Development of brain metastasis 5 years before the appearance of the primary lung cancer: “messenger metachronous metastasis”

• Published in: The Annals of thoracic surgery Vol. 75; no. 3; pp. 1016 - 1017
• Main Authors: Furák, József, Troján, Imre, Tiszlavicz, László, Micsik, Tamás, Puskás, László G
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-03-2003; Elsevier Science
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - pathology; Adenocarcinoma - secondary; Adenocarcinoma - surgery; Biological and medical sciences; Brain Neoplasms - genetics; Brain Neoplasms - pathology; Brain Neoplasms - secondary; Brain Neoplasms - surgery; Cerebellar Neoplasms - genetics; Cerebellar Neoplasms - pathology; Cerebellar Neoplasms - secondary; Cerebellar Neoplasms - surgery; Combined Modality Therapy; Female; Humans; Lung - pathology; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Medical sciences; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Nucleic Acid Hybridization; Parietal Lobe - pathology; Parietal Lobe - surgery; Pneumology; Pneumonectomy; Radiotherapy, Adjuvant; Reoperation; Tumors of the respiratory system and mediastinum; 10; Human; Lung disease; Nervous system diseases; Carcinoma; Respiratory disease; Etiopathogenesis; Surgical resection; Malignant tumor; Metastasis; Bronchopulmonary; Cerebral disorder; Case study; Treatment; Surgery; Central nervous system disease; Bronchus disease; Adult; Diagnosis; Brain (vertebrata)
• ISSN: 0003-4975; 1552-6259
• DOI: 10.1016/S0003-4975(02)04396-5

We report a patient with a brain metastasis that presented 5 years before the primary adenocarcinoma of the lung from which it originated. The metastasis and the primary tumor were removed. To confirm their common origin, we used comparative genomic hybridization. We have named this type of metastasis “messenger metachronous metastasis.” The patient remains well 79 months after the brain metastasectomy and 18 months after the lung surgery.