Antiproliferative and Antimicrobial Activities of Selected Bryophytes

• Published in: Molecules (Basel, Switzerland) Vol. 23; no. 7; p. 1520
• Main Authors: Vollár, Martin, Gyovai, András, Szűcs, Péter, Zupkó, István, Marschall, Marianna, Csupor-Löffler, Boglárka, Bérdi, Péter, Vecsernyés, Anikó, Csorba, Attila, Liktor-Busa, Erika, Urbán, Edit, Csupor, Dezső
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23-06-2018; MDPI
• Subjects: Adenocarcinoma; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; antibacterial; Antibacterial activity; Antimicrobial agents; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; antiproliferative; Antiproliferatives; Assaying; Bacillus subtilis - drug effects; Bacillus subtilis - growth & development; Biotechnology; Breast cancer; Breast carcinoma; Bryophyta - chemistry; Bryophytes; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Cervix; Drug resistance; Epithelial Cells - drug effects; Epithelial Cells - pathology; Female; Humans; Inhibitory Concentration 50; Invasiveness; Methicillin; Methicillin-Resistant Staphylococcus aureus - drug effects; Methicillin-Resistant Staphylococcus aureus - growth & development; Microbial Sensitivity Tests; Moraxella catarrhalis - drug effects; Moraxella catarrhalis - growth & development; MTT assay; Ovarian carcinoma; Plant Extracts - chemistry; Plant Extracts - pharmacology; Staphylococcus aureus; Staphylococcus infections; Tumor cell lines; antibacterial; antiproliferative; MTT assay; bryophytes
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules23071520

One-hundred and sixty-eight aqueous and organic extracts of 42 selected bryophyte species were screened in vitro for antiproliferative activity on a panel of human gynecological cancer cell lines containing HeLa (cervix epithelial adenocarcinoma), A2780 (ovarian carcinoma), and T47D (invasive ductal breast carcinoma) cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and for antibacterial activity on 11 strains using the disc-diffusion method. A total of 99 extracts derived from 41 species exerted ≥25% inhibition of proliferation of at least one of the cancer cell lines at 10 μg/mL. In the cases of
,
,
,
,
, and
, more than one extract was active in the antiproliferative assay, whereas the highest activity was observed in the case of
. From the tested families, Brachytheciaceae and Amblystegiaceae provided the highest number of antiproliferative extracts. Only 19 samples of 15 taxa showed moderate antibacterial activity, including the most active
, being active on 8 tested strains. Methicillin-resistant
(MRSA) and
were the most susceptible to the assayed species. This is the first report on the bioactivities of these 14 species.