Peroxisome proliferator-activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages

Lipoprotein lipase (LPL) acts independently of its function as triglyceride hydrolase by stimulating macrophage binding and uptake of native, oxidized and glycated LDL. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors expressed in monocyte/macrophages, where they control cho...

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Bibliographic Details
Published in:	FEBS letters Vol. 512; no. 1; pp. 85 - 90
Main Authors:	Gbaguidi, F.G, Chinetti, G, Milosavljevic, D, Teissier, E, Chapman, J, Olivecrona, G, Fruchart, J.C, Griglio, S, Fruchart-Najib, J, Staels, B
Format:	Journal Article
Language:	English
Published:	England Elsevier B.V 13-02-2002
Subjects:	Atherosclerosis Biological Transport Cell Differentiation Diabetes Humans Lipoprotein Lipase - metabolism Lipoprotein metabolism Lipoproteins, LDL - metabolism Macrophages - cytology Macrophages - metabolism Monocytes - cytology Monocytes - metabolism Receptors, Cytoplasmic and Nuclear - agonists Transcription Factors - agonists Vascular wall Diabetes Lipoprotein metabolism Vascular wall Atherosclerosis
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