The Drosophila HP1 Homolog Rhino Is Required for Transposon Silencing and piRNA Production by Dual-Strand Clusters
Piwi-interacting RNAs (piRNAs) silence transposons and maintain genome integrity during germline development. In Drosophila, transposon-rich heterochromatic clusters encode piRNAs either on both genomic strands (dual-strand clusters) or predominantly one genomic strand (uni-strand clusters). Primary...
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| Published in: | Cell Vol. 138; no. 6; pp. 1137 - 1149 |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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United States
Elsevier Inc
18-09-2009
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| Abstract | Piwi-interacting RNAs (piRNAs) silence transposons and maintain genome integrity during germline development. In Drosophila, transposon-rich heterochromatic clusters encode piRNAs either on both genomic strands (dual-strand clusters) or predominantly one genomic strand (uni-strand clusters). Primary piRNAs derived from these clusters are proposed to drive a ping-pong amplification cycle catalyzed by proteins that localize to the perinuclear nuage. We show that the HP1 homolog Rhino is required for nuage organization, transposon silencing, and ping-pong amplification of piRNAs. rhi mutations virtually eliminate piRNAs from the dual-strand clusters and block production of putative precursor RNAs from both strands of the major 42AB dual-strand cluster, but not of transcripts or piRNAs from the uni-strand clusters. Furthermore, Rhino protein associates with the 42AB dual-strand cluster,but does not bind to uni-strand cluster 2 or flamenco. Rhino thus appears to promote transcription of dual-strand clusters, leading to production of piRNAs that drive the ping-pong amplification cycle. |
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| AbstractList | Piwi-interacting RNAs (piRNAs) silence transposons and maintain genome integrity during germline development. In Drosophila, transposon-rich heterochromatic clusters encode piRNAs either on both genomic strands (dual-strand clusters) or predominantly one genomic strand (uni-strand clusters). Primary piRNAs derived from these clusters are proposed to drive a ping-pong amplification cycle catalyzed by proteins that localize to the perinuclear nuage. We show that the HP1 homolog Rhino is required for nuage organization, transposon silencing, and ping-pong amplification of piRNAs. rhi mutations virtually eliminate piRNAs from the dual-strand clusters and block production of putative precursor RNAs from both strands of the major 42AB dual-strand cluster, but not of transcripts or piRNAs from the uni-strand clusters. Furthermore, Rhino protein associates with the 42AB dual-strand cluster,but does not bind to uni-strand cluster 2 or flamenco. Rhino thus appears to promote transcription of dual-strand clusters, leading to production of piRNAs that drive the ping-pong amplification cycle. |
| Author | Klattenhoff, Carla Xi, Hualin Seitz, Herve Lee, Soohyun Zhang, Fan Weng, Zhiping Theurkauf, William E. Khurana, Jaspreet S. Xu, Jia Schultz, Nadine Koppetsch, Birgit S. Nowosielska, Anetta Li, Chengjian Zamore, Phillip D. |
| Author_xml | – sequence: 1 givenname: Carla surname: Klattenhoff fullname: Klattenhoff, Carla organization: Program in Molecular Medicine and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester MA, 01605, USA – sequence: 2 givenname: Hualin surname: Xi fullname: Xi, Hualin organization: Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester MA, 01605, USA – sequence: 3 givenname: Chengjian surname: Li fullname: Li, Chengjian organization: Department of Biochemistry and Molecular Pharmacology and Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester MA, 01605, USA – sequence: 4 givenname: Soohyun surname: Lee fullname: Lee, Soohyun organization: Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester MA, 01605, USA – sequence: 5 givenname: Jia surname: Xu fullname: Xu, Jia organization: Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester MA, 01605, USA – sequence: 6 givenname: Jaspreet S. surname: Khurana fullname: Khurana, Jaspreet S. organization: Program in Molecular Medicine and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester MA, 01605, USA – sequence: 7 givenname: Fan surname: Zhang fullname: Zhang, Fan organization: Program in Molecular Medicine and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester MA, 01605, USA – sequence: 8 givenname: Nadine surname: Schultz fullname: Schultz, Nadine organization: Program in Molecular Medicine and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester MA, 01605, USA – sequence: 9 givenname: Birgit S. surname: Koppetsch fullname: Koppetsch, Birgit S. organization: Program in Molecular Medicine and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester MA, 01605, USA – sequence: 10 givenname: Anetta surname: Nowosielska fullname: Nowosielska, Anetta organization: Program in Molecular Medicine and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester MA, 01605, USA – sequence: 11 givenname: Herve surname: Seitz fullname: Seitz, Herve organization: Department of Biochemistry and Molecular Pharmacology and Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester MA, 01605, USA – sequence: 12 givenname: Phillip D. surname: Zamore fullname: Zamore, Phillip