Endogenous Adenosine May Be Related to Left Ventricular Dysfunction, Dilation, and Wall Thinning in Patients With Heart Disease

• Published in: Circulation Journal Vol. 82; no. 5; pp. 1319 - 1326
• Main Authors: Kinomura, Yujiro, Tanaka, Toshiki, Aoyama, Takuma, Hatasa, Masanori, Minatoguchi, Shingo, Iwasa, Masamitsu, Yamada, Yoshihisa, Nawa, Takahide, Kanamori, Hiromitsu, Kawasaki, Masanori, Esaka, Yukihiro, Uno, Bunji, Nishigaki, Kazuhiko, Minatoguchi, Shinya
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 25-04-2018
• Subjects: Adenosine - blood; Aged; Aged, 80 and over; Cardiomyopathy, Dilated - blood; Cardiomyopathy, Dilated - pathology; Cardiomyopathy, Dilated - physiopathology; Female; Humans; Interventricular septum thickness; LV dysfunction; LV end-diastolic dimension; LV wall thickness; Male; Middle Aged; Myocardium - metabolism; Myocardium - pathology; Plasma adenosine concentration; Ventricular Dysfunction, Left - blood; Ventricular Dysfunction, Left - pathology; Ventricular Dysfunction, Left - physiopathology; Plasma adenosine concentration; LV dysfunction; LV wall thickness; LV end-diastolic dimension; Interventricular septum thickness
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.CJ-17-0972

Background:The role of endogenous adenosine in cardiac patients is still unclear, so we investigated the relationship between the plasma adenosine concentration and left ventricular (LV) function, LV dilation and LV wall thinning in cardiac patients.Methods and Results:In 97 cardiac patients, with angina pectoris, old myocardial infarction, dilated or hypertrophic cardiomyopathy, and valvular heart disease, plasma adenosine concentrations were measured using the LC-MS/MS system, and the LV function, LV end-diastolic dimension (LVDd), LV posterior wall thickness (LVPWth), and interventricular septum thickness (IVSth) were assessed by echocardiography. The plasma adenosine concentration was significantly higher in patients with a LV ejection fraction (EF), an indicator of the LV systolic function, <47% compared with those with LVEF ≥47% (P=0.027). There was no difference between the plasma adenosine concentration and E/e’, an indicator of LV diastolic function. The plasma adenosine concentration was significantly higher in patients with LVDd ≥50 mm than in those with LVDd <50 mm (P=0.030). The plasma adenosine concentration was inversely correlated with IVSth (P=0.003) and LVPWth (P=0.0007). The plasma adenosine concentration was significantly higher in patients with IVSth <8 mm than in those with IVSth ≥8 mm (P=0.015), and was significantly higher in patients with LVPWth <8 mm than in those with LVPWth ≥8 mm (P=0.020).Conclusions:Endogenous adenosine may be related to LV dysfunction, dilation, and wall thinning in cardiac patients.