The role of elastic stresses on leaf venation morphogenesis

• Published in: PLoS computational biology Vol. 4; no. 4; p. e1000055
• Main Authors: Laguna, Maria F, Bohn, Steffen, Jagla, Eduardo A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11-04-2008; Public Library of Science (PLoS)
• Subjects: Computational Biology; Computer Simulation; Elasticity; Evolution; Growth hormones; Hypotheses; Mechanotransduction, Cellular - physiology; Models, Biological; Morphogenesis - physiology; Noise; Physics/Interdisciplinary Physics; Plant Biology/Plant Growth and Development; Plant Leaves - anatomy & histology; Plant Leaves - physiology; Stress, Mechanical; Studies; Morphogenesis; Mechanotransduction, Cellular; Models, Biological; Computer Simulation; Plant Leaves; Elasticity; Stress, Mechanical
• ISSN: 1553-7358; 1553-734X; 1553-7358
• DOI: 10.1371/journal.pcbi.1000055

We explore the possible role of elastic mismatch between epidermis and mesophyll as a driving force for the development of leaf venation. The current prevalent 'canalization' hypothesis for the formation of veins claims that the transport of the hormone auxin out of the leaves triggers cell differentiation to form veins. Although there is evidence that auxin plays a fundamental role in vein formation, the simple canalization mechanism may not be enough to explain some features observed in the vascular system of leaves, in particular, the abundance of vein loops. We present a model based on the existence of mechanical instabilities that leads very naturally to hierarchical patterns with a large number of closed loops. When applied to the structure of high-order veins, the numerical results show the same qualitative features as actual venation patterns and, furthermore, have the same statistical properties. We argue that the agreement between actual and simulated patterns provides strong evidence for the role of mechanical effects on venation development.