Elevations in Tumor Necrosis Factor Alpha and Interleukin 6 From Neuronal-Derived Extracellular Vesicles in Repeated Low-Level Blast Exposed Personnel
The purpose of this pilot study was to determine if military service members with histories of hundreds to thousands of low-level blast exposures (i. e., experienced breachers) had different levels of serum and neuronal-derived extracellular vesicle (EV) concentrations of interleukin (IL)-6, IL-10,...
Saved in:
| Published in: | Frontiers in neurology Vol. 13; p. 723923 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Switzerland
Frontiers Media S.A
21-04-2022
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | The purpose of this pilot study was to determine if military service members with histories of hundreds to thousands of low-level blast exposures (i. e., experienced breachers) had different levels of serum and neuronal-derived extracellular vesicle (EV) concentrations of interleukin (IL)-6, IL-10, and tumor necrosis factor alpha (TNFα), compared to matched controls, and if these biomarkers related to neurobehavioral symptoms.
Participants were experienced breachers (
= 20) and matched controls without blast exposures (
= 14). Neuronal-derived EVs were isolated from serum and identified with mouse anti-human CD171. Serum and neuronal-derived EVs were analyzed for IL-6, IL-10, and TNFα using an ultra-sensitive assay.
Serum TNFα concentrations were decreased in breachers when compared to control concentrations (
< 0.01). There were no differences in serum concentrations of IL-6, IL-10, or the IL-6/IL-10 ratio between breachers and controls (
's > 0.01). In neuronal-derived EVs, TNFα and IL-6 levels were increased in breachers compared to controls (
's < 0.01), and IL-10 levels were decreased in the breacher group compared to controls (
< 0.01). In breachers the IL-6/IL-10 ratio in neuronal-derived EVs was higher compared to controls, which correlated with higher total Rivermead Post-concussion Questionnaire (RPQ) scores (
's < 0.05).
These findings suggest that exposure of personnel to high numbers of low-level blast over a career may result in enduring central inflammation that is associated with chronic neurological symptoms. The data also suggest that peripheral markers of inflammation are not necessarily adequate surrogates for central neuroinflammation. |
|---|---|
| AbstractList | The purpose of this pilot study was to determine if military service members with histories of hundreds to thousands of low-level blast exposures (i. e., experienced breachers) had different levels of serum and neuronal-derived extracellular vesicle (EV) concentrations of interleukin (IL)-6, IL-10, and tumor necrosis factor alpha (TNFα), compared to matched controls, and if these biomarkers related to neurobehavioral symptoms.
Participants were experienced breachers (
= 20) and matched controls without blast exposures (
= 14). Neuronal-derived EVs were isolated from serum and identified with mouse anti-human CD171. Serum and neuronal-derived EVs were analyzed for IL-6, IL-10, and TNFα using an ultra-sensitive assay.
Serum TNFα concentrations were decreased in breachers when compared to control concentrations (
< 0.01). There were no differences in serum concentrations of IL-6, IL-10, or the IL-6/IL-10 ratio between breachers and controls (
's > 0.01). In neuronal-derived EVs, TNFα and IL-6 levels were increased in breachers compared to controls (
's < 0.01), and IL-10 levels were decreased in the breacher group compared to controls (
< 0.01). In breachers the IL-6/IL-10 ratio in neuronal-derived EVs was higher compared to controls, which correlated with higher total Rivermead Post-concussion Questionnaire (RPQ) scores (
's < 0.05).
