Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies

• Published in: Frontiers in neuroscience Vol. 15; p. 728092
• Main Authors: Lucio Boschen, Suelen, Trevathan, James, Hara, Seth A, Asp, Anders, Lujan, J Luis
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 12-11-2021; Frontiers Media S.A
• Subjects: Animal models; Animals; Carbon fibers; clinical neurochemistry; deep brain stimulation; Dopamine; Electrodes; fast scan cyclic voltammetry; intraoperative; Monkeys & apes; neurochemical signaling; neurophysiology; Neuroscience; Neurotransmitters; Patient safety; Patients; Safety; Voltammetry; intraoperative; neurophysiology; clinical neurochemistry; fast scan cyclic voltammetry; deep brain stimulation; neurochemical signaling
• ISSN: 1662-4548; 1662-453X; 1662-453X
• DOI: 10.3389/fnins.2021.728092

Fast Scan Cyclic Voltammetry (FSCV) has been used for decades as a neurochemical tool for
detection of phasic changes in electroactive neurotransmitters in animal models. Recently, multiple research groups have initiated human neurochemical studies using FSCV or demonstrated interest in bringing FSCV into clinical use. However, there remain technical challenges that limit clinical implementation of FSCV by creating barriers to appropriate scientific rigor and patient safety. In order to progress with clinical FSCV, these limitations must be first addressed through (1) appropriate pre-clinical studies to ensure accurate measurement of neurotransmitters and (2) the application of a risk management framework to assess patient safety. The intent of this work is to bring awareness of the current issues associated with FSCV to the scientific, engineering, and clinical communities and encourage them to seek solutions or alternatives that ensure data accuracy, rigor and reproducibility, and patient safety.