The Global Ascendency of OXA-48-Type Carbapenemases

• Published in: Clinical microbiology reviews Vol. 33; no. 1
• Main Authors: Pitout, Johann D D, Peirano, Gisele, Kock, Marleen M, Strydom, Kathy-Anne, Matsumura, Yasufumi
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 18-12-2019
• Subjects: Review; OXA-48-like; carbapenemases; Enterobacteriaceae
• ISSN: 0893-8512; 1098-6618
• DOI: 10.1128/cmr.00102-19

Surveillance studies have shown that OXA-48-like carbapenemases are the most common carbapenemases in
in certain regions of the world and are being introduced on a regular basis into regions of nonendemicity, where they are responsible for nosocomial outbreaks. OXA-48, OXA-181, OXA-232, OXA-204, OXA-162, and OXA-244, in that order, are the most common enzymes identified among the OXA-48-like carbapenemase group. OXA-48 is associated with different Tn
variants on IncL plasmids and is endemic in North Africa and the Middle East. OXA-162 and OXA-244 are derivatives of OXA-48 and are present in Europe. OXA-181 and OXA-232 are associated with IS
, Tn
on ColE2, and IncX3 types of plasmids and are endemic in the Indian subcontinent (e.g., India, Bangladesh, Pakistan, and Sri Lanka) and certain sub-Saharan African countries. Overall, clonal dissemination plays a minor role in the spread of OXA-48-like carbapenemases, but certain high-risk clones (e.g.,
sequence type 147 [ST147], ST307, ST15, and ST14 and
ST38 and ST410) have been associated with the global dispersion of OXA-48, OXA-181, OXA-232, and OXA-204. Chromosomal integration of
within Tn
occurred among
ST38 isolates, especially in the United Kingdom. The detection of
with OXA-48-like enzymes using phenotypic methods has improved recently but remains challenging for clinical laboratories in regions of nonendemicity. Identification of the specific type of OXA-48-like enzyme requires sequencing of the corresponding genes. Bacteria (especially
and
) with
,
, and
are emerging in different parts of the world and are most likely underreported due to problems with the laboratory detection of these enzymes. The medical community should be aware of the looming threat that is posed by bacteria with OXA-48-like carbapenemases.