Antiproliferative and Antimicrobial Activities of Selected Bryophytes
One-hundred and sixty-eight aqueous and organic extracts of 42 selected bryophyte species were screened in vitro for antiproliferative activity on a panel of human gynecological cancer cell lines containing HeLa (cervix epithelial adenocarcinoma), A2780 (ovarian carcinoma), and T47D (invasive ductal...
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| Published in: | Molecules (Basel, Switzerland) Vol. 23; no. 7; p. 1520 |
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| Abstract | One-hundred and sixty-eight aqueous and organic extracts of 42 selected bryophyte species were screened in vitro for antiproliferative activity on a panel of human gynecological cancer cell lines containing HeLa (cervix epithelial adenocarcinoma), A2780 (ovarian carcinoma), and T47D (invasive ductal breast carcinoma) cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and for antibacterial activity on 11 strains using the disc-diffusion method. A total of 99 extracts derived from 41 species exerted ≥25% inhibition of proliferation of at least one of the cancer cell lines at 10 μg/mL. In the cases of
,
,
,
,
, and
, more than one extract was active in the antiproliferative assay, whereas the highest activity was observed in the case of
. From the tested families, Brachytheciaceae and Amblystegiaceae provided the highest number of antiproliferative extracts. Only 19 samples of 15 taxa showed moderate antibacterial activity, including the most active
, being active on 8 tested strains. Methicillin-resistant
(MRSA) and
were the most susceptible to the assayed species. This is the first report on the bioactivities of these 14 species. |
|---|---|
| AbstractList | One-hundred and sixty-eight aqueous and organic extracts of 42 selected bryophyte species were screened in vitro for antiproliferative activity on a panel of human gynecological cancer cell lines containing HeLa (cervix epithelial adenocarcinoma), A2780 (ovarian carcinoma), and T47D (invasive ductal breast carcinoma) cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and for antibacterial activity on 11 strains using the disc-diffusion method. A total of 99 extracts derived from 41 species exerted ≥25% inhibition of proliferation of at least one of the cancer cell lines at 10 μg/mL. In the cases of
,
,
,
,
, and
, more than one extract was active in the antiproliferative assay, whereas the highest activity was observed in the case of
. From the tested families, Brachytheciaceae and Amblystegiaceae provided the highest number of antiproliferative extracts. Only 19 samples of 15 taxa showed moderate antibacterial activity, including the most active
, being active on 8 tested strains. Methicillin-resistant
(MRSA) and
were the most susceptible to the assayed species. This is the first report on the bioactivities of these 14 species. One-hundred and sixty-eight aqueous and organic extracts of 42 selected bryophyte species were screened in vitro for antiproliferative activity on a panel of human gynecological cancer cell lines containing HeLa (cervix epithelial adenocarcinoma), A2780 (ovarian carcinoma), and T47D (invasive ductal breast carcinoma) cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and for antibacterial activity on 11 strains using the disc-diffusion method. A total of 99 extracts derived from 41 species exerted ≥25% inhibition of proliferation of at least one of the cancer cell lines at 10 μg/mL. In the cases of Brachythecium rutabulum, Encalypta streptocarpa, Climacium dendroides, Neckera besseri, Pleurozium schreberi, and Pseudoleskeella nervosa, more than one extract was active in the antiproliferative assay, whereas the highest activity was observed in the case of Paraleucobryum longifolium. From the tested families, Brachytheciaceae and Amblystegiaceae provided the highest number of antiproliferative extracts. Only 19 samples of 15 taxa showed moderate antibacterial activity, including the most active Plagiomnium cuspidatum, being active on 8 tested strains. Methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus were the most susceptible to the assayed species. This is the first report on the bioactivities of these 14 species. One-hundred and sixty-eight aqueous and organic extracts of 42 selected bryophyte species were screened in vitro for antiproliferative activity on a panel of human gynecological cancer cell lines containing HeLa (cervix epithelial adenocarcinoma), A2780 (ovarian carcinoma), and T47D (invasive ductal breast carcinoma) cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and for antibacterial activity on 11 strains using the disc-diffusion method. A total of 99 extracts derived from 41 species exerted ≥25% inhibition of proliferation of at least one of the cancer cell lines at 10 μg/mL. In the cases of Brachythecium rutabulum , Encalypta streptocarpa , Climacium dendroides , Neckera besseri , Pleurozium schreberi , and Pseudoleskeella nervosa , more than one extract was active in the antiproliferative assay, whereas the highest activity was observed in the case of Paraleucobryum longifolium . From the tested families, Brachytheciaceae and Amblystegiaceae provided the highest number of antiproliferative extracts. Only 19 samples of 15 taxa showed moderate antibacterial activity, including the most active Plagiomnium cuspidatum , being active on 8 tested strains. Methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus were the most susceptible to the assayed species. This is the first report on the bioactivities of these 14 species. |