These findings suggest that exposure of personnel to high numbers of low-level blast over a career may result in enduring central inflammation that is associated with chronic neurological symptoms. The data also suggest that peripheral markers of inflammation are not necessarily adequate surrogates for central neuroinflammation. ObjectiveThe purpose of this pilot study was to determine if military service members with histories of hundreds to thousands of low-level blast exposures (i. e., experienced breachers) had different levels of serum and neuronal-derived extracellular vesicle (EV) concentrations of interleukin (IL)-6, IL-10, and tumor necrosis factor alpha (TNFα), compared to matched controls, and if these biomarkers related to neurobehavioral symptoms.MethodsParticipants were experienced breachers (n = 20) and matched controls without blast exposures (n = 14). Neuronal-derived EVs were isolated from serum and identified with mouse anti-human CD171. Serum and neuronal-derived EVs were analyzed for IL-6, IL-10, and TNFα using an ultra-sensitive assay.ResultsSerum TNFα concentrations were decreased in breachers when compared to control concentrations (p < 0.01). There were no differences in serum concentrations of IL-6, IL-10, or the IL-6/IL-10 ratio between breachers and controls (p's > 0.01). In neuronal-derived EVs, TNFα and IL-6 levels were increased in breachers compared to controls (p's < 0.01), and IL-10 levels were decreased in the breacher group compared to controls (p < 0.01). In breachers the IL-6/IL-10 ratio in neuronal-derived EVs was higher compared to controls, which correlated with higher total Rivermead Post-concussion Questionnaire (RPQ) scores (p's < 0.05).ConclusionsThese findings suggest that exposure of personnel to high numbers of low-level blast over a career may result in enduring central inflammation that is associated with chronic neurological symptoms. The data also suggest that peripheral markers of inflammation are not necessarily adequate surrogates for central neuroinflammation. The purpose of this pilot study was to determine if military service members with histories of hundreds to thousands of low-level blast exposures (i. e., experienced breachers) had different levels of serum and neuronal-derived extracellular vesicle (EV) concentrations of interleukin (IL)-6, IL-10, and tumor necrosis factor alpha (TNFα), compared to matched controls, and if these biomarkers related to neurobehavioral symptoms. Participants were experienced breachers (n = 20) and matched controls without blast exposures (n = 14). Neuronal-derived EVs were isolated from serum and identified with mouse anti-human CD171. Serum and neuronal-derived EVs were analyzed for IL-6, IL-10, and TNFα using an ultra-sensitive assay. Serum TNFα concentrations were decreased in breachers when compared to control concentrations (p < 0.01). There were no differences in serum concentrations of IL-6, IL-10, or the IL-6/IL-10 ratio between breachers and controls (p's > 0.01). In neuronal-derived EVs, TNFα and IL-6 levels were increased in breachers compared to controls (p's < 0.01), and IL-10 levels were decreased in the breacher group compared to controls (p < 0.01). In breachers the IL-6/IL-10 ratio in neuronal-derived EVs was higher compared to controls, which correlated with higher total Rivermead Post-concussion Questionnaire (RPQ) scores (p's < 0.05). These findings suggest that exposure of personnel to high numbers of low-level blast over a career may result in enduring central inflammation that is associated with chronic neurological symptoms. The data also suggest that peripheral markers of inflammation are not necessarily adequate surrogates for central neuroinflammation. |
| Author | Smith, Ethan G LoPresti, Matthew Gill, Jessica M Edwards, Katie A Wassermann, Eric M Polejaeva, Elena Ahlers, Stephen T Quick, Alycia Devoto, Christina Stone, James R Dell, Kristine C Walker, Peter Qu, Bao-Xi Modica, Claire M O'Brien, Meghan Leete, Jacqueline J Lai, Chen Carr, Walter |
