Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis
[Display omitted] •During acute viral hepatitis local IFN-I responses modulate liver inflammation.•IFNAR triggering of Kupffer cells protects against liver pathology during acute viral hepatitis.•Acute viral hepatitis induces Kupffer cell loss independently of direct infection.•Hepatitis-induced Kup...
Saved in:
| Published in: | Journal of hepatology Vol. 68; no. 4; pp. 682 - 690 |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Netherlands
Elsevier B.V
01-04-2018
Elsevier Science Ltd |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | [Display omitted]
•During acute viral hepatitis local IFN-I responses modulate liver inflammation.•IFNAR triggering of Kupffer cells protects against liver pathology during acute viral hepatitis.•Acute viral hepatitis induces Kupffer cell loss independently of direct infection.•Hepatitis-induced Kupffer cell loss is reversed by infiltrating blood monocytes.•In acute viral hepatitis IFNAR triggering of monocytes delays replenishment of monocyte-derived Kupffer cells.
Virus-induced fulminant hepatitis is a major cause of acute liver failure. During acute viral hepatitis the impact of type I interferon (IFN-I) on myeloid cells, including liver-resident Kupffer cells (KC), is only partially understood. Herein, we dissected the impact of locally induced IFN-I responses on myeloid cell function and hepatocytes during acute liver inflammation.
Two different DNA-encoded viruses, vaccinia virus (VACV) and murine cytomegalovirus (MCMV), were studied. In vivo imaging was applied to visualize local IFN-β induction and IFN-I receptor (IFNAR) triggering in VACV-infected reporter mice. Furthermore, mice with a cell type-selective IFNAR ablation were analyzed to dissect the role of IFNAR signaling in myeloid cells and hepatocytes. Experiments with Cx3cr1+/gfp mice revealed the origin of reconstituted KC. Finally, mixed bone marrow chimeric mice were studied to specifically analyze the effect of IFNAR triggering on liver infiltrating monocytes.
VACV infection induced local IFN-β responses, which lead to IFNAR signaling primarily within the liver. IFNAR triggering was needed to control the infection and prevent fulminant hepatitis. The severity of liver inflammation was independent of IFNAR triggering of hepatocytes, whereas IFNAR triggering of myeloid cells protected from excessive inflammation. Upon VACV or MCMV infection KC disappeared, whereas infiltrating monocytes differentiated to KC afterwards. During IFNAR triggering such replenished monocyte-derived KC comprised more IFNAR-deficient than -competent cells in mixed bone marrow chimeric mice, whereas after the decline of IFNAR triggering both subsets showed an even distribution.
Upon VACV infection IFNAR triggering of myeloid cells, but not of hepatocytes, critically modulates acute viral hepatitis. During infection with DNA-encoded viruses IFNAR triggering of liver-infiltrating blood monocytes delays the development of monocyte-derived KC, pointing towards new therapeutic strategies for acute viral hepatitis.
Viral infection can cause fulminant hepatitis, which in turn is a major cause of acute liver failure. Herein, we aimed to study the role of type 1 interferon responses in acute viral hepatitis. We identified that during infection with DNA-encoded viruses, type 1 interferon receptor triggering of blood monocytes delays the development of monocyte-derived Kupffer cells. This points to new therapeutic strategies for acute viral hepatitis. |
|---|---|
| AbstractList | BACKGROUND & AIMVirus-induced fulminant hepatitis is a major cause of acute liver failure. During acute viral hepatitis the impact of type I interferon (IFN-I) on myeloid cells, including liver-resident Kupffer cells (KC), is only partially understood. Herein, we dissected the impact of locally induced IFN-I responses on myeloid cell function and hepatocytes during acute liver inflammation. METHODSTwo different DNA-encoded viruses, vaccinia virus (VACV) and murine cytomegalovirus (MCMV), were studied. In vivo imaging was applied to visualize local IFN-β induction and IFN-I receptor (IFNAR) triggering in VACV-infected reporter mice. Furthermore, mice with a cell type-selective IFNAR ablation were analyzed to dissect the role of IFNAR signaling in myeloid cells and hepatocytes. Experiments with Cx3cr1+/gfp mice revealed the origin of reconstituted KC. Finally, mixed bone marrow chimeric mice were studied to specifically analyze the effect of IFNAR triggering on liver infiltrating monocytes. RESULTSVACV infection induced local IFN-β responses, which lead to IFNAR signaling primarily within the liver. IFNAR triggering was needed to control the infection and prevent fulminant hepatitis. The severity of liver inflammation was independent of IFNAR triggering of hepatocytes, whereas IFNAR triggering of myeloid cells protected from excessive inflammation. Upon VACV or MCMV infection KC disappeared, whereas infiltrating monocytes differentiated to KC afterwards. During IFNAR triggering such replenished monocyte-derived KC comprised more IFNAR-deficient than -competent cells in mixed bone marrow chimeric mice, whereas after the decline of IFNAR triggering both subsets showed an even distribution. CONCLUSIONUpon VACV infection IFNAR triggering of myeloid cells, but not of hepatocytes, critically modulates acute viral hepatitis. During infection with DNA-encoded viruses IFNAR triggering of liver-infiltrating blood monocytes delays the development of monocyte-derived KC, pointing towards new therapeutic strategies for acute viral hepatitis. LAY SUMMARYViral infection can cause fulminant hepatitis, which in turn is a major cause of acute liver failure. Herein, we aimed to study the role of type 1 interferon responses in acute viral hepatitis. We identified that during infection with DNA-encoded viruses, type 1 interferon receptor triggering of blood monocytes delays the development of monocyte-derived Kupffer cells. This points to new therapeutic strategies for acute viral hepatitis. Background & Aim Virus-induced fulminant hepatitis is a major cause of acute liver failure. During acute viral hepatitis the impact of type I interferon (IFN-I) on myeloid cells, including liver-resident Kupffer cells (KC), is only partially understood. Herein, we dissected the impact of locally induced IFN-I responses on myeloid cell function and hepatocytes during acute liver inflammation. Methods Two different DNA-encoded viruses, vaccinia virus (VACV) and murine cytomegalovirus (MCMV), were studied. In vivo imaging was applied to visualize local IFN-β induction and IFN-I receptor (IFNAR) triggering in VACV-infected reporter mice. Furthermore, mice with a cell type-selective IFNAR ablation were analyzed to dissect the role of IFNAR signaling in myeloid cells and hepatocytes. Experiments with Cx3cr1+/gfp mice revealed the origin of reconstituted KC. Finally, mixed bone