Hypervirulence of a Rough Variant of the Mycobacterium abscessus Type Strain

We isolated a rough variant of Mycobacterium abscessus CIP 104536T during experimental infection of mice. We show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for C57BL/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by...

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Bibliographic Details
Published in:	Infection and Immunity Vol. 75; no. 2; pp. 1055 - 1058
Main Authors:	Catherinot, E, Clarissou, J, Etienne, G, Ripoll, F, Emile, J.-F, Daffé, M, Perronne, C, Soudais, C, Gaillard, J.-L, Rottman, M
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-02-2007
Subjects:	Animals Bacterial Infections Biological and medical sciences Disease Models, Animal Fundamental and applied biological sciences. Psychology Glycolipids - biosynthesis Glycopeptides - biosynthesis Macrophages - immunology Mice Mice, Inbred C57BL Microbiology Mutation Mycobacterium abscessus Mycobacterium chelonae - immunology Mycobacterium chelonae - pathogenicity Mycobacterium chelonae - physiology Mycobacterium Infections, Nontuberculous - immunology Mycobacterium Infections, Nontuberculous - microbiology Survival Analysis Tumor Necrosis Factor-alpha - biosynthesis Virulence Microbiology Mycobacteriales Mycobacteriaceae Bacteria Actinomycetes Immunity Mycobacterium abscessus Strain
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Summary:	We isolated a rough variant of Mycobacterium abscessus CIP 104536T during experimental infection of mice. We show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for C57BL/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by murine monocyte-derived macrophages.
Bibliography:	http://iai.asm.org/ ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Editor: J. L. Flynn Corresponding author. Mailing address: Laboratoire de Microbiologie, Hôpital Raymond Poincaré, 104 Bd Raymond Poincaré, 92380 Garches, France. Phone: 33.1.47.10.46.22. Fax: 33.1.47.10.79.49. E-mail: martin.rottman@rpc.aphp.fr.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.00835-06