Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins

Chromatin structure and function, and consequently cellular phenotype, is regulated in part by a network of chromatin-modifying enzymes that place post-translational modifications (PTMs) on histone tails. These marks serve as recruitment sites for other chromatin regulatory complexes that 'read...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 25; no. 4; p. 979
Main Authors:	Rectenwald, Justin M, Guduru, Shiva Krishna Reddy, Dang, Zhao, Collins, Leonard B, Liao, Yi-En, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Kaufmann, Kyle W, Hammond, Scott M, Kireev, Dmitri B, Frye, Stephen V, Pearce, Kenneth H
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 22-02-2020 MDPI
Subjects:	Binding sites Cellular structure Chromatin Chromatin - chemistry Chromatin - genetics Chromatin Assembly and Disassembly - genetics chromatin reader protein Communication Complex systems Computer applications Construction Deoxyribonucleic acid DNA DNA - chemistry DNA - genetics DNA methylation DNA probes dna-encoded libraries Domains Epigenome Gene Library Histones - genetics Humans Kinases Ligands Lysine Lysine - chemistry Lysine - genetics Optimization Organic chemistry Phenotypes Post-translation Protein Binding - genetics Protein Processing, Post-Translational - genetics Proteins Structure-function relationships Success target-class drug discovery target-class drug discovery DNA-Encoded Libraries chromatin reader protein
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