A Novel Class of Cationic and Non-Peptidic Small Molecules as Hits for the Development of Antimicrobial Agents

Cationic and non-peptide small molecules containing a total of six positive charges arranged on one side and a long aliphatic tail on the other have been synthesized and tested against Gram-positive and Gram-negative bacteria. The positive charges have been contributed by two aminophenol residues. T...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 23; no. 7; p. 1513
Main Authors:	Jiménez, Aranza, García, Pablo, de la Puente, Sofia, Madrona, Andrés, Camarasa, María José, Pérez-Pérez, María-Jesús, Quintela, José-Carlos, García-Del Portillo, Francisco, San-Félix, Ana
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 22-06-2018 MDPI
Subjects:	Aliphatic compounds Aminophenol Aminophenols - chemistry Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology antibiotic resistance Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Antimicrobial Cationic Peptides - chemical synthesis Antimicrobial Cationic Peptides - pharmacology antimicrobial peptides Bacteria Cations Cell Line Cell Survival - drug effects Fibroblasts - cytology Fibroblasts - drug effects Gram-negative bacteria Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - growth & development Gram-positive bacteria Gram-Positive Bacteria - drug effects Gram-Positive Bacteria - growth & development HeLa Cells Humans Hydrophobic and Hydrophilic Interactions Hydrophobicity Microbial Sensitivity Tests Multidrug resistance Multidrug resistant organisms Small Molecule Libraries - chemical synthesis Small Molecule Libraries - pharmacology Species Specificity Static Electricity Strains (organisms) Structure-Activity Relationship antimicrobial agents antibiotic resistance antimicrobial peptides
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