Trypanosoma cruzi: Acute and long-term infection in the vertebrate host can modify the response to benznidazole

We analyzed the influence of Trypanosoma cruzi maintenance in different hosts (dog and mouse) on its susceptibility to benznidazole treatment. Five T. cruzi stocks were isolated from dogs inoculated with Be-62 or Be-78 strain (both sensitive to benznidazole) 2–10 years ago, and the benznidazole sens...

Full description

Saved in:

Bibliographic Details
Published in:	Experimental parasitology Vol. 118; no. 3; pp. 315 - 323
Main Authors:	Caldas, Sérgio, Santos, Fabiane M., Lana, Marta de, Diniz, Lívia F., Machado-Coelho, George L.L., Veloso, Vanja M., Bahia, Maria T.
Format:	Journal Article
Language:	English
Published:	San Diego, CA Elsevier Inc 01-03-2008 Elsevier
Subjects:	acute course animal disease models Animals benznidazole Biological and medical sciences Chagas disease Chagas Disease - drug therapy Chagas Disease - parasitology Chemotherapy chronic diseases Cure control cyclophosphamide Cyclophosphamide - pharmacology Dogs Drug resistance Drug Resistance - physiology Female Fundamental and applied biological sciences. Psychology Humans immunosuppression (physiological) Immunosuppressive Agents - pharmacology infection Life cycle. Host-agent relationship. Pathogenesis Mice nifurtimox nitroimidazoles Nitroimidazoles - pharmacology parasitemia Parasitemia - drug therapy Parasitemia - parasitology Protozoa Serial Passage Trypanocidal Agents - pharmacology trypanocides Trypanosoma cruzi Trypanosoma cruzi - drug effects virulence Chemotherapy Cure control Chagas disease Bz Nf Drug resistance Trypanosoma cruzi Kinetoplastida Infection Protozoa Vertebrata Benznidazole Acute Parasite Host Long term
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!