marrow chimeric mice were studied to specifically analyze the effect of IFNAR triggering on liver infiltrating monocytes. Results VACV infection induced local IFN-β responses, which lead to IFNAR signaling primarily within the liver. IFNAR triggering was needed to control the infection and prevent fulminant hepatitis. The severity of liver inflammation was independent of IFNAR triggering of hepatocytes, whereas IFNAR triggering of myeloid cells protected from excessive inflammation. Upon VACV or MCMV infection KC disappeared, whereas infiltrating monocytes differentiated to KC afterwards. During IFNAR triggering such replenished monocyte-derived KC comprised more IFNAR-deficient than -competent cells in mixed bone marrow chimeric mice, whereas after the decline of IFNAR triggering both subsets showed an even distribution. Conclusion Upon VACV infection IFNAR triggering of myeloid cells, but not of hepatocytes, critically modulates acute viral hepatitis. During infection with DNA-encoded viruses IFNAR triggering of liver-infiltrating blood monocytes delays the development of monocyte-derived KC, pointing towards new therapeutic strategies for acute viral hepatitis. [Display omitted] •During acute viral hepatitis local IFN-I responses modulate liver inflammation.•IFNAR triggering of Kupffer cells protects against liver pathology during acute viral hepatitis.•Acute viral hepatitis induces Kupffer cell loss independently of direct infection.•Hepatitis-induced Kupffer cell loss is reversed by infiltrating blood monocytes.•In acute viral hepatitis IFNAR triggering of monocytes delays replenishment of monocyte-derived Kupffer cells. Virus-induced fulminant hepatitis is a major cause of acute liver failure. During acute viral hepatitis the impact of type I interferon (IFN-I) on myeloid cells, including liver-resident Kupffer cells (KC), is only partially understood. Herein, we dissected the impact of locally induced IFN-I responses on myeloid cell function and hepatocytes during acute liver inflammation. Two different DNA-encoded viruses, vaccinia virus (VACV) and murine cytomegalovirus (MCMV), were studied. In vivo imaging was applied to visualize local IFN-β induction and IFN-I receptor (IFNAR) triggering in VACV-infected reporter mice. Furthermore, mice with a cell type-selective IFNAR ablation were analyzed to dissect the role of IFNAR signaling in myeloid cells and hepatocytes. Experiments with Cx3cr1+/gfp mice revealed the origin of reconstituted KC. Finally, mixed bone marrow chimeric mice were studied to specifically analyze the effect of IFNAR triggering on liver infiltrating monocytes. VACV infection induced local IFN-β responses, which lead to IFNAR signaling primarily within the liver. IFNAR triggering was needed to control the infection and prevent fulminant hepatitis. The severity of liver inflammation was independent of IFNAR triggering of hepatocytes, whereas IFNAR triggering of myeloid cells protected from excessive inflammation. Upon VACV or MCMV infection KC disappeared, whereas infiltrating monocytes differentiated to KC afterwards. During IFNAR triggering such replenished monocyte-derived KC comprised more IFNAR-deficient than -competent cells in mixed bone marrow chimeric mice, whereas after the decline of IFNAR triggering both subsets showed an even distribution. Upon VACV infection IFNAR triggering of myeloid cells, but not of hepatocytes, critically modulates acute viral hepatitis. During infection with DNA-encoded viruses IFNAR triggering of liver-infiltrating blood monocytes delays the development of monocyte-derived KC, pointing towards new therapeutic strategies for acute viral hepatitis. Viral infection can cause fulminant hepatitis, which in turn is a major cause of acute liver failure. Herein, we aimed to study the role of type 1 interferon responses in acute viral hepatitis. We identified that during infection with DNA-encoded viruses, type 1 interferon receptor triggering of blood monocytes delays the development of monocyte-derived Kupffer cells. This points to new therapeutic strategies for acute viral hepatitis. Virus-induced fulminant hepatitis is a major cause of acute liver failure. During acute viral hepatitis the impact of type I interferon (IFN-I) on myeloid cells, including liver-resident Kupffer cells (KC), is only partially understood. Herein, we dissected the impact of locally induced IFN-I responses on myeloid cell function and hepatocytes during acute liver inflammation. Two different DNA-encoded viruses, vaccinia virus (VACV) and murine cytomegalovirus (MCMV), were studied. In vivo imaging was applied to visualize local IFN-β induction and IFN-I receptor (IFNAR) triggering in VACV-infected reporter mice. Furthermore, mice with a cell type-selective IFNAR ablation were analyzed to dissect the role of IFNAR signaling in myeloid cells and hepatocytes. Experiments with Cx3cr1 mice revealed the origin of reconstituted KC. Finally, mixed bone marrow chimeric mice were studied to specifically analyze the effect of IFNAR triggering on liver infiltrating monocytes. VACV infection induced local IFN-β responses, which lead to IFNAR signaling primarily within the liver. IFNAR triggering was needed to control the infection and prevent fulminant hepatitis. The severity of liver inflammation was independent of IFNAR triggering of hepatocytes, whereas IFNAR triggering of myeloid cells protected from excessive inflammation. Upon VACV or MCMV infection KC disappeared, whereas infiltrating monocytes differentiated to KC afterwards. During IFNAR triggering such replenished monocyte-derived KC comprised more IFNAR-deficient than -competent cells in mixed bone marrow chimeric mice, whereas after the decline of IFNAR triggering both subsets showed an even distribution. Upon VACV infection IFNAR triggering of myeloid cells, but not of hepatocytes, critically modulates acute viral hepatitis. During infection with DNA-encoded viruses IFNAR triggering of liver-infiltrating blood monocytes delays the development of monocyte-derived KC, pointing towards new therapeutic strategies for acute viral hepatitis. Viral infection can cause fulminant hepatitis, which in turn is a major cause of acute liver failure. Herein, we aimed to study the role of type 1 interferon responses in acute viral hepatitis. We identified that during infection with DNA-encoded viruses, type 1 interferon receptor triggering of blood monocytes delays the development of monocyte-derived Kupffer cells. This points to new therapeutic strategies for acute viral hepatitis. |
| Author | Heikenwaelder, Mathias Skerra, Jennifer Ghita, Luca Kalinke, Ulrich Lienenklaus, Stefan Borst, Katharina Sutter, Gerd Köster, Mario Frenz, Theresa Spanier, Julia Chhatbar, Chintan Tegtmeyer, Pia-Katharina Namineni, Sukumar |
