Anti-Inflammatory and Tau Phosphorylation-Inhibitory Effects of Eupatin

Alzheimer's disease (AD), which is among the most prevalent neurodegenerative diseases, manifests as increasing memory loss and cognitive decline. Tau phosphorylation and aggregation are strongly linked to neurodegeneration, as well as associated with chronic neuroinflammatory processes. The an...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 25; no. 23; p. 5652
Main Authors:	Chou, Ching-Hsuan, Hsu, Kai-Cheng, Lin, Tony Eight, Yang, Chia-Ron
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 30-11-2020 MDPI
Subjects:	Alzheimer's disease Animals Anti-Inflammatory Agents - pharmacology Apoptosis Cognitive ability Cyclin-dependent kinases Cytotoxicity Disease Drugs eupatin Flavonoids Flavonoids - pharmacology Glycogen Glycogen synthase kinase 3 glycogen synthase kinase 3β Glycogens Health services Hydrocarbons Hydrogen bonds Inflammation Interleukin 6 Kinases Lipopolysaccharides Macrophages Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Mice Microglia Microglia - drug effects Microglia - metabolism Microglia - pathology Molecular docking Molecular Docking Simulation Natural products Neurodegeneration neuroinflammation Neuroprotection Neuroprotective Agents - pharmacology Neurotoxicity Nitric oxide Nitric-oxide synthase Okadaic acid Oxidative stress Pathology Phosphoprotein phosphatase Phosphorylation Phytotherapy Plant Extracts - pharmacology Protein phosphatase Proteins tau Tau protein tau Proteins - antagonists & inhibitors Transfection Tumor necrosis factor-TNF Zingiberaceae - chemistry tau Alzheimer’s disease glycogen synthase kinase 3β eupatin neuroinflammation
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