Detailed mapping of the Rfv-1 gene that influences spontaneous recovery from Friend retrovirus-induced leukaemia

Using H-2 recombinant and mutant mice, the Rfv-1 gene influencing spontaneous recovery from Friend retrovirus (FV)-induced leukaemia was mapped in the D locus. Two Db alleles were required for full recovery, and a single Dd transgene did not convey increased susceptibility to FV in the presence of h...

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Bibliographic Details
Published in:	European journal of immunogenetics Vol. 19; no. 3; p. 159
Main Authors:	Miyazawa, M, Nishio, J, Wehrly, K, Jay, G, Melvold, R W, Chesebro, B
Format:	Journal Article
Language:	English
Published:	England 01-06-1992
Subjects:	Alleles Animals Chromosome Mapping Friend murine leukemia virus Genotype H-2 Antigens - genetics Haplotypes Leukemia, Experimental - genetics Leukemia, Experimental - immunology Mice Mice, Inbred Strains Mice, Transgenic T-Lymphocytes, Cytotoxic - immunology
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Summary:	Using H-2 recombinant and mutant mice, the Rfv-1 gene influencing spontaneous recovery from Friend retrovirus (FV)-induced leukaemia was mapped in the D locus. Two Db alleles were required for full recovery, and a single Dd transgene did not convey increased susceptibility to FV in the presence of homozygous Db/b genotype. The results suggest that an increase in the expression of Db may lead to more effective stimulation of FV-specific CTL.
ISSN:	0960-7420
DOI:	10.1111/j.1744-313X.1992.tb00054.x