Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting

Transdermal drug delivery systems have been around for decades, and current technologies (e.g., patches, ointments, and creams) enhance the skin permeation of low molecular weight, lipophilic drugs that are efficacious at low doses. The objective of current transdermal drug delivery research is to d...

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Published in:	Molecules (Basel, Switzerland) Vol. 21; no. 12; p. 1719
Main Authors:	Palmer, Brian C, DeLouise, Lisa A
Format:	Journal Article Book Review
Language:	English
Published:	Switzerland MDPI AG 15-12-2016 MDPI
Subjects:	Administration, Cutaneous delivery Dermatitis, Atopic - drug therapy disease drug Drug Delivery Systems - methods Humans Hydrophobic and Hydrophilic Interactions Macromolecular Substances - pharmacokinetics nanocarrier nanoparticle Nanoparticles - therapeutic use Psoriasis - drug therapy Review skin Skin - metabolism Skin Absorption - drug effects Skin Absorption - physiology transdermal delivery disease transdermal skin nanocarrier nanoparticle drug
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Abstract	Transdermal drug delivery systems have been around for decades, and current technologies (e.g., patches, ointments, and creams) enhance the skin permeation of low molecular weight, lipophilic drugs that are efficacious at low doses. The objective of current transdermal drug delivery research is to discover ways to enhance skin penetration of larger, hydrophilic drugs and macromolecules for disease treatment and vaccination. Nanocarriers made of lipids, metals, or polymers have been successfully used to increase penetration of drugs or vaccines, control drug release, and target drugs to specific areas of skin in vivo. While more research is needed to identify the safety of nanocarriers, this technology has the potential to expand the use of transdermal routes of administration to a wide array of therapeutics. Here, we review the current state of nanoparticle skin delivery systems with special emphasis on targeting skin diseases.
AbstractList	Transdermal drug delivery systems have been around for decades, and current technologies (e.g., patches, ointments, and creams) enhance the skin permeation of low molecular weight, lipophilic drugs that are efficacious at low doses. The objective of current transdermal drug delivery research is to discover ways to enhance skin penetration of larger, hydrophilic drugs and macromolecules for disease treatment and vaccination. Nanocarriers made of lipids, metals, or polymers have been successfully used to increase penetration of drugs or vaccines, control drug release, and target drugs to specific areas of skin in vivo. While more research is needed to identify the safety of nanocarriers, this technology has the potential to expand the use of transdermal routes of administration to a wide array of therapeutics. Here, we review the current state of nanoparticle skin delivery systems with special emphasis on targeting skin diseases.
Author	DeLouise, Lisa A Palmer, Brian C
AuthorAffiliation	3 Department of Dermatology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA 1 Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA; Brian_Palmer@URMC.Rochester.edu 2 Department of Biomedical Engineering, School of Engineering and Applied Sciences, University of Rochester, Rochester, NY 14627, USA
AuthorAffiliation_xml	– name: 2 Department of Biomedical Engineering, School of Engineering and Applied Sciences, University of Rochester, Rochester, NY 14627, USA – name: 1 Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA; Brian_Palmer@URMC.Rochester.edu – name: 3 Department of Dermatology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
Author_xml	– sequence: 1 givenname: Brian C surname: Palmer fullname: Palmer, Brian C email: Brian_Palmer@URMC.Rochester.edu organization: Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. Brian_Palmer@URMC.Rochester.edu – sequence: 2 givenname: Lisa A surname: DeLouise fullname: DeLouise, Lisa A email: Lisa_DeLouise@urmc.rochester.edu, Lisa_DeLouise@urmc.rochester.edu, Lisa_DeLouise@urmc.rochester.edu organization: Department of Dermatology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. Lisa_DeLouise@urmc.rochester.edu
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Snippet	Transdermal drug delivery systems have been around for decades, and current technologies (e.g., patches, ointments, and creams) enhance the skin permeation of...
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SubjectTerms	Administration, Cutaneous delivery Dermatitis, Atopic - drug therapy disease drug Drug Delivery Systems - methods Humans Hydrophobic and Hydrophilic Interactions Macromolecular Substances - pharmacokinetics nanocarrier nanoparticle Nanoparticles - therapeutic use Psoriasis - drug therapy Review skin Skin - metabolism Skin Absorption - drug effects Skin Absorption - physiology transdermal
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Title	Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting
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