Isolation of 1-(3',4'-Dihydroxyphenyl)-3-(2″,4″,6″-trihydroxyphenyl)-propan-2-ol from Grape Seed Extract and Evaluation of its Antioxidant and Antispasmodic Potential

HPLC profiling of phenolics in grape seed extracts revealed a prominent peak of an unknown substance with concentrations up to 5.3%. Spectroscopic data allowed the identification of the compound as 1-(3',4'-dihydroxyphenyl)-3-(2″,4″,6″-trihydroxyphenyl)-propan-2-ol. is known to be produced...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 24; no. 13; p. 2466
Main Authors:	Gleńsk, Michał, Hurst, William J, Glinski, Vitold B, Bednarski, Marek, Gliński, Jan A
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 04-07-2019 MDPI
Subjects:	1-(3′,4′-dihydroxyphenyl)-3-(2″,4″,6″-trihydroxyphenyl)-propan-2-ol 2-Propanol - isolation & purification 2-Propanol - pharmacology 3,4-diHPP-2-ol Acids Anaerobic bacteria Anaerobic processes Animals antioxidant activity Antioxidants Antioxidants - pharmacology antispasmodic effect Bacteria Catechin Communication Contraction Dimerization Epicatechin Free Radical Scavengers - pharmacology Fruits Gallic acid grape seed extract Grape Seed Extract - chemistry Grapes Guinea Pigs High-performance liquid chromatography Histamine Ileum Intestine Isopropyl alcohol Liquid chromatography Male marker for grape seed extract Metabolites Microbiota Muscle relaxants Parasympathetic nervous system Parasympatholytics - pharmacology Phenols Phenols - chemistry Plant extracts Polyphenols procyanidins Seeds Small intestine Smooth muscle Tea France United States > US phenols 1-(3′,4′-dihydroxyphenyl)-3-(2″,4″,6″-trihydroxyphenyl)-propan-2-ol grape seed extract procyanidins marker for grape seed extract antispasmodic effect antioxidant activity 3,4-diHPP-2-ol
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