D. email: phillip.zamore@umassmed.edu organization: Department of Biochemistry and Molecular Pharmacology and Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester MA, 01605, USA – sequence: 13 givenname: Zhiping surname: Weng fullname: Weng, Zhiping email: zhiping.weng@umassmed.edu organization: Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester MA, 01605, USA – sequence: 14 givenname: William E. surname: Theurkauf fullname: Theurkauf, William E. email: william.theurkauf@umassmed.edu organization: Program in Molecular Medicine and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester MA, 01605, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19732946$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1093/genetics/139.2.697 10.1002/j.1460-2075.1994.tb06760.x 10.1534/genetics.106.068106 10.1534/genetics.166.3.1313 10.1093/genetics/124.2.303 10.1016/S1097-2765(02)00440-9 10.1073/pnas.92.13.6067 10.1016/S0960-9822(01)00299-8 10.1093/genetics/104.1.63 10.1093/genetics/159.3.1117 10.1016/S0092-8674(04)00250-8 10.1126/science.1092653 10.1016/S1534-5807(03)00228-4 10.1016/S0065-2660(07)00001-6 10.1016/j.cell.2007.01.043 10.1016/j.cub.2003.11.006 10.1016/S0959-437X(02)00282-4 10.1016/S0092-8674(03)00202-2 10.1016/j.cell.2006.04.025 10.1016/j.devcel.2007.03.001 10.1016/j.cub.2007.02.027 10.1126/science.1165171 10.1016/S0092-8674(01)00419-6 10.1126/science.1140494 10.1126/science.1129333 10.1016/j.devcel.2006.12.001 10.1016/j.cub.2007.12.049 10.1016/j.cell.2007.03.028 10.1371/journal.pgen.0010067 10.1073/pnas.0805943105 10.1242/dev.120.5.1201 10.1128/MCB.24.3.1219-1231.2004 10.1126/science.1139815 10.1371/journal.pone.0001526 10.1016/j.cell.2007.03.026 10.1101/gad.12.18.2932 10.1101/gad.1564307 10.1093/genetics/107.4.611 10.1093/nar/30.1.207 10.1016/j.cell.2009.04.027 10.1101/gad.1454806 10.1038/35087045 10.1038/nrg2504 10.1016/0092-8674(95)90478-6 10.1093/genetics/138.4.1181 10.1093/molbev/msl176 10.1242/jcs.00614 10.1016/j.devcel.2008.05.015 10.1126/science.1157396 10.1016/j.devcel.2007.03.022 10.1016/S0960-9822(01)00112-9 10.1002/jcp.20700 10.1073/pnas.0701920104 10.1016/j.febslet.2005.08.083 10.1371/journal.pgen.0010009 10.1126/science.1137543 10.1007/BF00291049 10.1016/S0091-679X(08)60928-0 |
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| Copyright | 2009 Elsevier Inc. |
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| References | Pelisson, Song, Prud'homme, Smith, Bucheton, Corces (bib43) 1994; 13 Saito, Nishida, Mori, Kawamura, Miyoshi, Nagami, Siomi, Siomi (bib47) 2006; 20 Lim, Kai (bib31) 2007; 104 Chambeyron, Popkova, Payen-Groschene, Brun, Laouini, Pelisson, Bucheton (bib13) 2008; 105 Houwing, Kamminga, Berezikov, Cronembold, Girard, van den Elst, Filippov, Blaser, Raz, Moens (bib26) 2007; 129 Li, Vagin, Lee, Xu, Ma, Xi, Seitz, Horwich, Syrzycka, Honda (bib29) 2009; 137 Livak (bib34) 1990; 124 Brennecke, Aravin, Stark, Dus, Kellis, Sachidanandam, Hannon (bib6) 2007; 128 Elgin, Grewal (bib18) 2003; 13 Gunawardane, Saito, Nishida, Miyoshi, Kawamura, Nagami, Siomi, Siomi (bib23) 2007; 315 Klattenhoff, Bratu, McGinnis-Schultz, Koppetsch, Cook, Theurkauf (bib28) 2007; 12 Pal-Bhadra, Leibovitch, Gandhi, Rao, Bhadra, Birchler, Elgin (bib40) 2004; 303 Hawley, Tartof (bib25) 1983; 104 Liang, Diehl-Jones, Lasko (bib30) 1994; 120 Bozzetti, Massari, Finelli, Meggio, Pinna, Boldyreff, Issinger, Palumbo, Ciriaco, Bonaccorsi (bib5) 1995; 92 Sarkaria, Busby, Tibbetts, Roos, Taya, Karnitz, Abraham (bib48) 1999; 59 Buhler, Verdel, Moazed (bib10) 2006; 125 Wang, Redpath, Fan, Stanbridge (bib59) 2006; 208 Pane, Wehr, Schupbach (bib42) 2007; 12 Prud'homme, Gans, Masson, Terzian, Bucheton (bib45) 1995; 139 Seitz, Ghildiyal, Zamore (bib50) 2008; 18 Carmell, Girard, van de Kant, Bourc'his, Bestor, de Rooij, Hannon (bib11) 2007; 12 Lin (bib32) 2007; 316 Girton, Johansen (bib21) 2008; 61 Cook, Koppetsch, Wu, Theurkauf (bib15) 2004; 116 O'Donnell, Boeke (bib38) 2007; 129 Vermaak, Henikoff, Malik (bib57) 2005; 1 Aravin, Naumova, Tulin, Vagin, Rozovsky, Gvozdev (bib1) 2001; 11 Hari, Santerre, Sekelsky, McKim, Boyd, Hawley (bib24) 1995; 82 Redon, Pilch, Rogakou, Sedelnikova, Newrock, Bonner (bib46) 2002; 12 Jang, Sherizen, Bhagat, Manheim, McKim (bib27) 2003; 116 Belmont, Braunfeld, Sedat, Agard (bib3) 1989; 98 Cha, Koppetsch, Theurkauf (bib12) 2001; 106 Pal-Bhadra, Bhadra, Birchler (bib39) 2002; 9 Vagin, Sigova, Li, Seitz, Gvozdev, Zamore (bib55) 2006; 313 Modesti, Kanaar (bib37) 2001; 11 Gong, McKim, Hawley (bib22) 2005; 1 Chen, Pane, Schupbach (bib14) 2007; 17 Mevel-Ninio, Pelisson, Kinder, Campos, Bucheton (bib36) 2007; 175 Takada, Kelkar, Theurkauf (bib53) 2003; 113 Brennecke, Malone, Aravin, Sachidanandam, Stark, Hannon (bib7) 2008; 322 Aravin, Lagos-Quintana, Yalcin, Zavolan, Marks, Snyder, Gaasterland, Meyer, Tuschl (bib2) 2003; 5 Soper, van der Heijden, Hardiman, Goodheart, Martin, de Boer, Bortvin (bib52) 2008; 15 Blower, Karpen (bib4) 2001; 3 Palumbo, Bonaccorsi, Robbins, Pimpinelli (bib41) 1994; 138 Verdel, Moazed (bib56) 2005; 579 Brower-Toland, Findley, Jiang, Liu, Yin, Dus, Zhou, Elgin, Lin (bib9) 2007; 21 Edgar, Domrachev, Lash (bib17) 2002; 30 Theurkauf (bib54) 1994; 44 Ghildiyal, Zamore (bib19) 2009; 10 Ghildiyal, Seitz, Horwich, Li, Du, Lee, Xu, Kittler, Zapp, Weng, Zamore (bib20) 2008; 320 Pelisson, Payen-Groschene, Terzian, Bucheton (bib44) 2007; 24 Brodsky, Weinert, Tsang, Rong, McGinnis, Golic, Rio, Rubin (bib8) 2004; 24 Volpe, Horowitz, Grafer, Jackson, Berg (bib58) 2001; 159 Desset, Buchon, Meignin, Coiffet, Vaury (bib16) 2008; 3 Livak (bib33) 1984; 107 Sarot, Payen-Groschene, Bucheton, Pelisson (bib49) 2004; 166 McKim, Hayashi-Hagihara (bib35) 1998; 12 Smith, Shu, Mungall, Karpen (bib51) 2007; 316 19766558 - Cell. 2009 Sep 18;138(6):1058-60 Pelisson (10.1016/j.cell.2009.07.014_bib44) 2007; 24 Volpe (10.1016/j.cell.2009.07.014_bib58) 2001; 159 Brennecke (10.1016/j.cell.2009.07.014_bib7) 2008; 322 Cha (10.1016/j.cell.2009.07.014_bib12) 2001; 106 O'Donnell (10.1016/j.cell.2009.07.014_bib38) 2007; 129 Takada (10.1016/j.cell.2009.07.014_bib53) 2003; 113 Seitz (10.1016/j.cell.2009.07.014_bib50) 2008; 18 Girton (10.1016/j.cell.2009.07.014_bib21) 2008; 61 McKim (10.1016/j.cell.2009.07.014_bib35) 1998; 12 Redon (10.1016/j.cell.2009.07.014_bib46) 2002; 12 Pelisson (10.1016/j.cell.2009.07.014_bib43) 1994; 13 Livak (10.1016/j.cell.2009.07.014_bib33) 1984; 107 Sarot (10.1016/j.cell.2009.07.014_bib49) 2004; 166 Desset (10.1016/j.cell.2009.07.014_bib16) 2008; 3 Prud'homme (10.1016/j.cell.2009.07.014_bib45) 1995; 139 Belmont (10.1016/j.cell.2009.07.014_bib3) 1989; 98 Palumbo (10.1016/j.cell.2009.07.014_bib41) 1994; 138 Chambeyron (10.1016/j.cell.2009.07.014_bib13) 2008; 105 Saito (10.1016/j.cell.2009.07.014_bib47) 2006; 20 Vagin (10.1016/j.cell.2009.07.014_bib55) 2006; 313 Verdel (10.1016/j.cell.2009.07.014_bib56) 2005; 579 Aravin (10.1016/j.cell.2009.07.014_bib2) 2003; 5 Liang (10.1016/j.cell.2009.07.014_bib30) 1994; 120 Lim (10.1016/j.cell.2009.07.014_bib31) 2007; 104 Pal-Bhadra (10.1016/j.cell.2009.07.014_bib39) 2002; 9 Gong (10.1016/j.cell.2009.07.014_bib22) 2005; 1 Ghildiyal (10.1016/j.cell.2009.07.014_bib20) 2008; 320 Carmell (10.1016/j.cell.2009.07.014_bib11) 2007; 12 Smith (10.1016/j.cell.2009.07.014_bib51) 2007; 316 Blower (10.1016/j.cell.2009.07.014_bib4) 2001; 3 Brower-Toland (10.1016/j.cell.2009.07.014_bib9) 2007; 21 Chen (10.1016/j.cell.2009.07.014_bib14) 2007; 17 Klattenhoff (10.1016/j.cell.2009.07.014_bib28) 2007; 12 Mevel-Ninio (10.1016/j.cell.2009.07.014_bib36) 2007; 175 Theurkauf (10.1016/j.cell.2009.07.014_bib54) 1994; 44 Pal-Bhadra (10.1016/j.cell.2009.07.014_bib40) 2004; 303 Cook (10.1016/j.cell.2009.07.014_bib15) 2004; 116 Edgar (10.1016/j.cell.2009.07.014_bib17) 2002; 30 Bozzetti (10.1016/j.cell.2009.07.014_bib5) 1995; 92 Vermaak (10.1016/j.cell.2009.07.014_bib57) 2005; 1 Hawley (10.1016/j.cell.2009.07.014_bib25) 1983; 104 Brodsky (10.1016/j.cell.2009.07.014_bib8) 2004; 24 Li (10.1016/j.cell.2009.07.014_bib29) 2009; 137 Gunawardane (10.1016/j.cell.2009.07.014_bib23) 2007; 315 Jang (10.1016/j.cell.2009.07.014_bib27) 2003; 116 Elgin (10.1016/j.cell.2009.07.014_bib18) 2003; 13 Ghildiyal (10.1016/j.cell.2009.07.014_bib19) 2009; 10 Pane (10.1016/j.cell.2009.07.014_bib42) 2007; 12 Houwing (10.1016/j.cell.2009.07.014_bib26) 2007; 129 Buhler (10.1016/j.cell.2009.07.014_bib10) 2006; 125 Brennecke (10.1016/j.cell.2009.07.014_bib6) 2007; 128 Hari (10.1016/j.cell.2009.07.014_bib24) 1995; 82 Lin (10.1016/j.cell.2009.07.014_bib32) 2007; 316 Wang (10.1016/j.cell.2009.07.014_bib59) 2006; 208 Livak (10.1016/j.cell.2009.07.014_bib34) 1990; 124 Soper (10.1016/j.cell.2009.07.014_bib52) 2008; 15 Aravin (10.1016/j.cell.2009.07.014_bib1) 2001; 11 Modesti (10.1016/j.cell.2009.07.014_bib37) 2001; 11 Sarkaria (10.1016/j.cell.2009.07.014_bib48) 1999; 59 |
| References_xml | – volume: 137 start-page: 509 year: 2009 end-page: 521 ident: bib29 article-title: Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies publication-title: Cell contributor: fullname: Honda – volume: 3 start-page: e1526 year: 2008 ident: bib16 article-title: In Drosophila melanogaster the COM locus directs the somatic silencing of two retrotransposons through both Piwi-dependent and -independent pathways publication-title: PLoS ONE contributor: fullname: Vaury – volume: 316 start-page: 397 year: 2007 ident: bib32 article-title: piRNAs in the germ line publication-title: Science contributor: fullname: Lin – volume: 322 start-page: 1387 year: 2008 end-page: 1392 ident: bib7 article-title: An epigenetic role for maternally inherited piRNAs in transposon silencing publication-title: Science contributor: fullname: Hannon – volume: 82 start-page: 815 year: 1995 end-page: 821 ident: bib24 article-title: The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene publication-title: Cell contributor: fullname: Hawley – volume: 104 start-page: 63 year: 1983 end-page: 80 ident: bib25 article-title: The effect of mei-41 on rDNA redundancy in Drosophila melanogaster publication-title: Genetics contributor: fullname: Tartof – volume: 1 start-page: 96 year: 2005 end-page: 108 ident: bib57 article-title: Positive selection drives the evolution of rhino, a member of the heterochromatin protein 1 family in Drosophila publication-title: PLoS Genet. contributor: fullname: Malik – volume: 18 start-page: 147 year: 2008 end-page: 151 ident: bib50 article-title: Argonaute loading improves the 5′ precision of both MicroRNAs and their miRNA strands in flies publication-title: Curr. Biol. contributor: fullname: Zamore – volume: 106 start-page: 35 year: 2001 end-page: 46 ident: bib12 article-title: analysis of publication-title: Cell contributor: fullname: Theurkauf – volume: 12 start-page: 45 year: 2007 end-page: 55 ident: bib28 article-title: Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response