Ventricular Arrhythmias Following Ibrutinib Initiation for Lymphoid Malignancies

• Published in: Journal of the American College of Cardiology Vol. 72; no. 6; pp. 697 - 698
• Main Authors: Guha, Avirup, Derbala, Mohamed H., Zhao, Qiuhong, Wiczer, Tracy E., Woyach, Jennifer A., Byrd, John C., Awan, Farrukh T., Addison, Daniel
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07-08-2018; Elsevier Limited
• Subjects: Agammaglobulinaemia Tyrosine Kinase - antagonists & inhibitors; Aged; Arrhythmia; Cardiac arrhythmia; Cardiology; Cardiovascular disease; Cohort Studies; Diabetes; Female; Follow-Up Studies; Humans; Lymphoma - diagnosis; Lymphoma - drug therapy; Lymphoma - epidemiology; Male; Middle Aged; Protein Kinase Inhibitors - adverse effects; Pyrazoles - adverse effects; Pyrimidines - adverse effects; Survival analysis; Ventricle; Ventricular Fibrillation - chemically induced; Ventricular Fibrillation - diagnosis; Ventricular Fibrillation - epidemiology; United States > US
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2018.06.002

VA-associated symptoms included chest pain, palpitations, dizziness, syncope, heart failure (HF) symptoms, and sudden cardiac death. [...]subgroup analysis among patients without baseline coronary artery disease (CAD) and/or left ventricular ejection fraction <50% (HF with reduced ejection fraction) was performed. In a multivariable model, only previous atrial fibrillation was associated with arrhythmic events. [...]among those without baseline CAD and HF with reduced ejection fraction, 6 patients had an incident VA event, corresponding to an estimated 100,000 person-year incidence rate of 596 (Figure 1).