| Author_xml | – sequence: 1 givenname: Katharina surname: Borst fullname: Borst, Katharina organization: Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hanover Medical School and the Helmholtz Centre for Infection Research, Brunswick, Germany – sequence: 2 givenname: Theresa surname: Frenz fullname: Frenz, Theresa organization: Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hanover Medical School and the Helmholtz Centre for Infection Research, Brunswick, Germany – sequence: 3 givenname: Julia surname: Spanier fullname: Spanier, Julia organization: Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hanover Medical School and the Helmholtz Centre for Infection Research, Brunswick, Germany – sequence: 4 givenname: Pia-Katharina surname: Tegtmeyer fullname: Tegtmeyer, Pia-Katharina organization: Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hanover Medical School and the Helmholtz Centre for Infection Research, Brunswick, Germany – sequence: 5 givenname: Chintan surname: Chhatbar fullname: Chhatbar, Chintan organization: Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hanover Medical School and the Helmholtz Centre for Infection Research, Brunswick, Germany – sequence: 6 givenname: Jennifer surname: Skerra fullname: Skerra, Jennifer organization: Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hanover Medical School and the Helmholtz Centre for Infection Research, Brunswick, Germany – sequence: 7 givenname: Luca surname: Ghita fullname: Ghita, Luca organization: Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hanover Medical School and the Helmholtz Centre for Infection Research, Brunswick, Germany – sequence: 8 givenname: Sukumar surname: Namineni fullname: Namineni, Sukumar organization: Department Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany – sequence: 9 givenname: Stefan surname: Lienenklaus fullname: Lienenklaus, Stefan organization: Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hanover Medical School and the Helmholtz Centre for Infection Research, Brunswick, Germany – sequence: 10 givenname: Mario surname: Köster fullname: Köster, Mario organization: Research Group Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, Brunswick, Germany – sequence: 11 givenname: Mathias surname: Heikenwaelder fullname: Heikenwaelder, Mathias organization: Department Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany – sequence: 12 givenname: Gerd surname: Sutter fullname: Sutter, Gerd organization: Institute for Infectious Diseases and Zoonoses, Ludwig-Maximilians University, Munich, Germany – sequence: 13 givenname: Ulrich surname: Kalinke fullname: Kalinke, Ulrich email: Ulrich.Kalinke@twincore.de organization: Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hanover Medical School and the Helmholtz Centre for Infection Research, Brunswick, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29274730$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kcFq3DAQhkVJaDZpX6CHIuilFzsjyWvZ0EsJaRMayCU5C1kaJzK27EpyYN--Mpv20ENOA-Kbb0bzn5MTP3sk5BODkgGrL4dyeMal5MBkyVgJvH1HdqwGKKCu2AnZZagpGi6bM3Ie4wAAAtrqPTnjLZeVFLAj08NhQXpLnU8YegyzpwENLmkONLonr0fnn6jFUR8i_bUufWaowXHM2DKid_F5Qp-oXcMGarMmpP06Ts7r_Pzigh5p3lInl1z8QE57PUb8-FovyOOP64erm-Lu_uft1fe7wlRtlYqWa1E1nGOP3V4wyQGMbLq2Acl6K5mp9qLrpLQdCit4V3fW7DnvGiGwFaYRF-Tr0buE-feKManJxW1r7XFeo2JZxYDXDWT0y3_oMK8h_zsqDrIWeTjfhPxImTDHGLBXS3CTDgfFQG1hqEFtYagtDMWYymHkps-v6rWb0P5r-Xv9DHw7Aphv8eIwqGgceoPW5RCSsrN7y_8Hg-2dqQ |
| CitedBy_id | crossref_primary_10_1016_j_jhep_2018_11_018 crossref_primary_10_18632_oncotarget_27906 crossref_primary_10_3748_wjg_v28_i4_479 crossref_primary_10_1093_discim_kyad008 crossref_primary_10_1016_j_jcmgh_2022_01_015 crossref_primary_10_1002_jnr_24333 crossref_primary_10_3390_pharmaceutics14091907 crossref_primary_10_1016_j_jhep_2018_01_011 crossref_primary_10_3389_fimmu_2019_02852 crossref_primary_10_3389_fimmu_2021_690813 crossref_primary_10_1172_JCI150489 crossref_primary_10_3390_cancers16091772 crossref_primary_10_3390_ijms22094726 crossref_primary_10_1038_s41423_020_00558_8 crossref_primary_10_1371_journal_ppat_1009593 crossref_primary_10_1038_s41420_020_00299_7 crossref_primary_10_1371_journal_ppat_1010474 crossref_primary_10_1016_j_apsb_2024_05_001 crossref_primary_10_1538_expanim_20_0014 crossref_primary_10_3389_fcell_2023_1171317 crossref_primary_10_7717_peerj_12579 crossref_primary_10_3389_fimmu_2022_892114 crossref_primary_10_1038_s12276_022_00921_x crossref_primary_10_1038_s41419_022_05487_0 crossref_primary_10_1038_s41419_023_06268_z crossref_primary_10_1016_j_biopha_2021_111614 crossref_primary_10_3389_fphar_2023_1265935 crossref_primary_10_1016_j_jhep_2019_05_012 crossref_primary_10_1016_j_jhep_2018_12_016 crossref_primary_10_1186_s13287_023_03370_z crossref_primary_10_1016_j_jhep_2018_12_034 crossref_primary_10_1016_j_jhep_2019_03_016 crossref_primary_10_3389_fimmu_2022_940867 crossref_primary_10_3389_fimmu_2023_1238452 crossref_primary_10_1038_s41423_021_00731_7 crossref_primary_10_12677_ACM_2021_117433 crossref_primary_10_1016_j_metabol_2020_154220 crossref_primary_10_12677_ACM_2024_142525 crossref_primary_10_1016_j_immuni_2022_08_002 crossref_primary_10_1089_vim_2020_0024 |
| Cites_doi | 10.1111/j.1600-0676.1984.tb00926.x 10.1186/1471-213X-1-4 10.1128/JVI.74.23.11230-11239.2000 10.1159/000444915 10.1128/JVI.01617-08 10.3791/2710 10.1038/ni.2691 10.1038/nri3787 10.4049/jimmunol.174.3.1549 10.1128/JVI.00545-11 10.1002/eji.201040453 10.1111/cei.12368 10.1016/j.immuni.2014.12.020 10.1016/j.ejcb.2011.02.002 10.1146/annurev-virology-100114-055249 10.1189/jlb.1111566 10.12998/wjcc.v3.i2.125 10.1128/JVI.03117-13 10.1002/hep.27793 10.1002/hep.23640 10.1089/jir.2009.0064 10.1186/1743-422X-5-47 10.4049/jimmunol.131.3.1531 10.1016/j.immuni.2008.03.011 10.4049/jimmunol.0804277 10.1126/science.7660125 10.1074/jbc.274.1.305 10.1016/j.jhep.2006.02.006 10.1038/ncomms10321 10.1016/j.chom.2007.12.008 10.1128/JVI.03733-14 10.1084/jem.20141539 10.1128/MCB.20.11.4106-4114.2000 10.1073/pnas.1119964109 10.4049/jimmunol.182.2.1099 10.1016/j.immuni.2012.12.001 10.1016/j.jhep.2016.05.037 10.1128/JVI.00216-14 10.1126/science.8009221 10.1099/vir.0.055921-0 10.1128/JVI.00303-10 10.1038/nri.2017.42 10.1038/nature13989 10.1046/j.1440-1827.1999.00910.x 10.1002/hep.26915 10.1182/blood-2006-06-027599 10.1038/cmi.2015.104 10.1016/j.immuni.2015.10.013 |
| ContentType | Journal Article |
| Copyright | 2017 European Association for the Study of the Liver Copyright © 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. Copyright Elsevier Science Ltd. Apr 2018 |
| Copyright_xml | – notice: 2017 European Association for the Study of the Liver – notice: Copyright © 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. – notice: Copyright Elsevier Science Ltd. Apr 2018 |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7T5 H94 7X8 |
| DOI | 10.1016/j.jhep.2017.11.029 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Immunology Abstracts AIDS and Cancer Research Abstracts MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef AIDS and Cancer Research Abstracts Immunology Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic AIDS and Cancer Research Abstracts MEDLINE |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1600-0641 |