| AuthorAffiliation | 10 Department of Radiology and Medical Imaging, University of Virginia , Charlottesville, VA , United States 8 Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research , Silver Spring, MD , United States 7 Department of Psychology, Pennsylvania State University , University Park, PA , United States 12 Naval Medical Research Center, Operational and Undersea Medicine Directorate , Silver Spring, MD , United States 5 National Institute of Neurological Disorders and Stroke, National Institutes of Health , Bethesda, MD , United States 3 School of Psychology, University of Glasgow , Glasgow , United Kingdom 6 VA San Diego Healthcare System , San Diego, CA , United States 11 Oak Ridge Institute for Science and Education , Oak Ridge, TN , United States 9 Joint Artificial Intelligence Center , Arlington, VA , United States 13 Center for Neuroscience and Regenerative Medicine, Uniformed Services of the Health Sciences , Bethesda, MD , United States 1 Biomarkers of Trauma, Na |
| AuthorAffiliation_xml | – name: 4 Naval Medical Research Center , Silver Spring, MD , United States – name: 9 Joint Artificial Intelligence Center , Arlington, VA , United States – name: 7 Department of Psychology, Pennsylvania State University , University Park, PA , United States – name: 10 Department of Radiology and Medical Imaging, University of Virginia , Charlottesville, VA , United States – name: 3 School of Psychology, University of Glasgow , Glasgow , United Kingdom – name: 12 Naval Medical Research Center, Operational and Undersea Medicine Directorate , Silver Spring, MD , United States – name: 6 VA San Diego Healthcare System , San Diego, CA , United States – name: 11 Oak Ridge Institute for Science and Education , Oak Ridge, TN , United States – name: 1 Biomarkers of Trauma, National Institute of Nursing Research, National Institutes of Health , Bethesda, MD , United States – name: 8 Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research , Silver Spring, MD , United States – name: 2 Henry M. Jackson Foundation for the Advancement of Military Medicine , Bethesda, MD , United States – name: 13 Center for Neuroscience and Regenerative Medicine, Uniformed Services of the Health Sciences , Bethesda, MD , United States – name: 5 National Institute of Neurological Disorders and Stroke, National Institutes of Health , Bethesda, MD , United States |
| Author_xml | – sequence: 1 givenname: Katie A surname: Edwards fullname: Edwards, Katie A organization: Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States – sequence: 2 givenname: Jacqueline J surname: Leete fullname: Leete, Jacqueline J organization: Biomarkers of Trauma, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, United States – sequence: 3 givenname: Ethan G surname: Smith fullname: Smith, Ethan G organization: Biomarkers of Trauma, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, United States – sequence: 4 givenname: Alycia surname: Quick fullname: Quick, Alycia organization: School of Psychology, University of Glasgow, Glasgow, United Kingdom – sequence: 5 givenname: Claire M surname: Modica fullname: Modica, Claire M organization: Naval Medical Research Center, Silver Spring, MD, United States – sequence: 6 givenname: Eric M surname: Wassermann fullname: Wassermann, Eric M organization: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States – sequence: 7 givenname: Elena surname: Polejaeva fullname: Polejaeva, Elena organization: VA San Diego Healthcare System, San Diego, CA, United States – sequence: 8 givenname: Kristine C surname: Dell fullname: Dell, Kristine C organization: Department of Psychology, Pennsylvania State University, University Park, PA, United States – sequence: 9 givenname: Matthew surname: LoPresti fullname: LoPresti, Matthew organization: Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, United