Oxy-nitroso shielding burst model of cold atmospheric plasma therapeutics

Abstract It is postulated that cold atmospheric plasma (CAP) can trigger a therapeutic shielding response in tissue by creating a time- and space-localized, burst-like form of oxy-nitrosative stress on near-surface exposed cells through the flux of plasma-generated reactive oxygen and nitrogen speci...

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Bibliographic Details
Published in:	Clinical plasma medicine Vol. 2; no. 2; pp. 38 - 49
Main Author:	Graves, David B
Format:	Journal Article
Language:	English
Published:	Elsevier GmbH 01-12-2014 Elsevier
Subjects:	Advanced Basic Science Bystander effect Cold atmospheric plasma Hormesis Internal Medicine Plasma medicine Reactive oxygen and nitrogen species Hormesis Cold atmospheric plasma Bystander effect Reactive oxygen and nitrogen species Plasma medicine
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Summary:	Abstract It is postulated that cold atmospheric plasma (CAP) can trigger a therapeutic shielding response in tissue by creating a time- and space-localized, burst-like form of oxy-nitrosative stress on near-surface exposed cells through the flux of plasma-generated reactive oxygen and nitrogen species (RONS). RONS-exposed surface layers of cells communicate to the deeper levels of tissue via a form of the ‘bystander effect,’ similar to responses to other forms of cell stress. In this proposed model of CAP therapeutics, the plasma stimulates a cellular survival mechanism through which aerobic organisms shield themselves from infection and other challenges.
Bibliography:	USDOE Office of Science (SC), Fusion Energy Sciences (FES)
ISSN:	2212-8166 2212-8166
DOI:	10.1016/j.cpme.2014.11.001