| EndPage | 690 |
| ExternalDocumentID | 10_1016_j_jhep_2017_11_029 29274730 S016882781732473X |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M .1- .55 .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29K 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQQT AAQXK AAXUO ABBQC ABFNM ABFRF ABJNI ABLVK ABMAC ABMZM ABXDB ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEFWE AEKER AENEX AEVXI AFCTW AFFNX AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AHPSJ AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 D-I DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HDZ HMK HMO HVGLF HX~ HZ~ IHE J1W KOM LCYCR LZ1 M27 M41 MJL MO0 N9A O-L O9- OAUVE OC. ON0 OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SPCBC SSH SSZ T5K TEORI UV1 WUQ X7M YOC Z5R ZGI ~G- AAXKI ADVLN AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7T5 H94 7X8 |
| ID | FETCH-LOGICAL-c494t-92a34822efeb5317200c78b98071fd71c453bb77dbe3d32b6bdc522b833e93c83 |
| ISSN | 0168-8278 |
| IngestDate | Sun Sep 29 07:42:06 EDT 2024 Thu Oct 10 19:54:16 EDT 2024 Thu Sep 26 17:30:56 EDT 2024 Sat Sep 28 08:29:32 EDT 2024 Fri Feb 23 02:28:16 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Innate immunity Monocyte infiltration DNA virus infection Liver inflammation |
| Language | English |
| License | Copyright © 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c494t-92a34822efeb5317200c78b98071fd71c453bb77dbe3d32b6bdc522b833e93c83 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://repository.helmholtz-hzi.de/bitstream/10033/621432/1/Borst%20et%20al_manuscript.pdf |
| PMID | 29274730 |
| PQID | 2076372028 |
| PQPubID | 2047556 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_1980102680 proquest_journals_2076372028 crossref_primary_10_1016_j_jhep_2017_11_029 pubmed_primary_29274730 elsevier_sciencedirect_doi_10_1016_j_jhep_2017_11_029 |
| PublicationCentury | 2000 |
| PublicationDate | April 2018 2018-04-00 20180401 |
| PublicationDateYYYYMMDD | 2018-04-01 |
| PublicationDate_xml | – month: 04 year: 2018 text: April 2018 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands – name: Amsterdam |
| PublicationTitle | Journal of hepatology |
| PublicationTitleAlternate | J Hepatol |
| PublicationYear | 2018 |
| Publisher | Elsevier B.V Elsevier Science Ltd |
| Publisher_xml | – name: Elsevier B.V – name: Elsevier Science Ltd |
| References | Conrad, Resch, Gogesch, Kalinke, Bechmann, Bogdan (b0110) 2014; 59 Jung, Aliberti, Graemmel, Sunshine, Kreutzberg, Sher (b0170) 2000; 20 Bukowski, Woda, Habu, Okumura, Welsh (b0140) 1983; 131 Pulverer, Rand, Lienenklaus, Kugel, Zietara, Kochs (b0165) 2010; 84 Hokeness, Kuziel, Biron, Salazar-Mather (b0105) 2005; 174 Ramachandran, Pellicoro, Vernon, Boulter, Aucott, Ali (b0080) 2012; 109 Guilliams, Scott (b0245) 2017; 17 Jenne, Kubes (b0055) 2013; 14 Schneider, Loewendorf, De Trez, Fulton, Rhode, Shumway (b0220) 2008; 3 Armengol, Bartoli, Sanjurjo, Serra, Amezaga, Sala (b0060) 2013; 33 Drebber, Kasper, Krupacz, Haferkamp, Kern, Steffen (b0015) 2006; 44 Kamphuis, Junt, Waibler, Forster, Kalinke (b0190) 2006; 108 Ebe, Hasegawa, Takatsuka, Umezu, Mitsuyama, Arakawa (b0070) 1999; 49 Movita, van de Garde (b0075) 2015; 89 Ten Napel, Houthoff, The (b0025) 1984; 4 Yona, Kim, Wolf, Mildner, Varol, Breker (b0030) 2013; 38 Movita, Kreefft, Biesta, van Oudenaren, Leenen, Janssen (b0050) 2012; 92 Sacher, Mohr, Weyn, Schlichting, Koszinowski, Ruzsics (b0145) 2012; 91 Li, Hofer, Jung, Lim, Campbell (b0120) 2014; 88 Rafailidis, Mourtzoukou, Varbobitis, Falagas (b0235) 2008; 5 Kuhn, Schwenk, Aguet, Rajewsky (b0175) 1995; 269 Prinz, Schmidt, Mildner, Knobeloch, Hanisch, Raasch (b0195) 2008; 28 Lind, Svedin, Utorova, Stone, Flodstrom-Tullberg (b0020) 2014; 177 Lienenklaus, Cornitescu, Zietara, Lyszkiewicz, Gekara, Jablonska (b0160) 2009; 183 Bleriot, Dupuis, Jouvion, Eberl, Disson, Lecuit (b0240) 2015; 42 McNab, Mayer-Barber, Sher, Wack, O'Garra (b0095) 2015; 15 Gomez Perdiguero, Klapproth, Schulz, Busch, Azzoni, Crozet (b0035) 2015; 518 Muller, Steinhoff, Reis, Hemmi, Pavlovic, Zinkernagel (b0155) 1994; 264 Srinivas, Watanabe, Lin, William, Tanabe, Jessell (b0180) 2001; 1 Dal-Secco, Wang, Zeng, Kolaczkowska, Wong, Petri (b0085) 2015; 212 Bhattacharya, Hegazy, Deigendesch, Kosack, Cupovic, Kandasamy (b0115) 2015; 43 Lang, Recher, Honke, Scheu, Borkens, Gailus (b0065) 2010; 52 Alcami, Symons, Smith (b0125) 2000; 74 Scott, Zheng, De Baetselier, Martens, Saeys, De Prijck (b0210) 2016; 7 Frenz, Waibler, Hofmann, Hamdorf, Lantermann, Reizis (b0150) 2010; 40 Cervantes-Barragan, Kalinke, Zust, Konig, Reizis, Lopez-Macias (b0100) 2009; 182 Samanta, Sharma (b0010) 2015; 3 Maschmeyer, Flach, Winau (b0205) 2011 Ju, Tacke (b0040) 2016; 13 Heymann, Peusquens, Ludwig-Portugall, Kohlhepp, Ergen, Niemietz (b0045) 2015; 62 Waibler, Anzaghe, Frenz, Schwantes, Pohlmann, Ludwig (b0130) 2009; 83 Döring, Lessin, Frenz, Spanier, Kessler, Tegtmeyer (b0225) 2014; 88 Jordan, Krause, Prager, Mitrovic, Jonjic, Koszinowski (b0200) 2011; 85 Beattie, Sawtell, Mann, Frame, Teal, de Labastida Rivera (b0215) 2016; 65 Postic, Shiota, Niswender, Jetton, Chen, Moates (b0185) 1999; 274 Marshall, Geballe (b0135) 2009; 29 Manka, Verheyen, Gerken, Canbay (b0005) 2016; 32 Smith, Benfield, Maluquer de Motes, Mazzon, Ember, Ferguson (b0230) 2013; 94 Fensterl, Chattopadhyay, Sen (b0090) 2015; 2 30686611 - J Hepatol. 2019 Apr;70(4):813-815 30712975 - J Hepatol. 2019 Apr;70(4):815-816 29463431 - J Hepatol. 2018 Apr;68(4):635-637 Ebe (10.1016/j.jhep.2017.11.029_b0070) 1999; 49 Waibler (10.1016/j.jhep.2017.11.029_b0130) 2009; 83 McNab (10.1016/j.jhep.2017.11.029_b0095) 2015; 15 Jung (10.1016/j.jhep.2017.11.029_b0170) 2000; 20 Ju (10.1016/j.jhep.2017.11.029_b0040) 2016; 13 Cervantes-Barragan (10.1016/j.jhep.2017.11.029_b0100) 2009; 182 Postic (10.1016/j.jhep.2017.11.029_b0185) 1999; 274 Ramachandran (10.1016/j.jhep.2017.11.029_b0080) 2012; 109 Lienenklaus (10.1016/j.jhep.2017.11.029_b0160) 2009; 183 Srinivas (10.1016/j.jhep.2017.11.029_b0180) 2001; 1 Kuhn (10.1016/j.jhep.2017.11.029_b0175) 1995; 269 Conrad (10.1016/j.jhep.2017.11.029_b0110) 2014; 59 Lang (10.1016/j.jhep.2017.11.029_b0065) 2010; 52 Armengol (10.1016/j.jhep.2017.11.029_b0060) 2013; 33 Pulverer (10.1016/j.jhep.2017.11.029_b0165) 2010; 84 Ten Napel (10.1016/j.jhep.2017.11.029_b0025) 1984; 4 Frenz (10.1016/j.jhep.2017.11.029_b0150) 2010; 40 Jenne (10.1016/j.jhep.2017.11.029_b0055) 2013; 14 Bhattacharya (10.1016/j.jhep.2017.11.029_b0115) 2015; 43 Sacher (10.1016/j.jhep.2017.11.029_b0145) 2012; 91 Beattie (10.1016/j.jhep.2017.11.029_b0215) 2016; 65 Li (10.1016/j.jhep.2017.11.029_b0120) 2014; 88 Scott (10.1016/j.jhep.2017.11.029_b0210) 2016; 7 Jordan (10.1016/j.jhep.2017.11.029_b0200) 2011; 85 Muller (10.1016/j.jhep.2017.11.029_b0155) 1994; 264 Movita (10.1016/j.jhep.2017.11.029_b0075) 2015; 89 