publication-title: Dev. Cell contributor: fullname: Theurkauf – volume: 17 start-page: 637 year: 2007 end-page: 642 ident: bib14 article-title: Cutoff and aubergine mutations result in retrotransposon upregulation and checkpoint activation in Drosophila publication-title: Curr. Biol. contributor: fullname: Schupbach – volume: 12 start-page: 2932 year: 1998 end-page: 2942 ident: bib35 article-title: mei-W68 in Drosophila melanogaster encodes a Spo11 homolog: evidence that the mechanism for initiating meiotic recombination is conserved publication-title: Genes Dev. contributor: fullname: Hayashi-Hagihara – volume: 320 start-page: 1077 year: 2008 end-page: 1081 ident: bib20 article-title: Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells publication-title: Science contributor: fullname: Zamore – volume: 166 start-page: 1313 year: 2004 end-page: 1321 ident: bib49 article-title: Evidence for a piwi-dependent RNA silencing of the gypsy endogenous retrovirus by the Drosophila melanogaster flamenco gene publication-title: Genetics contributor: fullname: Pelisson – volume: 13 start-page: 4401 year: 1994 end-page: 4411 ident: bib43 article-title: Gypsy transposition correlates with the production of a retroviral envelope-like protein under the tissue-specific control of the Drosophila flamenco gene publication-title: EMBO J. contributor: fullname: Corces – volume: 13 start-page: R895 year: 2003 end-page: R898 ident: bib18 article-title: Heterochromatin: silence is golden publication-title: Curr. Biol. contributor: fullname: Grewal – volume: 59 start-page: 4375 year: 1999 end-page: 4382 ident: bib48 article-title: Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine publication-title: Cancer Res. contributor: fullname: Abraham – volume: 315 start-page: 1587 year: 2007 end-page: 1590 ident: bib23 article-title: A slicer-mediated mechanism for repeat-associated siRNA 5′ end formation in Drosophila publication-title: Science contributor: fullname: Siomi – volume: 11 start-page: R229 year: 2001 end-page: R232 ident: bib37 article-title: DNA repair: spot(light)s on chromatin publication-title: Curr. Biol. contributor: fullname: Kanaar – volume: 139 start-page: 697 year: 1995 end-page: 711 ident: bib45 article-title: Flamenco, a gene controlling the gypsy retrovirus of Drosophila melanogaster publication-title: Genetics contributor: fullname: Bucheton – volume: 124 start-page: 303 year: 1990 end-page: 316 ident: bib34 article-title: Detailed structure of the Drosophila melanogaster stellate genes and their transcripts publication-title: Genetics contributor: fullname: Livak – volume: 21 start-page: 2300 year: 2007 end-page: 2311 ident: bib9 article-title: Drosophila PIWI associates with chromatin and interacts directly with HP1a publication-title: Genes Dev. contributor: fullname: Lin – volume: 105 start-page: 14964 year: 2008 end-page: 14969 ident: bib13 article-title: piRNA-mediated nuclear accumulation of retrotransposon transcripts in the Drosophila female germline publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Bucheton – volume: 107 start-page: 611 year: 1984 end-page: 634 ident: bib33 article-title: Organization and mapping of a sequence on the Drosophila melanogaster X and Y chromosomes that is transcribed during spermatogenesis publication-title: Genetics contributor: fullname: Livak – volume: 303 start-page: 669 year: 2004 end-page: 672 ident: bib40 article-title: Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery publication-title: Science contributor: fullname: Elgin – volume: 116 start-page: 817 year: 2004 end-page: 829 ident: bib15 article-title: The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification publication-title: Cell contributor: fullname: Theurkauf – volume: 15 start-page: 285 year: 2008 end-page: 297 ident: bib52 article-title: Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis publication-title: Dev. Cell contributor: fullname: Bortvin – volume: 313 start-page: 320 year: 2006 end-page: 324 ident: bib55 article-title: A distinct small RNA pathway silences selfish genetic elements in the germline publication-title: Science contributor: fullname: Zamore – volume: 208 start-page: 613 year: 2006 end-page: 619 ident: bib59 article-title: ATR dependent activation of Chk2 publication-title: J. Cell. Physiol. contributor: fullname: Stanbridge – volume: 129 start-page: 69 year: 2007 end-page: 82 ident: bib26 article-title: A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish publication-title: Cell contributor: fullname: Moens – volume: 44 start-page: 489 year: 1994 end-page: 505 ident: bib54 article-title: Immunofluorescence analysis of the cytoskeleton during oogenesis and early embryogenesis publication-title: Methods Cell Biol. contributor: fullname: Theurkauf – volume: 12 start-page: 162 year: 2002 end-page: 169 ident: bib46 article-title: Histone H2A variants H2AX and H2AZ publication-title: Curr. Opin. Genet. Dev. contributor: fullname: Bonner – volume: 9 start-page: 315 year: 2002 end-page: 327 ident: bib39 article-title: RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila publication-title: Mol. Cell contributor: fullname: Birchler – volume: 12 start-page: 851 year: 2007 end-page: 862 ident: bib42 article-title: zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline publication-title: Dev. Cell contributor: fullname: Schupbach – volume: 