adipose tissues. Association with estradiol exerts an expansion-repressive effect on the visceral and inguinal adipose tissues. The present article aims to evaluate the impact of testosterone treatment on the expansion of visceral, subcutaneous and intramedullary adipose tissue of ovariectomized rats and the visceral and subcutaneous fat expression of peroxisome proliferator-activated receptors (PPARs) gamma METHODS: In total 48 female Wistar rats were castrated and randomly divided into 6 treatment groups: group E2 was submitted to estradiol 5 μg/day; group T, to testosterone 5 μg/day; group E2 + T, to estradiol 5 μg/day + testosterone 5 μg/day; group TT, to testosterone 30 μg/day; group E2 + TT, to estradiol 5 μg/day + testosterone 30 μg/day; and placebo was administered to group P. After 5 weeks, the rats were euthanized, the inguinal and visceral adipose tissues were harvested, weighted, and had their PPAR gamma expression evaluated by reverse transcription quantitative polymerase chain reaction (RT-qPCR). The right femurs were harvested and histologically prepared to perform the number count of the intramedullary adipocytes. The expansion of visceral fat tissue was much higher in the TT group when compared with other treated groups ( < 0.001). The TT group also showed a higher expansion of inguinal fat ( < 0.01), and groups E2 + T and E2 + TT presented lower growth compared to the P group ( < 0.01). The number of femur intramedullary adipocytes only showed significant differences between groups TT and E2 + TT ( < 0.05). The expression of PPAR gamma showed no differences among the groups. The use of testosterone in high doses leads to an important expansion in both visceral and inguinal adipose tissues. Association with estradiol exerts an expansion-repressive effect on the visceral and inguinal adipose tissues. |
| Author | de Toledo, Olga Maria Szymanski Pompei, Luciano de Melo Veridiano, Juliana Mora Bianco, Bianca da Silva, Lorena Doretto Oliveira, Jussara Celi Conceição Mader, Ana Maria Amaral Antonio Petri, Giuliana Fernandes, César Eduardo Sayeg, Anna Carolina Haddad Steiner, Marcelo Luis |
| AuthorAffiliation | 2 Instituto Médico Legal, São Paulo, SP, Brazil 1 Discipline of Pathology, Faculdade de Medicina do ABC, Santo André, SP, Brazil |
| AuthorAffiliation_xml | – name: 1 Discipline of Pathology, Faculdade de Medicina do ABC, Santo André, SP, Brazil – name: 2 Instituto Médico Legal, São Paulo, SP, Brazil – name: Fundação Oswaldo Cruz – name: Faculdade de Medicina do ABC |
| Author_xml | – sequence: 1 givenname: Lorena Doretto orcidid: 0000-0002-3780-1042 surname: da Silva fullname: da Silva, Lorena Doretto organization: Discipline of Pathology, Faculdade de Medicina do ABC, Santo André, SP, Brazil – sequence: 2 givenname: Juliana Mora orcidid: 0000-0002-5096-7098 surname: Veridiano fullname: Veridiano, Juliana Mora organization: Discipline of Pathology, Faculdade de Medicina do ABC, Santo André, SP, Brazil – sequence: 3 givenname: Jussara Celi Conceição orcidid: 0000-0002-0847-9576 surname: Oliveira fullname: Oliveira, Jussara Celi Conceição organization: Discipline of Pathology, Faculdade de Medicina do ABC, Santo André, SP, Brazil – sequence: 4 givenname: Anna Carolina Haddad orcidid: 0000-0001-5770-6838 surname: Sayeg fullname: Sayeg, Anna Carolina Haddad organization: Discipline of Pathology, Faculdade de Medicina do ABC, Santo André, SP, Brazil – sequence: 5 givenname: Ana Maria Amaral Antonio orcidid: 0000-0002-4973-1467 surname: Mader fullname: Mader, Ana Maria Amaral Antonio organization: Instituto Médico Legal, São Paulo, SP, Brazil – sequence: 6 givenname: Giuliana orcidid: 0000-0002-6078-9184 surname: Petri fullname: Petri, Giuliana organization: Discipline of Pathology, Faculdade de Medicina do ABC, Santo André, SP, Brazil – sequence: 7 givenname: Bianca orcidid: 0000-0001-8669-3562 surname: Bianco fullname: Bianco, Bianca organization: Discipline of Pathology, Faculdade de Medicina do ABC, Santo André, SP, Brazil – sequence: 8 givenname: César Eduardo orcidid: 0000-0002-7796-6386 surname: Fernandes fullname: Fernandes, César Eduardo organization: Discipline of Pathology, Faculdade de Medicina do ABC, Santo André, SP, Brazil – sequence: 9 givenname: Olga Maria Szymanski orcidid: 0000-0002-1563-6621 surname: de Toledo fullname: de Toledo, Olga Maria Szymanski organization: Discipline of Pathology, Faculdade de Medicina do ABC, Santo André, SP, Brazil – sequence: 10 givenname: Luciano de Melo orcidid: 0000-0001-7084-037X surname: Pompei fullname: Pompei, Luciano de Melo organization: Discipline of Pathology, Faculdade de Medicina do ABC, Santo André, SP, Brazil – sequence: 11 givenname: Marcelo Luis orcidid: 0000-0002-2693-9695 surname: Steiner fullname: Steiner, Marcelo Luis organization: Discipline of Pathology, Faculdade de Medicina do ABC, Santo André, SP, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32107765$$D View this record in MEDLINE/PubMed |
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| Keywords | tecido adiposo testosterone adipose tissue testosterona postmenopause pós-menopausa estradiol |
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| Snippet | The present article aims to evaluate the impact of testosterone treatment on the expansion of visceral, subcutaneous and intramedullary adipose tissue of... Objective The present article aims to evaluate the impact of testosterone treatment on the expansion of visceral, subcutaneous and intramedullary adipose... OBJECTIVE The present article aims to evaluate the impact of testosterone treatment on the expansion of visceral, subcutaneous and intramedullary adipose... Objective The present article aims to evaluate the impact of testosterone treatment on the expansion of visceral, subcutaneous and intramedullary adipose... Abstract Objective The present article aims to evaluate the impact of testosterone treatment on the expansion of visceral, subcutaneous and intramedullary... |
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| SubjectTerms | adipose tissue Adipose Tissue - metabolism Animals Disease Models, Animal estradiol Female Hormone Replacement Therapy Menopause OBSTETRICS & GYNECOLOGY Original Ovariectomy postmenopause Rats Rats, Wistar testosterone Testosterone - metabolism Testosterone - pharmacology |
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| Title | The Effect of Testosterone Replacement on Intramedullary, Inguinal and Visceral Fat in Ovariectomized Rats |
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