Bleriot (10.1016/j.jhep.2017.11.029_b0240) 2015; 42 Kamphuis (10.1016/j.jhep.2017.11.029_b0190) 2006; 108 Smith (10.1016/j.jhep.2017.11.029_b0230) 2013; 94 Yona (10.1016/j.jhep.2017.11.029_b0030) 2013; 38 Dal-Secco (10.1016/j.jhep.2017.11.029_b0085) 2015; 212 Fensterl (10.1016/j.jhep.2017.11.029_b0090) 2015; 2 Alcami (10.1016/j.jhep.2017.11.029_b0125) 2000; 74 Maschmeyer (10.1016/j.jhep.2017.11.029_b0205) 2011 Movita (10.1016/j.jhep.2017.11.029_b0050) 2012; 92 Heymann (10.1016/j.jhep.2017.11.029_b0045) 2015; 62 Gomez Perdiguero (10.1016/j.jhep.2017.11.029_b0035) 2015; 518 Lind (10.1016/j.jhep.2017.11.029_b0020) 2014; 177 Prinz (10.1016/j.jhep.2017.11.029_b0195) 2008; 28 Bukowski (10.1016/j.jhep.2017.11.029_b0140) 1983; 131 Manka (10.1016/j.jhep.2017.11.029_b0005) 2016; 32 Döring (10.1016/j.jhep.2017.11.029_b0225) 2014; 88 Marshall (10.1016/j.jhep.2017.11.029_b0135) 2009; 29 Rafailidis (10.1016/j.jhep.2017.11.029_b0235) 2008; 5 Guilliams (10.1016/j.jhep.2017.11.029_b0245) 2017; 17 Schneider (10.1016/j.jhep.2017.11.029_b0220) 2008; 3 Drebber (10.1016/j.jhep.2017.11.029_b0015) 2006; 44 Samanta (10.1016/j.jhep.2017.11.029_b0010) 2015; 3 Hokeness (10.1016/j.jhep.2017.11.029_b0105) 2005; 174 |
| References_xml | – volume: 264 start-page: 1918 year: 1994 end-page: 1921 ident: b0155 article-title: Functional role of type I and type II interferons in antiviral defense publication-title: Science contributor: fullname: Zinkernagel – volume: 94 start-page: 2367 year: 2013 end-page: 2392 ident: b0230 article-title: Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity publication-title: J Gen Virol contributor: fullname: Ferguson – volume: 88 start-page: 7578 year: 2014 end-page: 7588 ident: b0120 article-title: IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus publication-title: J Virol contributor: fullname: Campbell – volume: 2 start-page: 549 year: 2015 end-page: 572 ident: b0090 article-title: No love lost between viruses and interferons publication-title: Annu Rev Virol contributor: fullname: Sen – volume: 518 start-page: 547 year: 2015 end-page: 551 ident: b0035 article-title: Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors publication-title: Nature contributor: fullname: Crozet – volume: 108 start-page: 3253 year: 2006 end-page: 3261 ident: b0190 article-title: Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia publication-title: Blood contributor: fullname: Kalinke – volume: 15 start-page: 87 year: 2015 end-page: 103 ident: b0095 article-title: Type I interferons in infectious disease publication-title: Nat Rev Immunol contributor: fullname: O'Garra – volume: 3 start-page: 67 year: 2008 end-page: 76 ident: b0220 article-title: Lymphotoxin-mediated crosstalk between B cells and splenic stroma promotes the initial type I interferon response to cytomegalovirus publication-title: Cell Host Microbe contributor: fullname: Shumway – volume: 131 start-page: 1531 year: 1983 end-page: 1538 ident: b0140 article-title: Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo publication-title: J Immunol contributor: fullname: Welsh – volume: 49 start-page: 519 year: 1999 end-page: 532 ident: b0070 article-title: The role of Kupffer cells and regulation of neutrophil migration into the liver by macrophage inflammatory protein-2 in primary listeriosis in mice publication-title: Pathol Int contributor: fullname: Arakawa – volume: 83 start-page: 1563 year: 2009 end-page: 1571 ident: b0130 article-title: Vaccinia virus-mediated inhibition of type I interferon responses is a multifactorial process involving the soluble type I interferon receptor B18 and intracellular components publication-title: J Virol contributor: fullname: Ludwig – volume: 274 start-page: 305 year: 1999 end-page: 315 ident: b0185 article-title: Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase publication-title: J Biol Chem contributor: fullname: Moates – volume: 182 start-page: 1099 year: 2009 end-page: 1106 ident: b0100 article-title: Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection publication-title: J Immunol contributor: fullname: Lopez-Macias – volume: 43 start-page: 974 year: 2015 end-page: 986 ident: b0115 article-title: Superoxide dismutase 1 protects hepatocytes from type i interferon-driven oxidative damage publication-title: Immunity contributor: fullname: Kandasamy – volume: 33 start-page: 57 year: 2013 end-page: 96 ident: b0060 article-title: Role of scavenger receptors in the pathophysiology of chronic liver diseases publication-title: Crit Rev Immunol contributor: fullname: Sala – volume: 44 start-page: 879 year: 2006 end-page: 885 ident: b0015 article-title: The role of Epstein-Barr virus in acute and chronic hepatitis publication-title: J Hepatol contributor: fullname: Steffen – volume: 212 start-page: 447 year: 2015 end-page: 456 ident: b0085 article-title: A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury publication-title: J Exp Med contributor: fullname: Petri – volume: 62 start-page: 279 year: 2015 end-page: 291 ident: b0045 article-title: Liver inflammation abrogates immunological tolerance induced by Kupffer cells publication-title: Hepatology contributor: fullname: Niemietz – volume: 1 start-page: 4 year: 2001 ident: b0180 article-title: Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus publication-title: BMC Dev Biol contributor: fullname: Jessell – volume: 7 start-page: 10321 year: 2016 ident: b0210 article-title: Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells publication-title: Nat Commun contributor: fullname: De Prijck – volume: 65 start-page: 758 year: 2016 end-page: 768 ident: b0215 article-title: Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions publication-title: J Hepatol contributor: fullname: de Labastida Rivera – volume: 17 start-page: 451 year: 2017 end-page: 460 ident: b0245 article-title: Does niche competition determine the origin of tissue-resident macrophages? publication-title: Nat Rev Immunol contributor: fullname: Scott – year: 2011 ident: b0205 article-title: Seven steps to stellate cells publication-title: J Vis Exp contributor: fullname: Winau – volume: 42 start-page: 145 year: 2015 end-page: 158 ident: b0240 article-title: Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection publication-title: Immunity contributor: fullname: Lecuit – volume: 14 start-page: 996 year: 2013 end-page: 1006 ident: b0055 article-title: Immune surveillance by the liver publication-title: Nat Immunol contributor: fullname: Kubes – volume: 52 start-page: 25 year: 2010 end-page: 32 ident: b0065 article-title: Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice publication-title: Hepatology contributor: fullname: Gailus – volume: 109 start-page: E3186 year: 2012 end-page: E3195 ident: b0080 article-title: Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis publication-title: Proc Natl Acad Sci U S A contributor: fullname: Ali – volume: 3 start-page: 125 year: 2015 end-page: 131 ident: b0010 