Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 7; p. 1703
• Main Authors: Kazi, Mohsin, Shahba, Ahmad A, Alrashoud, Saad, Alwadei, Majed, Sherif, Abdelrahman Y, Alanazi, Fars K
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08-04-2020; MDPI
• Subjects: Administration, Oral; Adsorption; Alkaloids - administration & dosage; Alkaloids - chemistry; Benzodioxoles - administration & dosage; Benzodioxoles - chemistry; bio-SNEDDS; Bioavailability; Biocompatible Materials - chemistry; Biological activity; Calorimetry; Calorimetry, Differential Scanning; combination therapy; Curcumin; Curcumin - administration & dosage; Curcumin - chemistry; curcumin and piperine; Differential scanning calorimetry; Dissolution; dissolution improvement; Droplets; Drug delivery; Drug Delivery Systems; Drug development; Drugs; Emulsions - chemistry; Equilibrium; Fourier analysis; Fourier transforms; Health care; Hydrogen-Ion Concentration; Infrared spectroscopy; Lipids; Nanoparticles - chemistry; Oils & fats; Particle Size; Piperidines - administration & dosage; Piperidines - chemistry; Piperine; Polyunsaturated Alkamides - administration & dosage; Polyunsaturated Alkamides - chemistry; Scanning electron microscopy; self-nanoemulsifying drug delivery systems (SNEDDS); Solidification; solidification technique; Solids; Solubilization; Spectroscopy, Fourier Transform Infrared; Spectrum analysis; Static Electricity; X ray powder diffraction; X-Ray Diffraction; bio-SNEDDS; combination therapy; dissolution improvement; self-nanoemulsifying drug delivery systems (SNEDDS); curcumin and piperine; solidification technique
• DOI: 10.3390/molecules25071703
• EISSN: 1420-3049

: Bioactive oils of natural origin have gained huge interests from health care professionals and patients.
: To design a bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS) comprising curcumin (CUR) and piperine (PP) by incorporating bioactive natural oils in the formulation.
: The self-emulsifying properties of apricot, avocado, black seed and
seed oils were screened within various SNEDDS formulations. Each liquid SNEDDS formulation was loaded with both CUR and PP. The optimal liquid SNEDDS were solidified using Aeroperl
and Neusilin
at 1:1
/
ratio. Liquid and solid SNEDDS were characterized by droplet size analysis, equilibrium solubility, scanning electron microscopy, X-ray powder diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy. In-vitro dissolution studies were performed to evaluate the efficiency of CUR and PP release from solid Bio-SNEDDS.
: The liquid SNEDDS comprised of black seed oil exhibited excellent self-emulsification performance, low droplet size along with transparent appearance. The inclusion of the cosolvent Transcutol P improved the solubilization capacity of both CUR and PP. The liquid SNEDDS were efficiently solidified using the two adsorbents and presented the drugs within amorphous state. In particular, SNEDDS comprised of black seed oil/Imwitor988/Transcutol P/Cremophor RH40 (20/20/10/50) and when solidified with Neusilin showed enhanced CUR and PP release (up to 60% and 77%, respectively). In addition, this formulation efficiently delivers the highly bioactive black seed oil to the patient. Conclusions: The optimized Bio-SNEDDS comprising black seed oil showed outstanding self-emulsification characteristics along with enhanced CUR/PP dissolution upon solidification.