Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 11; p. 3140
• Main Authors: Giordano, Rocco, Saii, Zeinab, Fredsgaard, Malthe, Hulkko, Laura Sini Sofia, Poulsen, Thomas Bouet Guldbæk, Thomsen, Mikkel Eggert, Henneberg, Nanna, Zucolotto, Silvana Maria, Arendt-Nielsen, Lars, Papenbrock, Jutta, Thomsen, Mette Hedegaard, Stensballe, Allan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24-05-2021; MDPI
• Subjects: Analgesics - pharmacology; Anti-Bacterial Agents - pharmacology; Anti-Inflammatory Agents - pharmacology; Antibiotics; Bioactive compounds; Biological activity; Biomedical materials; Cancer; Flowers & plants; Functional foods & nutraceuticals; Halophytes; Humans; hydroxycinnamic acid; Inflammation; Lipids; Metabolites; nutraceuticals; Pain; Pharmacology; Plant extracts; Plant Extracts - pharmacology; Plant species; Review; Salinity tolerance; Salt-Tolerant Plants - chemistry; Secondary metabolites; halophytes; secondary metabolites; inflammation; nutraceuticals; hydroxycinnamic acid
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules26113140

The pharmacological activities in bioactive plant extracts play an increasing role in sustainable resources for valorization and biomedical applications. Bioactive phytochemicals, including natural compounds, secondary metabolites and their derivatives, have attracted significant attention for use in both medicinal products and cosmetic products. Our review highlights the pharmacological mode-of-action and current biomedical applications of key bioactive compounds applied as anti-inflammatory, bactericidal with antibiotics effects, and pain relief purposes in controlled clinical studies or preclinical studies. In this systematic review, the availability of bioactive compounds from several salt-tolerant plant species, mainly focusing on the three promising species
,
and
, are summarized and discussed. All three of them have been widely used in natural folk medicines and are now in the focus for future nutraceutical and pharmacological applications.