article-title: Dengue and its effects on liver publication-title: World J Clin Cases contributor: fullname: Sharma – volume: 174 start-page: 1549 year: 2005 end-page: 1556 ident: b0105 article-title: Monocyte chemoattractant protein-1 and CCR2 interactions are required for IFN-/-induced inflammatory responses and antiviral defense in liver publication-title: J Immunol contributor: fullname: Salazar-Mather – volume: 91 start-page: 70 year: 2012 end-page: 77 ident: b0145 article-title: The role of cell types in cytomegalovirus infection in vivo publication-title: Eur J Cell Biol contributor: fullname: Ruzsics – volume: 269 start-page: 1427 year: 1995 end-page: 1429 ident: b0175 article-title: Inducible gene targeting in mice publication-title: Science contributor: fullname: Rajewsky – volume: 38 start-page: 79 year: 2013 end-page: 91 ident: b0030 article-title: Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis publication-title: Immunity contributor: fullname: Breker – volume: 85 start-page: 10346 year: 2011 end-page: 10353 ident: b0200 article-title: Virus progeny of murine cytomegalovirus bacterial artificial chromosome pSM3fr show reduced growth in salivary Glands due to a fixed mutation of MCK-2 publication-title: J Virol contributor: fullname: Koszinowski – volume: 89 start-page: 4809 year: 2015 end-page: 4817 ident: b0075 article-title: Inflammatory monocytes recruited to the liver within 24 h after virus-induced inflammation resemble Kupffer cells but are functionally distinct publication-title: J Virol contributor: fullname: van de Garde – volume: 84 start-page: 8626 year: 2010 end-page: 8638 ident: b0165 article-title: Temporal and spatial resolution of type I and III interferon responses in vivo publication-title: J Virol contributor: fullname: Kochs – volume: 88 start-page: 13638 year: 2014 end-page: 13650 ident: b0225 article-title: M27 expressed by cytomegalovirus counteracts effective type I interferon induction of myeloid cells but not of plasmacytoid dendritic cells publication-title: J Virol contributor: fullname: Tegtmeyer – volume: 5 start-page: 47 year: 2008 ident: b0235 article-title: Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review publication-title: Virol J contributor: fullname: Falagas – volume: 32 start-page: 80 year: 2016 end-page: 85 ident: b0005 article-title: Liver failure due to acute viral hepatitis (A-E) publication-title: Visc Med contributor: fullname: Canbay – volume: 29 start-page: 609 year: 2009 end-page: 619 ident: b0135 article-title: Multifaceted evasion of the interferon response by cytomegalovirus publication-title: J Interferon Cytokine Res contributor: fullname: Geballe – volume: 59 start-page: 1555 year: 2014 end-page: 1563 ident: b0110 article-title: Protection against RNA-induced liver damage by myeloid cells requires type I interferon and IL-1 receptor antagonist in mice publication-title: Hepatology contributor: fullname: Bogdan – volume: 177 start-page: 687 year: 2014 end-page: 695 ident: b0020 article-title: Type III interferons are expressed by Coxsackievirus-infected human primary hepatocytes and regulate hepatocyte permissiveness to infection publication-title: Clin Exp Immunol contributor: fullname: Flodstrom-Tullberg – volume: 20 start-page: 4106 year: 2000 end-page: 4114 ident: b0170 article-title: Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion publication-title: Mol Cell Biol contributor: fullname: Sher – volume: 183 start-page: 3229 year: 2009 end-page: 3236 ident: b0160 article-title: Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo publication-title: J Immunol contributor: fullname: Jablonska – volume: 74 start-page: 11230 year: 2000 end-page: 11239 ident: b0125 article-title: The vaccinia virus soluble alpha/beta interferon (IFN) receptor binds to the cell surface and protects cells from the antiviral effects of IFN publication-title: J Virol contributor: fullname: Smith – volume: 28 start-page: 675 year: 2008 end-page: 686 ident: b0195 article-title: Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system publication-title: Immunity contributor: fullname: Raasch – volume: 92 start-page: 723 year: 2012 end-page: 733 ident: b0050 article-title: Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages publication-title: J Leukoc Biol contributor: fullname: Janssen – volume: 4 start-page: 184 year: 1984 end-page: 194 ident: b0025 article-title: Cytomegalovirus hepatitis in normal and immune compromised hosts publication-title: Liver contributor: fullname: The – volume: 13 start-page: 316 year: 2016 end-page: 327 ident: b0040 article-title: Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies publication-title: Cell Mol Immunol contributor: fullname: Tacke – volume: 40 start-page: 2769 year: 2010 end-page: 2777 ident: b0150 article-title: Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion publication-title: Eur J Immunol contributor: fullname: Reizis – volume: 4 start-page: 184 year: 1984 ident: 10.1016/j.jhep.2017.11.029_b0025 article-title: Cytomegalovirus hepatitis in normal and immune compromised hosts publication-title: Liver doi: 10.1111/j.1600-0676.1984.tb00926.x contributor: fullname: Ten Napel – volume: 1 start-page: 4 year: 2001 ident: 10.1016/j.jhep.2017.11.029_b0180 article-title: Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus publication-title: BMC Dev Biol doi: 10.1186/1471-213X-1-4 contributor: fullname: Srinivas – volume: 74 start-page: 11230 year: 2000 ident: 10.1016/j.jhep.2017.11.029_b0125 article-title: The vaccinia virus soluble alpha/beta interferon (IFN) receptor binds to the cell surface and protects cells from the antiviral effects of IFN publication-title: J Virol doi: 10.1128/JVI.74.23.11230-11239.2000 contributor: fullname: Alcami – volume: 32 start-page: 80 year: 2016 ident: 10.1016/j.jhep.2017.11.029_b0005 article-title: Liver failure due to acute viral hepatitis (A-E) publication-title: Visc Med doi: 10.1159/000444915 contributor: fullname: Manka – volume: 83 start-page: 1563 year: 2009 ident: 10.1016/j.jhep.2017.11.029_b0130 article-title: Vaccinia virus-mediated inhibition of type I interferon responses is a multifactorial process involving the soluble type I interferon receptor B18 and intracellular components publication-title: J Virol doi: 10.1128/JVI.01617-08 contributor: fullname: Waibler – year: 2011 ident: 10.1016/j.jhep.2017.11.029_b0205 article-title: Seven steps to stellate cells publication-title: J Vis Exp doi: 10.3791/2710 contributor: fullname: Maschmeyer – volume: 14 start-page: 996 year: 2013 ident: 10.1016/j.jhep.2017.11.029_b0055 article-title: Immune surveillance by the liver publication-title: Nat Immunol doi: 10.1038/ni.2691 contributor: fullname: Jenne – volume: 15 start-page: 87 year: 2015 ident: 10.1016/j.jhep.2017.11.029_b0095 article-title: Type I interferons in infectious disease publication-title: Nat Rev Immunol doi: 10.1038/nri3787 contributor: fullname: McNab – volume: 