Chrysin Induces Antidiabetic, Antidyslipidemic and Anti-Inflammatory Effects in Athymic Nude Diabetic Mice

• Published in: Molecules (Basel, Switzerland) Vol. 23; no. 1; p. 67
• Main Authors: Ramírez-Espinosa, Juan José, Saldaña-Ríos, Johann, García-Jiménez, Sara, Villalobos-Molina, Rafael, Ávila-Villarreal, Gabriela, Rodríguez-Ocampo, Angélica Nallelhy, Bernal-Fernández, Germán, Estrada-Soto, Samuel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28-12-2017; MDPI
• Subjects: Animals; Anti-Inflammatory Agents - therapeutic use; Antidiabetics; antidyslipidemic; Arteriosclerosis; Atherosclerosis; Blood Glucose; Blood levels; Cardiovascular diseases; chrysin; Complications; Cytokines; Cytokines - metabolism; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - drug therapy; Drugs; Flavonoids - administration & dosage; Flavonoids - therapeutic use; Flowers; Hypoglycemic Agents - therapeutic use; Hypolipidemic Agents - therapeutic use; IL-1β; Inflammation; Interleukin-1beta - metabolism; Male; Metformin; Metformin - therapeutic use; Mice; Mice, Nude; nude mice; Triglycerides; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-α; nude mice; antidyslipidemic; chrysin; inflammation; diabetes
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules23010067

Extensive knowledge of diabetes and its complications is helpful to find new drugs for proper treatment to stop degenerative changes derived from this disease. In this context, chrysin (5,7-dihydroxyflavone) is a natural product that occurs in a variety of flowers and fruits with anti-inflammatory and antidiabetic effects, among others. Thus, a diabetic model in athymic nude mice was developed and used to establish the ability of chrysin to decrease the secretion of pro-inflammatory cytokines. Also, it was determined the acute (50 mg/kg) and sub-acute (50 mg/kg/day/10 days) antidiabetic and antihyperlipidemic activities after the period of time treatment. Results indicate that chrysin has significant acute antihyperglycemic and antidiabetic effects in nude diabetic mice (
< 0.05). Moreover, triglyceride blood levels were reduced and IL-1β and TNF-α were diminished after 10 days' treatment compared with control group (
< 0.05). In conclusion, it was found that chrysin could produce similar effects as metformin, a drug used for the treatment of diabetes, since both test samples decreased glucose and triglycerides levels, they impaired the generation of pro-inflammatory cytokines involved in the development of diabetes and its consequences, such as atherosclerosis and other cardiovascular diseases.