3 start-page: 730 year: 2001 end-page: 739 ident: bib4 article-title: The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions publication-title: Nat. Cell Biol. contributor: fullname: Karpen – volume: 138 start-page: 1181 year: 1994 end-page: 1197 ident: bib41 article-title: Genetic analysis of Stellate elements of Drosophila melanogaster publication-title: Genetics contributor: fullname: Pimpinelli – volume: 125 start-page: 873 year: 2006 end-page: 886 ident: bib10 article-title: Tethering RITS to a nascent transcript initiates RNAi- and heterochromatin-dependent gene silencing publication-title: Cell contributor: fullname: Moazed – volume: 12 start-page: 503 year: 2007 end-page: 514 ident: bib11 article-title: MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline publication-title: Dev. Cell contributor: fullname: Hannon – volume: 104 start-page: 6714 year: 2007 end-page: 6719 ident: bib31 article-title: Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Kai – volume: 24 start-page: 498 year: 2007 end-page: 504 ident: bib44 article-title: Restrictive flamenco alleles are maintained in Drosophila melanogaster population cages, despite the absence of their endogenous gypsy retroviral targets publication-title: Mol. Biol. Evol. contributor: fullname: Bucheton – volume: 24 start-page: 1219 year: 2004 end-page: 1231 ident: bib8 article-title: Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage publication-title: Mol. Cell. Biol. contributor: fullname: Rubin – volume: 113 start-page: 87 year: 2003 end-page: 99 ident: bib53 article-title: Drosophila checkpoint kinase 2 couples centrosome function and spindle assembly to genomic integrity publication-title: Cell contributor: fullname: Theurkauf – volume: 159 start-page: 1117 year: 2001 end-page: 1134 ident: bib58 article-title: Drosophila rhino encodes a female-specific chromo-domain protein that affects chromosome structure and egg polarity publication-title: Genetics contributor: fullname: Berg – volume: 30 start-page: 207 year: 2002 end-page: 210 ident: bib17 article-title: Gene Expression Omnibus: NCBI gene expression and hybridization array data repository publication-title: Nucleic Acids Res. contributor: fullname: Lash – volume: 116 start-page: 3069 year: 2003 end-page: 3077 ident: bib27 article-title: Relationship of DNA double-strand breaks to synapsis in Drosophila publication-title: J. Cell Sci. contributor: fullname: McKim – volume: 61 start-page: 1 year: 2008 end-page: 43 ident: bib21 article-title: Chromatin structure and the regulation of gene expression: the lessons of PEV in Drosophila publication-title: Adv. Genet. contributor: fullname: Johansen – volume: 120 start-page: 1201 year: 1994 end-page: 1211 ident: bib30 article-title: Localization of vasa protein to the Drosophila pole plasm is independent of its RNA-binding and helicase activities publication-title: Development contributor: fullname: Lasko – volume: 92 start-page: 6067 year: 1995 end-page: 6071 ident: bib5 article-title: The Ste locus, a component of the parasitic cry-Ste system of Drosophila melanogaster, encodes a protein that forms crystals in primary spermatocytes and mimics properties of the beta subunit of casein kinase 2 publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Bonaccorsi – volume: 129 start-page: 37 year: 2007 end-page: 44 ident: bib38 article-title: Mighty Piwis defend the germline against genome intruders publication-title: Cell contributor: fullname: Boeke – volume: 98 start-page: 129 year: 1989 end-page: 143 ident: bib3 article-title: Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitro publication-title: Chromosoma contributor: fullname: Agard – volume: 20 start-page: 2214 year: 2006 end-page: 2222 ident: bib47 article-title: Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome publication-title: Genes Dev. contributor: fullname: Siomi – volume: 316 start-page: 1586 year: 2007 end-page: 1591 ident: bib51 article-title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin publication-title: Science contributor: fullname: Karpen – volume: 5 start-page: 337 year: 2003 end-page: 350 ident: bib2 article-title: The small RNA profile during Drosophila melanogaster development publication-title: Dev. Cell contributor: fullname: Tuschl – volume: 128 start-page: 1089 year: 2007 end-page: 1103 ident: bib6 article-title: Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila publication-title: Cell contributor: fullname: Hannon – volume: 10 start-page: 94 year: 2009 end-page: 108 ident: bib19 article-title: Small silencing RNAs: an expanding universe publication-title: Nat. Rev. Genet. contributor: fullname: Zamore – volume: 579 start-page: 5872 year: 2005 end-page: 5878 ident: bib56 article-title: RNAi-directed assembly of heterochromatin in fission yeast publication-title: FEBS Lett. contributor: fullname: Moazed – volume: 175 start-page: 1615 year: 2007 end-page: 1624 ident: bib36 article-title: The flamenco locus controls the gypsy and ZAM retroviruses and is required for Drosophila oogenesis publication-title: Genetics contributor: fullname: Bucheton – volume: 11 start-page: 1017 year: 2001 end-page: 1027 ident: bib1 article-title: Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline publication-title: Curr. Biol. contributor: fullname: Gvozdev – volume: 1 start-page: e67 year: 2005 ident: bib22 article-title: All paired up with no place to go: pairing, synapsis, and DSB formation in a balancer heterozygote publication-title: PLoS Genet. contributor: fullname: Hawley – volume: 139 start-page: 697 year: 1995 ident: 10.1016/j.cell.2009.07.014_bib45 article-title: Flamenco, a gene controlling the gypsy retrovirus of Drosophila melanogaster publication-title: Genetics doi: 10.1093/genetics/139.2.697 contributor: fullname: Prud'homme – volume: 13 start-page: 4401 year: 1994 ident: 10.1016/j.cell.2009.07.014_bib43 article-title: Gypsy transposition correlates with the production of a retroviral envelope-like protein under the tissue-specific control of the Drosophila flamenco gene publication-title: EMBO J. doi: 10.1002/j.1460-2075.1994.tb06760.x contributor: fullname: Pelisson – volume: 175 start-page: 1615 year: 2007 ident: 10.1016/j.cell.2009.07.014_bib36 article-title: The flamenco locus controls the gypsy and ZAM retroviruses and is required for Drosophila oogenesis publication-title: Genetics doi: 10.1534/genetics.106.068106 contributor: fullname: Mevel-Ninio – volume: 166 start-page: 1313 year: 2004 ident: 10.1016/j.cell.2009.07.014_bib49 article-title: Evidence for a piwi-dependent RNA silencing of the gypsy endogenous retrovirus by the Drosophila melanogaster flamenco gene publication-title: Genetics doi: 10.1534/genetics.166.3.1313 contributor: fullname: Sarot – volume: 124 start-page: 303 year: 1990 ident: 10.1016/j.cell.2009.07.014_bib34 article-title: Detailed structure of the Drosophila melanogaster stellate genes and their transcripts publication-title: Genetics doi: 10.1093/genetics/124.2.303 contributor: fullname: Livak – volume: 9 start-page: 315 year: 2002 ident: 10.1016/j.cell.2009.07.014_bib39 article-title: RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila publication-title: Mol. Cell doi: 10.1016/S1097-2765(02)00440-9 contributor: fullname: Pal-Bhadra – volume: 92 start-page: 6067 year: 1995 ident: 10.1016/j.cell.2009.07.014_bib5 article-title: The Ste locus, a component of the parasitic cry-Ste system of Drosophila melanogaster, encodes a protein that forms crystals in primary spermatocytes and mimics properties of the beta subunit of casein kinase 2 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.92.13.6067 contributor: fullname: Bozzetti – volume: 11 start-page: 1017 year: 2001 ident: 10.1016/j.cell.2009.07.014_bib1 article-title: Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline publication-title: Curr. Biol. doi: 10.1016/S0960-9822(01)00299-8 contributor: fullname: Aravin – volume: 104 start-page: 63 year: 1983 ident: 10.1016/j.cell.2009.07.014_bib25 article-title: The effect of mei-41 on rDNA redundancy in Drosophila melanogaster publication-title: Genetics doi: 10.1093/genetics/104.1.63 contributor: fullname: Hawley – volume: 159 start-page: 1117 year: 2001 ident: 10.1016/j.cell.2009.07.014_bib58 article-title: Drosophila rhino encodes a female-specific chromo-domain protein that affects chromosome structure and egg polarity publication-title: Genetics doi: 10.1093/genetics/159.3.1117 contributor: fullname: Volpe – volume: 116 start-page: 817 year: 2004 ident: 10.1016/j.cell.2009.07.014_bib15 article-title: The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification publication-title: Cell doi: 10.1016/S0092-8674(04)00250-8 contributor: fullname: Cook – volume: 303 start-page: 669 year: 2004 ident: 10.1016/j.cell.2009.07.014_bib40 article-title: Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery publication-title: Science doi: 10.1126/science.1092653 contributor: fullname: Pal-Bhadra – volume: 5 start-page: 337 year: 2003 ident: 10.1016/j.cell.2009.07.014_bib2 article-title: The small RNA profile during Drosophila melanogaster development publication-title: Dev. Cell doi: 10.1016/S1534-5807(03)00228-4 contributor: fullname: Aravin – volume: 61 start-page: 1 year: 2008 ident: 10.1016/j.cell.2009.07.014_bib21 article-title: Chromatin structure and the regulation of gene expression: the lessons of PEV in Drosophila publication-title: Adv. Genet. doi: 10.1016/S0065-2660(07)00001-6 contributor: fullname: Girton – volume: 128 start-page: 1089 year: 2007 ident: 10.1016/j.cell.2009.07.014_bib6 article-title: Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila publication-title: Cell doi: 10.1016/j.cell.2007.01.043 contributor: fullname: Brennecke – volume: 13 start-page: R895 year: 2003 ident: 10.1016/j.cell.2009.07.014_bib18 article-title: Heterochromatin: silence is golden publication-title: Curr. Biol. doi: 10.1016/j.cub.2003.11.006 contributor: fullname: Elgin – volume: 12 start-page: 162 year: 2002 ident: 10.1016/j.cell.2009.07.014_bib46 article-title: Histone H2A variants H2AX and H2AZ publication-title: Curr. Opin. Genet. Dev. doi: 10.1016/S0959-437X(02)00282-4 contributor: fullname: Redon – volume: 113 start-page: 87 year: 2003 ident: 10.1016/j.cell.2009.07.014_bib53 article-title: Drosophila checkpoint kinase 2 couples centrosome function and spindle assembly to genomic integrity publication-title: Cell doi: 10.1016/S0092-8674(03)00202-2 contributor: fullname: Takada – volume: 125 start-page: 873 year: 2006 ident: 10.1016/j.cell.2009.07.014_bib10 article-title: Tethering RITS to a nascent transcript initiates RNAi- and heterochromatin-dependent gene silencing publication-title: Cell doi: 10.1016/j.cell.2006.04.025 contributor: fullname: Buhler – volume: 12 start-page: 503 year: 2007 ident: 