Renaissance of mammalian endogenous RNAi

Renaissance of mammalian endogenous RNAi

RNA interference (RNAi) denotes sequence-specific mRNA degradation induced by long double-stranded RNA (dsRNA). RNAi is an ancient eukaryotic defense mechanism against viruses and mobile elements. In mammals, endogenous RNAi was outstripped during evolution by the current innate and acquired immunit...

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Bibliographic Details
Published in:FEBS letters Vol. 588; no. 15; pp. 2550 - 2556
Main Author: Svoboda, Petr
Format: Journal Article
Language:English
Published: England Elsevier B.V 01-08-2014
Subjects:
Animals
Dicer
Humans
Oocyte
Retrotransposon
RNA Interference
RNA, Small Interfering - genetics
RNA, Small Interfering - metabolism
RNAi
Virus
Virus
Retrotransposon
RNAi
Dicer
Oocyte
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Description
Summary:RNA interference (RNAi) denotes sequence-specific mRNA degradation induced by long double-stranded RNA (dsRNA). RNAi is an ancient eukaryotic defense mechanism against viruses and mobile elements. In mammals, endogenous RNAi was outstripped during evolution by the current innate and acquired immunity. The RNAi apparatus, which remains essentially intact, serves mostly the microRNA pathway, which regulates endogenous gene expression. Remarkably, several recent publications brought the mammalian endogenous RNAi pathway back into the spotlight. Here, I will provide an up-to-date review of the mammalian endogenous RNAi pathway with a focus on its defensive role and overlaps with miRNA and piRNA pathways.
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ObjectType-Review-1
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2014.05.030