174 start-page: 1549 year: 2005 ident: 10.1016/j.jhep.2017.11.029_b0105 article-title: Monocyte chemoattractant protein-1 and CCR2 interactions are required for IFN-/-induced inflammatory responses and antiviral defense in liver publication-title: J Immunol doi: 10.4049/jimmunol.174.3.1549 contributor: fullname: Hokeness – volume: 85 start-page: 10346 year: 2011 ident: 10.1016/j.jhep.2017.11.029_b0200 article-title: Virus progeny of murine cytomegalovirus bacterial artificial chromosome pSM3fr show reduced growth in salivary Glands due to a fixed mutation of MCK-2 publication-title: J Virol doi: 10.1128/JVI.00545-11 contributor: fullname: Jordan – volume: 40 start-page: 2769 year: 2010 ident: 10.1016/j.jhep.2017.11.029_b0150 article-title: Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion publication-title: Eur J Immunol doi: 10.1002/eji.201040453 contributor: fullname: Frenz – volume: 177 start-page: 687 year: 2014 ident: 10.1016/j.jhep.2017.11.029_b0020 article-title: Type III interferons are expressed by Coxsackievirus-infected human primary hepatocytes and regulate hepatocyte permissiveness to infection publication-title: Clin Exp Immunol doi: 10.1111/cei.12368 contributor: fullname: Lind – volume: 42 start-page: 145 year: 2015 ident: 10.1016/j.jhep.2017.11.029_b0240 article-title: Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection publication-title: Immunity doi: 10.1016/j.immuni.2014.12.020 contributor: fullname: Bleriot – volume: 91 start-page: 70 year: 2012 ident: 10.1016/j.jhep.2017.11.029_b0145 article-title: The role of cell types in cytomegalovirus infection in vivo publication-title: Eur J Cell Biol doi: 10.1016/j.ejcb.2011.02.002 contributor: fullname: Sacher – volume: 2 start-page: 549 year: 2015 ident: 10.1016/j.jhep.2017.11.029_b0090 article-title: No love lost between viruses and interferons publication-title: Annu Rev Virol doi: 10.1146/annurev-virology-100114-055249 contributor: fullname: Fensterl – volume: 92 start-page: 723 year: 2012 ident: 10.1016/j.jhep.2017.11.029_b0050 article-title: Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages publication-title: J Leukoc Biol doi: 10.1189/jlb.1111566 contributor: fullname: Movita – volume: 3 start-page: 125 year: 2015 ident: 10.1016/j.jhep.2017.11.029_b0010 article-title: Dengue and its effects on liver publication-title: World J Clin Cases doi: 10.12998/wjcc.v3.i2.125 contributor: fullname: Samanta – volume: 88 start-page: 7578 year: 2014 ident: 10.1016/j.jhep.2017.11.029_b0120 article-title: IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus publication-title: J Virol doi: 10.1128/JVI.03117-13 contributor: fullname: Li – volume: 62 start-page: 279 year: 2015 ident: 10.1016/j.jhep.2017.11.029_b0045 article-title: Liver inflammation abrogates immunological tolerance induced by Kupffer cells publication-title: Hepatology doi: 10.1002/hep.27793 contributor: fullname: Heymann – volume: 52 start-page: 25 year: 2010 ident: 10.1016/j.jhep.2017.11.029_b0065 article-title: Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice publication-title: Hepatology doi: 10.1002/hep.23640 contributor: fullname: Lang – volume: 29 start-page: 609 year: 2009 ident: 10.1016/j.jhep.2017.11.029_b0135 article-title: Multifaceted evasion of the interferon response by cytomegalovirus publication-title: J Interferon Cytokine Res doi: 10.1089/jir.2009.0064 contributor: fullname: Marshall – volume: 5 start-page: 47 year: 2008 ident: 10.1016/j.jhep.2017.11.029_b0235 article-title: Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review publication-title: Virol J doi: 10.1186/1743-422X-5-47 contributor: fullname: Rafailidis – volume: 131 start-page: 1531 year: 1983 ident: 10.1016/j.jhep.2017.11.029_b0140 article-title: Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo publication-title: J Immunol doi: 10.4049/jimmunol.131.3.1531 contributor: fullname: Bukowski – volume: 28 start-page: 675 year: 2008 ident: 10.1016/j.jhep.2017.11.029_b0195 article-title: Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system publication-title: Immunity doi: 10.1016/j.immuni.2008.03.011 contributor: fullname: Prinz – volume: 183 start-page: 3229 year: 2009 ident: 10.1016/j.jhep.2017.11.029_b0160 article-title: Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo publication-title: J Immunol doi: 10.4049/jimmunol.0804277 contributor: fullname: Lienenklaus – volume: 269 start-page: 1427 year: 1995 ident: 10.1016/j.jhep.2017.11.029_b0175 article-title: Inducible gene targeting in mice publication-title: Science doi: 10.1126/science.7660125 contributor: fullname: Kuhn – volume: 274 start-page: 305 year: 1999 ident: 10.1016/j.jhep.2017.11.029_b0185 article-title: Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase publication-title: J Biol Chem doi: 10.1074/jbc.274.1.305 contributor: fullname: Postic – volume: 44 start-page: 879 year: 2006 ident: 10.1016/j.jhep.2017.11.029_b0015 article-title: The role of Epstein-Barr virus in acute and chronic hepatitis publication-title: J Hepatol doi: 10.1016/j.jhep.2006.02.006 contributor: fullname: Drebber – volume: 7 start-page: 10321 year: 2016 ident: 10.1016/j.jhep.2017.11.029_b0210 article-title: Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells publication-title: Nat Commun doi: 10.1038/ncomms10321 contributor: fullname: Scott – volume: 3 start-page: 67 year: 2008 ident: 10.1016/j.jhep.2017.11.029_b0220 article-title: Lymphotoxin-mediated crosstalk between B cells and splenic stroma promotes the initial type I interferon response to cytomegalovirus publication-title: Cell Host Microbe doi: 10.1016/j.chom.2007.12.008 contributor: fullname: Schneider – volume: 89 start-page: 4809 year: 2015 ident: 10.1016/j.jhep.2017.11.029_b0075 article-title: Inflammatory monocytes recruited to the liver within 24 h after virus-induced inflammation resemble Kupffer cells but are functionally distinct publication-title: J Virol doi: 10.1128/JVI.03733-14 contributor: fullname: Movita – volume: 212 start-page: 447 year: 2015 ident: 10.1016/j.jhep.2017.11.029_b0085 article-title: A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury publication-title: J Exp Med doi: 10.1084/jem.20141539 contributor: fullname: Dal-Secco – volume: 20 start-page: 4106 year: 2000 ident: 10.1016/j.jhep.2017.11.029_b0170 article-title: Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion publication-title: Mol Cell Biol doi: 10.1128/MCB.20.11.4106-4114.2000 contributor: fullname: Jung – volume: 109 start-page: E3186 year: 2012 ident: 10.1016/j.jhep.2017.11.029_b0080 article-title: Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1119964109 contributor: fullname: Ramachandran – volume: 182 start-page: 1099 year: 2009 ident: 10.1016/j.jhep.2017.11.029_b0100 article-title: Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection publication-title: J Immunol doi: 10.4049/jimmunol.182.2.1099 contributor: fullname: Cervantes-Barragan – volume: 38 start-page: 79 year: 2013 