10.1016/j.cell.2009.07.014_bib11 article-title: MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline publication-title: Dev. Cell doi: 10.1016/j.devcel.2007.03.001 contributor: fullname: Carmell – volume: 17 start-page: 637 year: 2007 ident: 10.1016/j.cell.2009.07.014_bib14 article-title: Cutoff and aubergine mutations result in retrotransposon upregulation and checkpoint activation in Drosophila publication-title: Curr. Biol. doi: 10.1016/j.cub.2007.02.027 contributor: fullname: Chen – volume: 322 start-page: 1387 year: 2008 ident: 10.1016/j.cell.2009.07.014_bib7 article-title: An epigenetic role for maternally inherited piRNAs in transposon silencing publication-title: Science doi: 10.1126/science.1165171 contributor: fullname: Brennecke – volume: 106 start-page: 35 year: 2001 ident: 10.1016/j.cell.2009.07.014_bib12 article-title: In vivo analysis of bicoid mRNA localization reveals a novel microtubule-dependent anterior axis specification pathway publication-title: Cell doi: 10.1016/S0092-8674(01)00419-6 contributor: fullname: Cha – volume: 315 start-page: 1587 year: 2007 ident: 10.1016/j.cell.2009.07.014_bib23 article-title: A slicer-mediated mechanism for repeat-associated siRNA 5′ end formation in Drosophila publication-title: Science doi: 10.1126/science.1140494 contributor: fullname: Gunawardane – volume: 313 start-page: 320 year: 2006 ident: 10.1016/j.cell.2009.07.014_bib55 article-title: A distinct small RNA pathway silences selfish genetic elements in the germline publication-title: Science doi: 10.1126/science.1129333 contributor: fullname: Vagin – volume: 12 start-page: 45 year: 2007 ident: 10.1016/j.cell.2009.07.014_bib28 article-title: Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response publication-title: Dev. Cell doi: 10.1016/j.devcel.2006.12.001 contributor: fullname: Klattenhoff – volume: 18 start-page: 147 year: 2008 ident: 10.1016/j.cell.2009.07.014_bib50 article-title: Argonaute loading improves the 5′ precision of both MicroRNAs and their miRNA strands in flies publication-title: Curr. Biol. doi: 10.1016/j.cub.2007.12.049 contributor: fullname: Seitz – volume: 59 start-page: 4375 year: 1999 ident: 10.1016/j.cell.2009.07.014_bib48 article-title: Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine publication-title: Cancer Res. contributor: fullname: Sarkaria – volume: 129 start-page: 37 year: 2007 ident: 10.1016/j.cell.2009.07.014_bib38 article-title: Mighty Piwis defend the germline against genome intruders publication-title: Cell doi: 10.1016/j.cell.2007.03.028 contributor: fullname: O'Donnell – volume: 1 start-page: e67 year: 2005 ident: 10.1016/j.cell.2009.07.014_bib22 article-title: All paired up with no place to go: pairing, synapsis, and DSB formation in a balancer heterozygote publication-title: PLoS Genet. doi: 10.1371/journal.pgen.0010067 contributor: fullname: Gong – volume: 105 start-page: 14964 year: 2008 ident: 10.1016/j.cell.2009.07.014_bib13 article-title: piRNA-mediated nuclear accumulation of retrotransposon transcripts in the Drosophila female germline publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0805943105 contributor: fullname: Chambeyron – volume: 120 start-page: 1201 year: 1994 ident: 10.1016/j.cell.2009.07.014_bib30 article-title: Localization of vasa protein to the Drosophila pole plasm is independent of its RNA-binding and helicase activities publication-title: Development doi: 10.1242/dev.120.5.1201 contributor: fullname: Liang – volume: 24 start-page: 1219 year: 2004 ident: 10.1016/j.cell.2009.07.014_bib8 article-title: Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.3.1219-1231.2004 contributor: fullname: Brodsky – volume: 316 start-page: 1586 year: 2007 ident: 10.1016/j.cell.2009.07.014_bib51 article-title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin publication-title: Science doi: 10.1126/science.1139815 contributor: fullname: Smith – volume: 3 start-page: e1526 year: 2008 ident: 10.1016/j.cell.2009.07.014_bib16 article-title: In Drosophila melanogaster the COM locus directs the somatic silencing of two retrotransposons through both Piwi-dependent and -independent pathways publication-title: PLoS ONE doi: 10.1371/journal.pone.0001526 contributor: fullname: Desset – volume: 129 start-page: 69 year: 2007 ident: 10.1016/j.cell.2009.07.014_bib26 article-title: A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish publication-title: Cell doi: 10.1016/j.cell.2007.03.026 contributor: fullname: Houwing – volume: 12 start-page: 2932 year: 1998 ident: 10.1016/j.cell.2009.07.014_bib35 article-title: mei-W68 in Drosophila melanogaster encodes a Spo11 homolog: evidence that the mechanism for initiating meiotic recombination is conserved publication-title: Genes Dev. doi: 10.1101/gad.12.18.2932 contributor: fullname: McKim – volume: 21 start-page: 2300 year: 2007 ident: 10.1016/j.cell.2009.07.014_bib9 article-title: Drosophila PIWI associates with chromatin and interacts directly with HP1a publication-title: Genes Dev. doi: 10.1101/gad.1564307 contributor: fullname: Brower-Toland – volume: 107 start-page: 611 year: 1984 ident: 10.1016/j.cell.2009.07.014_bib33 article-title: Organization and mapping of a sequence on the Drosophila melanogaster X and Y chromosomes that is transcribed during spermatogenesis publication-title: Genetics doi: 10.1093/genetics/107.4.611 contributor: fullname: Livak – volume: 30 start-page: 207 year: 2002 ident: 