The Antibacterial Activity of Lavender Essential Oil Alone and In Combination with Octenidine Dihydrochloride against MRSA Strains

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 1; p. 95
• Main Authors: Kwiatkowski, Paweł, Łopusiewicz, Łukasz, Kostek, Mateusz, Drozłowska, Emilia, Pruss, Agata, Wojciuk, Bartosz, Sienkiewicz, Monika, Zielińska-Bliźniewska, Hanna, Dołęgowska, Barbara
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26-12-2019; MDPI
• Subjects: Antibacterial activity; Antibiotics; Antiseptics; Drug resistance; Drug Synergism; Drug Therapy, Combination; Essential oils; ftir; Influence; Lavandula - chemistry; lavender essential oil; Lavender oil; Methicillin; Methicillin-Resistant Staphylococcus aureus - drug effects; Microbial Sensitivity Tests; Molecular Structure; mrsa; Nosocomial infections; octenidine dihydrochloride; Oils & fats; Oils, Volatile - chemistry; Oils, Volatile - pharmacology; Plant Oils - chemistry; Plant Oils - pharmacology; Production increases; Pyridines - chemistry; Pyridines - pharmacology; Skin; Spectroscopy, Fourier Transform Infrared; Staphylococcus aureus; Staphylococcus infections; Strains (organisms); synergistic activity; Virulence; Wound healing; synergistic activity; FTIR; lavender essential oil; octenidine dihydrochloride; MRSA
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules25010095

In the post-antibiotic era the issue of bacterial resistance refers not only to antibiotics themselves but also to common antiseptics like octenidine dihydrochloride (OCT). This appears as an emerging challenge in terms of preventing staphylococcal infections, which are both potentially severe and easy to transfer horizontally. Essential oils have shown synergisms both with antibiotics and antiseptics. Therefore the aim of this study was to investigate the impact of lavender essential oil (LEO) on OCT efficiency towards methicillin-resistant
strains (MRSA). The LEO analyzed in this study increased the OCT's susceptibility against MRSA strains. Subsequent FTIR analysis revealed cellular wall modifications in MRSA strain cultured in media supplemented with OCT or LEO/OCT. In conclusion, LEO appears to be a promising candidate for an efficient enhancer of conventional antiseptics.