Guidelines for the use of human immunoglobulin therapy in patients with primary immunodeficiencies in Latin America

• Published in: Allergologia et immunopathologia Vol. 42; no. 3; p. 245
• Main Authors: Condino-Neto, A, Costa-Carvalho, B T, Grumach, A S, King, A, Bezrodnik, L, Oleastro, M, Leiva, L, Porras, O, Espinosa-Rosales, F J, Franco, J L, Sorensen, R U
• Format: Journal Article
• Language: English
• Published: Spain 01-05-2014
• Subjects: Guidelines as Topic; Humans; Immunization, Passive - methods; Immunoglobulins, Intravenous - therapeutic use; Immunologic Deficiency Syndromes - immunology; Immunologic Deficiency Syndromes - therapy; Latin America; Latin America; Intravenous immunoglobulin; Subcutaneous immunoglobulin; Immunoglobulin replacement therapy; Guidelines; Latin America; Primary immunodeficiency
• ISSN: 1578-1267
• DOI: 10.1016/j.aller.2012.09.006

Antibodies are an essential component of the adaptative immune response and hold long-term memory of the immunological experiences throughout life. Antibody defects represent approximately half of the well-known primary immunodeficiencies requiring immunoglobulin replacement therapy. In this article, the authors review the current indications and therapeutic protocols in the Latin American environment. Immunoglobulin replacement therapy has been a safe procedure that induces dramatic positive changes in the clinical outcome of patients who carry antibody defects.