Increased Plasma Adenosine Concentration in the Subacute Phase May Contribute to Attenuation of Left Ventricular Dilation in the Chronic Phase in Patients With Acute Myocardial Infarction

• Published in: Circulation Journal Vol. 83; no. 4; pp. 783 - 792
• Main Authors: Hatasa, Masanori, Tanaka, Toshiki, Minatoguchi, Shingo, Yamada, Yoshihisa, Kanamori, Hiromitsu, Kawasaki, Masanori, Nishigaki, Kazuhiko, Esaka, Yukihiro, Uno, Bunji, Minatoguchi, Shinya
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 25-03-2019
• Subjects: Acute myocardial infarction; Adenosine - blood; Aged; Case-Control Studies; Dilatation; Female; Humans; Left ventricular dilation; Left ventricular ejection fraction; Male; Middle Aged; Myocardial Infarction - physiopathology; Plasma adenosine concentration; Stroke Volume; Time Factors; Ventricular Function, Left - drug effects; Ventricular Remodeling - drug effects; Plasma adenosine concentration; Left ventricular dilation; Acute myocardial infarction; Left ventricular ejection fraction
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.CJ-18-1107

Background: Changes in the plasma adenosine concentration and the effects on left ventricular (LV) function and remodeling in patients with acute myocardial infarction (AMI) remain unclear. Methods and Results: In 58 patients with AMI and 14 subjects without cardiac disease (controls), we measured the plasma adenosine concentration by LC-MS/MS. Blood samples were taken from the antecubital vein on days 0, 1, 7, and 14 after AMI, and from the controls on admission. Cardiac echocardiography was performed in the acute (within 7 days) and chronic (6 months) phases of AMI. There were no significant differences in the plasma adenosine concentrations among days 0 (211.5±150.2 nmol/L), 1 (192.7±141.3 nmol/L), 7 (218.8±154.1 nmol/L), and the controls (136.0±50.9 nmol/L). The plasma adenosine concentration increased significantly on day 14 (321.1±195.4 nmol/L) after AMI as compared with days 0, 1 and 7. AMI patients with a greater increase in the plasma adenosine concentration in the subacute phase showed an attenuation of LV dilation in the chronic phase. The plasma adenosine concentration in the acute phase did not affect the LV ejection fraction in the chronic phase. Conclusions: The plasma adenosine concentration significantly increased 14 days after AMI, which may contribute to attenuation of LV dilation in the chronic phase.