Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats

Appropriate cell number and organ size in a multicellular organism are determined by coordinated cell growth, proliferation, and apoptosis. Disruption of these processes can cause cancer. Recent studies have identified the Large tumor suppressor (Lats)/Warts (Wts) protein kinase as a key component o...

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Bibliographic Details
Published in:	Cell Vol. 120; no. 5; pp. 675 - 685
Main Authors:	Lai, Zhi-Chun, Wei, Xiaomu, Shimizu, Takeshi, Ramos, Edward, Rohrbaugh, Margaret, Nikolaidis, Nikolas, Ho, Li-Lun, Li, Ying
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 11-03-2005
Subjects:	Adaptor Proteins, Signal Transducing Animals Apoptosis - physiology Cell Line Cell Proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Conserved Sequence DNA, Complementary - analysis DNA, Complementary - genetics Drosophila Drosophila Proteins - genetics Drosophila Proteins - isolation & purification Drosophila Proteins - metabolism Evolution, Molecular Gene Expression Regulation, Developmental - genetics Humans Membrane Proteins - genetics Membrane Proteins - metabolism Mice Microscopy, Electron, Scanning Molecular Sequence Data Mutation - genetics Neoplasms - genetics Neoplasms - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Protein Kinases - metabolism Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Transferases (Other Substituted Phosphate Groups) Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - isolation & purification Tumor Suppressor Proteins - metabolism
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