| Author | Csupor-Löffler, Boglárka Csorba, Attila Zupkó, István Urbán, Edit Vollár, Martin Gyovai, András Vecsernyés, Anikó Csupor, Dezső Szűcs, Péter Bérdi, Péter Liktor-Busa, Erika Marschall, Marianna |
| AuthorAffiliation | 3 Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Hungary; gyovaiandras@gmail.com (A.G.); zupko@pharm.u-szeged.hu (I.Z.); berdi.peter@pharm.u-szeged.hu (P.B.) 2 Interdisciplinary Centre for Natural Products, University of Szeged, H-6720 Szeged, Hungary 4 Department of Botany and Plant Physiology, Institute of Biology, Eszterházy Károly University, H-3300 Eger, Hungary; szucs.peter@uni-eszterhazy.hu (P.S.); marschall.marianna@uni-eszterhazy.hu (M.M.) 1 Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Hungary; vollar@pharmacognosy.hu (M.V.); csupor.boglarka@pharmacognosy.hu (B.C.-L.); veasaat.sze@gmail.com (A.V.); csorba@pharmacognosy.hu (A.C.); erikal@email.arizona.edu (E.L.-B.) 5 Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary; urban.edit@med.u-szeged.hu |
| AuthorAffiliation_xml | – name: 4 Department of Botany and Plant Physiology, Institute of Biology, Eszterházy Károly University, H-3300 Eger, Hungary; szucs.peter@uni-eszterhazy.hu (P.S.); marschall.marianna@uni-eszterhazy.hu (M.M.) – name: 2 Interdisciplinary Centre for Natural Products, University of Szeged, H-6720 Szeged, Hungary – name: 3 Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Hungary; gyovaiandras@gmail.com (A.G.); zupko@pharm.u-szeged.hu (I.Z.); berdi.peter@pharm.u-szeged.hu (P.B.) – name: 1 Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Hungary; vollar@pharmacognosy.hu (M.V.); csupor.boglarka@pharmacognosy.hu (B.C.-L.); veasaat.sze@gmail.com (A.V.); csorba@pharmacognosy.hu (A.C.); erikal@email.arizona.edu (E.L.-B.) – name: 5 Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary; urban.edit@med.u-szeged.hu |
| Author_xml | – sequence: 1 givenname: Martin surname: Vollár fullname: Vollár, Martin email: vollar@pharmacognosy.hu, vollar@pharmacognosy.hu organization: Interdisciplinary Centre for Natural Products, University of Szeged, H-6720 Szeged, Hungary. vollar@pharmacognosy.hu – sequence: 2 givenname: András surname: Gyovai fullname: Gyovai, András email: gyovaiandras@gmail.com organization: Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Hungary. gyovaiandras@gmail.com – sequence: 3 givenname: Péter surname: Szűcs fullname: Szűcs, Péter email: szucs.peter@uni-eszterhazy.hu organization: Department of Botany and Plant Physiology, Institute of Biology, Eszterházy Károly University, H-3300 Eger, Hungary. szucs.peter@uni-eszterhazy.hu – sequence: 4 givenname: István orcidid: 0000-0003-3243-5300 surname: Zupkó fullname: Zupkó, István email: zupko@pharm.u-szeged.hu organization: Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Hungary. zupko@pharm.u-szeged.hu – sequence: 5 givenname: Marianna surname: Marschall fullname: Marschall, Marianna email: marschall.marianna@uni-eszterhazy.hu organization: Department of Botany and Plant Physiology, Institute of Biology, Eszterházy Károly University, H-3300 Eger, Hungary. marschall.marianna@uni-eszterhazy.hu – sequence: 6 givenname: Boglárka surname: Csupor-Löffler fullname: Csupor-Löffler, Boglárka email: csupor.boglarka@pharmacognosy.hu, csupor.boglarka@pharmacognosy.hu organization: Interdisciplinary Centre for Natural Products, University of Szeged, H-6720 Szeged, Hungary. csupor.boglarka@pharmacognosy.hu – sequence: 7 givenname: Péter surname: Bérdi fullname: Bérdi, Péter email: berdi.peter@pharm.u-szeged.hu organization: Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Hungary. berdi.peter@pharm.u-szeged.hu – sequence: 8 givenname: Anikó surname: Vecsernyés fullname: Vecsernyés, Anikó email: veasaat.sze@gmail.com organization: Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Hungary. veasaat.sze@gmail.com – sequence: 9 givenname: Attila surname: Csorba fullname: Csorba, Attila email: csorba@pharmacognosy.hu organization: Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Hungary. csorba@pharmacognosy.hu – sequence: 10 givenname: Erika surname: Liktor-Busa fullname: Liktor-Busa, Erika email: erikal@email.arizona.edu organization: Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Hungary. erikal@email.arizona.edu – sequence: 11 givenname: Edit surname: Urbán fullname: Urbán, Edit email: urban.edit@med.u-szeged.hu organization: Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary. urban.edit@med.u-szeged.hu – sequence: 12 givenname: Dezső surname: Csupor fullname: Csupor, Dezső email: csupor.dezso@pharm.u-szeged.hu, csupor.dezso@pharm.u-szeged.hu organization: Interdisciplinary Centre for Natural Products, University of Szeged, H-6720 Szeged, Hungary. csupor.dezso@pharm.u-szeged.hu |
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| Copyright | 2018. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2018 by the authors. 2018 |
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| Keywords | antibacterial antiproliferative MTT assay bryophytes |
| Language | English |
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| Title | Antiproliferative and Antimicrobial Activities of Selected Bryophytes |
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