States – sequence: 10 givenname: Peter surname: Walker fullname: Walker, Peter organization: Joint Artificial Intelligence Center, Arlington, VA, United States – sequence: 11 givenname: Meghan surname: O'Brien fullname: O'Brien, Meghan organization: Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States – sequence: 12 givenname: Chen surname: Lai fullname: Lai, Chen organization: Biomarkers of Trauma, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, United States – sequence: 13 givenname: Bao-Xi surname: Qu fullname: Qu, Bao-Xi organization: Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States – sequence: 14 givenname: Christina surname: Devoto fullname: Devoto, Christina organization: Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States – sequence: 15 givenname: Walter surname: Carr fullname: Carr, Walter organization: Oak Ridge Institute for Science and Education, Oak Ridge, TN, United States – sequence: 16 givenname: James R surname: Stone fullname: Stone, James R organization: Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States – sequence: 17 givenname: Stephen T surname: Ahlers fullname: Ahlers, Stephen T organization: Naval Medical Research Center, Operational and Undersea Medicine Directorate, Silver Spring, MD, United States – sequence: 18 givenname: Jessica M surname: Gill fullname: Gill, Jessica M organization: Center for Neuroscience and Regenerative Medicine, Uniformed Services of the Health Sciences, Bethesda, MD, United States |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35528741$$D View this record in MEDLINE/PubMed https://www.osti.gov/servlets/purl/1983095$$D View this record in Osti.gov |
| BookMark | eNpVkt9uFCEUxiemxtbaB_DGTLzyZlb-DQM3JrXu6iYbNaZ6S1g4005lYQvMqi_i88rs1qblBjh858fh8D2vjnzwUFUvMZpRKuTb3sMYZwQRMusIlYQ-qU4w56whRLZHD9bH1VlKN6gMKiXl9Fl1TNuWiI7hk-rv3MFO5yH4VA--vhw3IdafwcSQhlQvtMllf-6217rW3tZLnyE6GH8WLa8XMWyKeIzBa9d8gDjswNbz3zlqA86NTsf6B6TBONjTv8EWdC6SVfjVrGAHrn7vdMolZRtSiX-FmIL34F5UT3vtEpzdzafV98X88uJTs_rycXlxvmoMkyQ3GoHobI-lAcMtWnPCgBjTGsytxQQZ0oHtNLMYKBFrhoQRVnCLW2p6gig9rZYHrg36Rm3jsNHxjwp6UPtAiFdKxzw9QLGJikTLBetZx4QQncCEGIEIXnPMCuvdgbUd1xuwBnzpg3sEfXzih2t1FXZKog61vC2A1wdASHlQyQwZzLWZ-mGywlJQJCfRm7tbYrgdIWW1GdLUbe0hjEkRXmoRrUSySPFBOv1mitDf14KRmjyk9h5Sk4fUwUMl59XDR9xn_HcM_Qdn6cZz |
| CitedBy_id | crossref_primary_10_3390_ijms25063549 crossref_primary_10_1089_neu_2022_0282 crossref_primary_10_1093_milmed_usae268 crossref_primary_10_3390_ijms25021150 crossref_primary_10_1089_neu_2023_0284 crossref_primary_10_1080_02699052_2024_2371975 crossref_primary_10_1089_neu_2023_0309 |
| Cites_doi | 10.1080/02699052.2018.1483530 10.1097/TA.0000000000000468 10.1186/s12974-019-1624-z 10.7205/MILMED-D-15-00137 10.1021/ac103161b 10.1038/s41598-021-87180-4 10.1096/fj.201902842R 10.1089/neu.2020.7141 10.3389/fneur.2018.00239 10.1111/jnc.13607 10.1038/s41598-018-27190-x 10.1016/j.bbi.2017.02.015 10.1096/fj.201802319R 10.1089/neu.2019.6933 10.1097/HTR.0000000000000064 10.3389/fpsyt.2019.00632 10.1177/2211068215589580 10.1038/s41598-021-82875-0 10.1007/s12035-018-1054-4 10.3389/fnins.2019.01059 10.1097/JNN.0b013e3182527690 10.1002/prca.201400114 10.3892/mmr.2016.4948 10.1038/s41598-021-97913-0 10.1001/jamaneurol.2015.1383 10.1089/neu.2019.6711 10.1080/02699052.2018.1471738 10.3389/fnmol.2020.00038 10.1191/0269215505cr905oa 10.1212/WNL.0000000000010087 10.1177/0963689717714098 10.3389/fneur.2020.00091 10.1007/BF00868811 10.3389/fneur.2013.00018 10.1089/neu.2019.6826 10.3389/fnins.2019.01005 10.1002/jcp.28139 10.3390/cells9040977 |
| ContentType | Journal Article |
| Copyright | Copyright © 2022 Edwards, Leete, Smith, Quick, Modica, Wassermann, Polejaeva, Dell, LoPresti, Walker, O'Brien, Lai, Qu, Devoto, Carr, Stone, Ahlers and Gill. Copyright © 2022 Edwards, Leete, Smith, Quick, Modica, Wassermann, Polejaeva, Dell, LoPresti, Walker, O'Brien, Lai, Qu, Devoto, Carr, Stone, Ahlers and Gill. 2022 Edwards, Leete, Smith, Quick, Modica, Wassermann, Polejaeva, Dell, LoPresti, Walker, O'Brien, Lai, Qu, Devoto, Carr, Stone, Ahlers and Gill |
