Improved cortical histology after cementation with a new MMA-DMA-IBMA bone cement: an animal study

• Published in: Journal of biomedical materials research Vol. 27; no. 5; p. 565
• Main Authors: Nimb, L, Stürup, J, Jensen, J S
• Format: Journal Article
• Language: English
• Published: United States 01-05-1993
• Subjects: Animals; Bone and Bones - anatomy & histology; Bone Cements - chemistry; Bone Remodeling; Dogs; Drug Combinations; Methacrylates - chemistry; Methylmethacrylates - chemistry; Palmitates - chemistry; Temperature; Tibia - anatomy & histology; Waxes - chemistry
• DOI: 10.1002/jbm.820270503
• ISSN: 0021-9304

The histological response of bone to inert bone wax, conventional polymethylmethacrylate (PMMA), and a new formulation of bone cement, methylmethacrylate/n-decylmethacrylate/isobornylmethacrylate (MMA/DMA/IBMA) was investigated in canine tibial diaphysis. The new formulation of cement is characterized by a reduced exothermic temperature at curing and reduced leakage of chemicals to the adjacent bone. In comparison with bone wax, the MMA/DMA/IBMA bone cement did not differ significantly with respect to periosteal apposition and bone remodeling, although a tendency to inhibit the biological response was encountered. The MMA/DMA/IBMA was clearly superior to PMMA bone cement in respect to both bone necrosis and repair, as well as bone remodeling.