The glycosylation status of the murine hepatitis coronavirus M protein affects the interferogenic capacity of the virus in vitro and its ability to replicate in the liver but not the brain

The coronavirus M protein, the most abundant coronaviral envelope component, is invariably glycosylated, which provides the virion with a diffuse, hydrophilic cover on its outer surface. Remarkably, while the group 1 and group 3 coronaviruses all have M proteins with N-linked sugars, the M proteins...

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Bibliographic Details
Published in:	Virology (New York, N.Y.) Vol. 312; no. 2; pp. 395 - 406
Main Authors:	de Haan, Cornelis A.M, de Wit, Marèl, Kuo, Lili, Montalto-Morrison, Cynthia, Haagmans, Bart L, Weiss, Susan R, Masters, Paul S, Rottier, Peter J.M
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-08-2003 Elsevier Science (USA)
Subjects:	Amino Acid Sequence Animals Base Sequence Brain - virology Coronavirus M Proteins Formaldehyde Gene Expression Regulation, Viral Genetic Engineering Glycosylation Interferon Type I - metabolism Liver - virology Mice Mice, Inbred Strains Murine hepatitis virus - genetics Murine hepatitis virus - growth & development Murine hepatitis virus - pathogenicity Murine hepatitis virus - physiology Mutation - genetics Phenotype Regular Viral Matrix Proteins - genetics Viral Matrix Proteins - metabolism Virus Replication
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