Is Protein BLAST a thing of the past?

Will protein structure search tools like AlphaFold replace protein sequence search with BLAST? We discuss the promises, using structure search for remote homology detection, and why protein BLAST, as the leading sequence search tool, should strive to incorporate structural information

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; p. 8195
Main Authors:	Al-Fatlawi, Ali, Menzel, Martin, Schroeder, Michael
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 11-12-2023 Nature Publishing Group Nature Portfolio
Subjects:	631/114 631/1647/48 631/181 Amino acid sequence Comment Homology Humanities and Social Sciences Molecular biology multidisciplinary Neural networks Protein structure Proteins Science Science (multidisciplinary) Searching
Online Access:	Get full text
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Description
Summary:	Will protein structure search tools like AlphaFold replace protein sequence search with BLAST? We discuss the promises, using structure search for remote homology detection, and why protein BLAST, as the leading sequence search tool, should strive to incorporate structural information
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-023-44082-5