ident: 10.1016/j.jhep.2017.11.029_b0030 article-title: Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis publication-title: Immunity doi: 10.1016/j.immuni.2012.12.001 contributor: fullname: Yona – volume: 65 start-page: 758 year: 2016 ident: 10.1016/j.jhep.2017.11.029_b0215 article-title: Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions publication-title: J Hepatol doi: 10.1016/j.jhep.2016.05.037 contributor: fullname: Beattie – volume: 33 start-page: 57 year: 2013 ident: 10.1016/j.jhep.2017.11.029_b0060 article-title: Role of scavenger receptors in the pathophysiology of chronic liver diseases publication-title: Crit Rev Immunol contributor: fullname: Armengol – volume: 88 start-page: 13638 year: 2014 ident: 10.1016/j.jhep.2017.11.029_b0225 article-title: M27 expressed by cytomegalovirus counteracts effective type I interferon induction of myeloid cells but not of plasmacytoid dendritic cells publication-title: J Virol doi: 10.1128/JVI.00216-14 contributor: fullname: Döring – volume: 264 start-page: 1918 year: 1994 ident: 10.1016/j.jhep.2017.11.029_b0155 article-title: Functional role of type I and type II interferons in antiviral defense publication-title: Science doi: 10.1126/science.8009221 contributor: fullname: Muller – volume: 94 start-page: 2367 year: 2013 ident: 10.1016/j.jhep.2017.11.029_b0230 article-title: Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity publication-title: J Gen Virol doi: 10.1099/vir.0.055921-0 contributor: fullname: Smith – volume: 84 start-page: 8626 year: 2010 ident: 10.1016/j.jhep.2017.11.029_b0165 article-title: Temporal and spatial resolution of type I and III interferon responses in vivo publication-title: J Virol doi: 10.1128/JVI.00303-10 contributor: fullname: Pulverer – volume: 17 start-page: 451 year: 2017 ident: 10.1016/j.jhep.2017.11.029_b0245 article-title: Does niche competition determine the origin of tissue-resident macrophages? publication-title: Nat Rev Immunol doi: 10.1038/nri.2017.42 contributor: fullname: Guilliams – volume: 518 start-page: 547 year: 2015 ident: 10.1016/j.jhep.2017.11.029_b0035 article-title: Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors publication-title: Nature doi: 10.1038/nature13989 contributor: fullname: Gomez Perdiguero – volume: 49 start-page: 519 year: 1999 ident: 10.1016/j.jhep.2017.11.029_b0070 article-title: The role of Kupffer cells and regulation of neutrophil migration into the liver by macrophage inflammatory protein-2 in primary listeriosis in mice publication-title: Pathol Int doi: 10.1046/j.1440-1827.1999.00910.x contributor: fullname: Ebe – volume: 59 start-page: 1555 year: 2014 ident: 10.1016/j.jhep.2017.11.029_b0110 article-title: Protection against RNA-induced liver damage by myeloid cells requires type I interferon and IL-1 receptor antagonist in mice publication-title: Hepatology doi: 10.1002/hep.26915 contributor: fullname: Conrad – volume: 108 start-page: 3253 year: 2006 ident: 10.1016/j.jhep.2017.11.029_b0190 article-title: Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia publication-title: Blood doi: 10.1182/blood-2006-06-027599 contributor: fullname: Kamphuis – volume: 13 start-page: 316 year: 2016 ident: 10.1016/j.jhep.2017.11.029_b0040 article-title: Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies publication-title: Cell Mol Immunol doi: 10.1038/cmi.2015.104 contributor: fullname: Ju – volume: 43 start-page: 974 year: 2015 ident: 10.1016/j.jhep.2017.11.029_b0115 article-title: Superoxide dismutase 1 protects hepatocytes from type i interferon-driven oxidative damage publication-title: Immunity doi: 10.1016/j.immuni.2015.10.013 contributor: fullname: Bhattacharya |
| SSID | ssj0003094 |
| Score | 2.4931757 |
| Snippet | [Display omitted]
•During acute viral hepatitis local IFN-I responses modulate liver inflammation.•IFNAR triggering of Kupffer cells protects against liver... Virus-induced fulminant hepatitis is a major cause of acute liver failure. During acute viral hepatitis the impact of type I interferon (IFN-I) on myeloid... Background & Aim Virus-induced fulminant hepatitis is a major cause of acute liver failure. During acute viral hepatitis the impact of type I interferon... BACKGROUND & AIMVirus-induced fulminant hepatitis is a major cause of acute liver failure. During acute viral hepatitis the impact of type I interferon (IFN-I)... |
| SourceID | proquest crossref pubmed elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 682 |
| SubjectTerms | Acute Disease Animals Bone marrow CX3CR1 protein Cytomegalovirus DNA vaccines DNA virus infection DNA viruses Hepatitis Hepatitis, Viral, Animal - etiology Hepatitis, Viral, Animal - physiopathology Hepatocytes Hepatology Infections Innate immunity Interferon Kupffer cells Kupffer Cells - physiology Liver Liver diseases Liver inflammation Mice Mice, Inbred C57BL Monocyte infiltration Monocytes Myeloid cells Receptor, Interferon alpha-beta - physiology Signal Transduction - physiology Vaccinia - physiopathology β-Interferon |
| Title | Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis |
| URI | https://dx.doi.org/10.1016/j.jhep.2017.11.029 https://www.ncbi.nlm.nih.gov/pubmed/29274730 https://www.proquest.com/docview/2076372028 https://search.proquest.com/docview/1980102680 |
| Volume | 68 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lj9MwELa6i4S4IN4UFmQkblGqJk5i58ijq10hEKJFWnGJ4tiBVmxSJc1h-fXMxI7bsioCJC5RZaupPfPZHk-_mSHkJVisIU-V8kuhtB_xMvRTAetR8TKQQZFH0xx9umdz_uFCvJ1Fs9FoKKazbfuvmoY20DVGzv6Ftt1LoQE-g87hCVqH55_pHX2q530aiKbUTY3hKkhdqRsPuRp5H36OqSGvWu9dt8byKB567_HfAziBlu23nh4whC8WyCMou--GMeMhJRiDJ5GHvVm2B0zbvn_PX_-6bkxwCbI34HpeudPgtNHVD0NV0nD1d-3zNQa_N0MMt2tf6K-bS31lej4uc3__jdaBEYgd3kvvVbsWWWMcnYnwRWjK-0y02ZwTjIJPTKKsYfdOxA5Ko52tODFFjeypnpiipNcODOO7WE1WIBkk-vEJ5nS1Tpj9RNxzHBMOKeBghXJ2cURuAM4Z7q5f4k_u_GfT1GaUNzOwoVqGVfjr7xwyhw5dd3qzZ3GH3LZKpa8M0O6Ska7ukZvvLSPjPrlEvNFzusUbHfBGHd6owRu1eKOIN7qHN2rwRnu8UYc32uONOrw9IJ9PZ4s3Z74t4eEXURpt_DTMMXtSqEstYbfnsFILLmQqwLItFQ-KKGZScq6kZoqFMpGqgBuBFIzplBWCPSTHVV3px4SCsVVMpVBxHoHlFSWp0oyjeR-DEVYyPibeIMlsbTK1ZAOFcZWh3DOUO1x5M5D7mMSDsDNraxobMgNk_PZ7J4NmMrvqW-iHUxrmFooxeeG6YZ9GceaVrrs2C2DOYMwnYjomj4xG3TDDFH1DbPrkHwf1lNzaLqwTcrxpOv2MHLWqe95D8yeHBcLj |
| link.rule.ids | 315,782,786,27933,27934 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Type+I+interferon+receptor+signaling+delays+Kupffer+cell+replenishment+during+acute+fulminant+viral+hepatitis&rft.jtitle=Journal+of+hepatology&rft.au=Borst%2C+Katharina&rft.au=Frenz%2C+Theresa&rft.au=Spanier%2C+Julia&rft.au=Tegtmeyer%2C+Pia-Katharina&rft.date=2018-04-01&rft.pub=Elsevier+B.V&rft.issn=0168-8278&rft.eissn=1600-0641&rft.volume=68&rft.issue=4&rft.spage=682&rft.epage=690&rft_id=info:doi/10.1016%2Fj.jhep.2017.11.029&rft.externalDocID=S016882781732473X |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0168-8278&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0168-8278&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0168-8278&client=summon |