| Copyright_xml | – notice: Copyright © 2022 Edwards, Leete, Smith, Quick, Modica, Wassermann, Polejaeva, Dell, LoPresti, Walker, O'Brien, Lai, Qu, Devoto, Carr, Stone, Ahlers and Gill. – notice: Copyright © 2022 Edwards, Leete, Smith, Quick, Modica, Wassermann, Polejaeva, Dell, LoPresti, Walker, O'Brien, Lai, Qu, Devoto, Carr, Stone, Ahlers and Gill. 2022 Edwards, Leete, Smith, Quick, Modica, Wassermann, Polejaeva, Dell, LoPresti, Walker, O'Brien, Lai, Qu, Devoto, Carr, Stone, Ahlers and Gill |
| CorporateAuthor | Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States) |
| CorporateAuthor_xml | – name: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States) |
| DBID | NPM AAYXX CITATION 7X8 OIOZB OTOTI 5PM DOA |
| DOI | 10.3389/fneur.2022.723923 |
| DatabaseName | PubMed CrossRef MEDLINE - Academic OSTI.GOV - Hybrid OSTI.GOV PubMed Central (Full Participant titles) Directory of Open Access Journals |
| DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: http://www.doaj.org/ sourceTypes: Open Website |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1664-2295 |
| EndPage | 723923 |
| ExternalDocumentID | oai_doaj_org_article_45c16085684f47488878122c8021b614 1983095 10_3389_fneur_2022_723923 35528741 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: ; – fundername: ; grantid: Intramural Research Program |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD ACGFO ACGFS ACXDI ADBBV ADRAZ AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV DIK E3Z EMOBN F5P GROUPED_DOAJ GX1 HYE IAO IEA IHR IHW IPNFZ KQ8 M48 M~E NPM O5R O5S OK1 P2P PGMZT RIG RNS RPM AAYXX CITATION 7X8 ABPTK ITC OIOZB OTOTI 5PM |
| ID | FETCH-LOGICAL-c492t-a0e87df19cec6d0b624e2cc5c16dd120c27ed7a4d1e328b408c8d86d153cf2033 |
| IEDL.DBID | RPM |
| ISSN | 1664-2295 |
| IngestDate | Tue Oct 22 15:15:15 EDT 2024 Tue Sep 17 21:23:56 EDT 2024 Mon Oct 30 03:58:57 EDT 2023 Thu Oct 24 23:39:58 EDT 2024 Thu Nov 21 22:09:52 EST 2024 Sat Sep 28 08:41:02 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | military extracellular vesicles neuroinflammation breacher blast |
| Language | English |
| License | Copyright © 2022 Edwards, Leete, Smith, Quick, Modica, Wassermann, Polejaeva, Dell, LoPresti, Walker, O'Brien, Lai, Qu, Devoto, Carr, Stone, Ahlers and Gill. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c492t-a0e87df19cec6d0b624e2cc5c16dd120c27ed7a4d1e328b408c8d86d153cf2033 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 SC0014664 USDOE Office of Science (SC) Edited by: Elham Rostami, Uppsala University Hospital, Sweden This article was submitted to Neurotrauma, a section of the journal Frontiers in Neurology Reviewed by: Keisuke Kawata, Indiana University Bloomington, United States; Maja Mustapic, Laboratory of Clinical Investigation, National Institute on Aging (NIH), United States |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070565/ |
| PMID | 35528741 |
| PQID | 2661485909 |
| PQPubID | 23479 |
| PageCount | 1 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_45c16085684f47488878122c8021b614 pubmedcentral_primary_oai_pubmedcentral_nih_gov_9070565 osti_scitechconnect_1983095 proquest_miscellaneous_2661485909 crossref_primary_10_3389_fneur_2022_723923 pubmed_primary_35528741 |
| PublicationCentury | 2000 |
| PublicationDate | 2022-04-21 |
| PublicationDateYYYYMMDD | 2022-04-21 |
| PublicationDate_xml | – month: 04 year: 2022 text: 2022-04-21 day: 21 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland – name: United States |
| PublicationTitle | Frontiers in neurology |
| PublicationTitleAlternate | Front Neurol |