10.1016/j.cell.2009.07.014_bib17 article-title: Gene Expression Omnibus: NCBI gene expression and hybridization array data repository publication-title: Nucleic Acids Res. doi: 10.1093/nar/30.1.207 contributor: fullname: Edgar – volume: 137 start-page: 509 year: 2009 ident: 10.1016/j.cell.2009.07.014_bib29 article-title: Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies publication-title: Cell doi: 10.1016/j.cell.2009.04.027 contributor: fullname: Li – volume: 20 start-page: 2214 year: 2006 ident: 10.1016/j.cell.2009.07.014_bib47 article-title: Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome publication-title: Genes Dev. doi: 10.1101/gad.1454806 contributor: fullname: Saito – volume: 3 start-page: 730 year: 2001 ident: 10.1016/j.cell.2009.07.014_bib4 article-title: The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions publication-title: Nat. Cell Biol. doi: 10.1038/35087045 contributor: fullname: Blower – volume: 10 start-page: 94 year: 2009 ident: 10.1016/j.cell.2009.07.014_bib19 article-title: Small silencing RNAs: an expanding universe publication-title: Nat. Rev. Genet. doi: 10.1038/nrg2504 contributor: fullname: Ghildiyal – volume: 82 start-page: 815 year: 1995 ident: 10.1016/j.cell.2009.07.014_bib24 article-title: The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene publication-title: Cell doi: 10.1016/0092-8674(95)90478-6 contributor: fullname: Hari – volume: 138 start-page: 1181 year: 1994 ident: 10.1016/j.cell.2009.07.014_bib41 article-title: Genetic analysis of Stellate elements of Drosophila melanogaster publication-title: Genetics doi: 10.1093/genetics/138.4.1181 contributor: fullname: Palumbo – volume: 24 start-page: 498 year: 2007 ident: 10.1016/j.cell.2009.07.014_bib44 article-title: Restrictive flamenco alleles are maintained in Drosophila melanogaster population cages, despite the absence of their endogenous gypsy retroviral targets publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/msl176 contributor: fullname: Pelisson – volume: 116 start-page: 3069 year: 2003 ident: 10.1016/j.cell.2009.07.014_bib27 article-title: Relationship of DNA double-strand breaks to synapsis in Drosophila publication-title: J. Cell Sci. doi: 10.1242/jcs.00614 contributor: fullname: Jang – volume: 15 start-page: 285 year: 2008 ident: 10.1016/j.cell.2009.07.014_bib52 article-title: Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis publication-title: Dev. Cell doi: 10.1016/j.devcel.2008.05.015 contributor: fullname: Soper – volume: 320 start-page: 1077 year: 2008 ident: 10.1016/j.cell.2009.07.014_bib20 article-title: Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells publication-title: Science doi: 10.1126/science.1157396 contributor: fullname: Ghildiyal – volume: 12 start-page: 851 year: 2007 ident: 10.1016/j.cell.2009.07.014_bib42 article-title: zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline publication-title: Dev. Cell doi: 10.1016/j.devcel.2007.03.022 contributor: fullname: Pane – volume: 11 start-page: R229 year: 2001 ident: 10.1016/j.cell.2009.07.014_bib37 article-title: DNA repair: spot(light)s on chromatin publication-title: Curr. Biol. doi: 10.1016/S0960-9822(01)00112-9 contributor: fullname: Modesti – volume: 208 start-page: 613 year: 2006 ident: 10.1016/j.cell.2009.07.014_bib59 article-title: ATR dependent activation of Chk2 publication-title: J. Cell. Physiol. doi: 10.1002/jcp.20700 contributor: fullname: Wang – volume: 104 start-page: 6714 year: 2007 ident: 10.1016/j.cell.2009.07.014_bib31 article-title: Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0701920104 contributor: fullname: Lim – volume: 579 start-page: 5872 year: 2005 ident: 10.1016/j.cell.2009.07.014_bib56 article-title: RNAi-directed assembly of heterochromatin in fission yeast publication-title: FEBS Lett. doi: 10.1016/j.febslet.2005.08.083 contributor: fullname: Verdel – volume: 1 start-page: 96 year: 2005 ident: 10.1016/j.cell.2009.07.014_bib57 article-title: Positive selection drives the evolution of rhino, a member of the heterochromatin protein 1 family in Drosophila publication-title: PLoS Genet. doi: 10.1371/journal.pgen.0010009 contributor: fullname: Vermaak – volume: 316 start-page: 397 year: 2007 ident: 10.1016/j.cell.2009.07.014_bib32 article-title: piRNAs in the germ line publication-title: Science doi: 10.1126/science.1137543 contributor: fullname: Lin – volume: 98 start-page: 129 year: 1989 ident: 10.1016/j.cell.2009.07.014_bib3 article-title: Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitro publication-title: Chromosoma doi: 10.1007/BF00291049 contributor: fullname: Belmont – volume: 44 start-page: 489 year: 1994 ident: 10.1016/j.cell.2009.07.014_bib54 article-title: Immunofluorescence analysis of the cytoskeleton during oogenesis and early embryogenesis publication-title: Methods Cell Biol. doi: 10.1016/S0091-679X(08)60928-0 contributor: fullname: Theurkauf |
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| SubjectTerms | Animals Chromatin Immunoprecipitation Chromosomal Proteins, Non-Histone - metabolism DNA Transposable Elements Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Gene Silencing Heterochromatin - metabolism RNA RNA, Small Interfering - metabolism STEMCELL Transcription, Genetic |
| Title | The Drosophila HP1 Homolog Rhino Is Required for Transposon Silencing and piRNA Production by Dual-Strand Clusters |
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