| PublicationYear | 2022 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Ghai (B27) 2020; 37 Goetzl (B35) 2020; 34 Carr (B1) 2016; 181 Boukouris (B23) 2015; 9 Kenney (B9) 2018; 32 Goetzl (B32) 2020; 37 Stone (B11) 2020; 37 Devoto (B4) 2017; 26 Coppens (B37) 2019; 10 Rissin (B17) 2011; 83 Devoto (B26) 2020; 37 Peltz (B33) 2020; 95 Edwards (B16) 2021; 11 King (B13) 1995; 242 Wilson (B18) 2016; 21 Hornung (B7) 2020; 13 Sartori (B38) 2012; 44 Fitzgerald (B40) 2018; 8 Osier (B6) 2018; 55 Chen (B36) 2016; 13 Matuk (B29) 2021; 11 Carr (B2) 2015; 30 B39 Kawata (B34) 2018; 9 Rusiecki (B19) 2020; 17 Winston (B8) 2019; 13 Woodcock (B21) 2013; 4 Goetzl (B31) 2019; 33 Hinson (B20) 2015; 78 Muraoka (B30) 2019; 13 Olivera (B15) 2015; 72 Edwards (B5) 2020; 11 DiSabato (B22) 2016; 139 Mondello (B24) 2020; 9 Eyres (B14) 2005; 19 Gill (B10) 2018; 32 Gill (B3) 2017; 65 Flynn (B25) 2021; 11 Cheng (B28) 2019; 234 Weathers (B12) 1993 |
| References_xml | – volume: 32 start-page: 1276 year: 2018 ident: B9 article-title: Higher exosomal phosphorylated tau and total tau among veterans with combat-related repetitive chronic mild traumatic brain injury publication-title: Brain Inj. doi: 10.1080/02699052.2018.1483530 contributor: fullname: Kenney – volume: 78 start-page: 184 year: 2015 ident: B20 article-title: Clinical evidence of inflammation driving secondary brain injury: a systematic review publication-title: J Trauma Acute Care Surg. doi: 10.1097/TA.0000000000000468 contributor: fullname: Hinson – volume: 17 start-page: 20 year: 2020 ident: B19 article-title: Blast traumatic brain injury and serum inflammatory cytokines: a repeated measures case-control study among U.S. military service members publication-title: J Neuroinflammation. doi: 10.1186/s12974-019-1624-z contributor: fullname: Rusiecki – volume: 181 start-page: 28 year: 2016 ident: B1 article-title: Repeated low-level blast exposure: a descriptive human subjects study publication-title: Mil Med. doi: 10.7205/MILMED-D-15-00137 contributor: fullname: Carr – volume: 83 start-page: 2279 year: 2011 ident: B17 article-title: Simultaneous detection of single molecules and singulated ensembles of molecules enables immunoassays with broad dynamic range publication-title: Anal Chem. doi: 10.1021/ac103161b contributor: fullname: Rissin – volume: 11 start-page: 8186 year: 2021 ident: B29 article-title: The role of salivary vesicles as a potential inflammatory biomarker to detect traumatic brain injury in mixed martial artists publication-title: Sci Rep. doi: 10.1038/s41598-021-87180-4 contributor: fullname: Matuk – volume: 34 start-page: 3359 year: 2020 ident: B35 article-title: Traumatic brain injury increases plasma astrocyte-derived exosome levels of neurotoxic complement proteins publication-title: Faseb j. doi: 10.1096/fj.201902842R contributor: fullname: Goetzl – volume: 37 start-page: 2468 year: 2020 ident: B11 article-title: Functional and structural neuroimaging correlates of repetitive low-level blast exposure in career breachers publication-title: J Neurotrauma. doi: 10.1089/neu.2020.7141 contributor: fullname: Stone – volume: 9 start-page: 239 year: 2018 ident: B34 article-title: A preliminary report on brain-derived extracellular vesicle as novel blood biomarkers for sport-related concussions publication-title: Front Neurol. doi: 10.3389/fneur.2018.00239 contributor: fullname: Kawata – volume: 139 start-page: 136 year: 2016 ident: B22 article-title: Neuroinflammation: the devil is in the details publication-title: J Neurochem. doi: 10.1111/jnc.13607 contributor: fullname: DiSabato – volume: 8 start-page: 8973 year: 2018 ident: B40 article-title: A system of cytokines encapsulated in extracellular vesicles publication-title: Sci Rep. doi: 10.1038/s41598-018-27190-x contributor: fullname: Fitzgerald – volume: 65 start-page: 90 year: 2017 ident: B3 article-title: Moderate blast exposure results in increased IL-6 and TNFα in peripheral blood publication-title: Brain Behav Immun. doi: 10.1016/j.bbi.2017.02.015 contributor: fullname: Gill – volume: 33 start-page: 5082 year: 2019 ident: B31 article-title: Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury publication-title: Faseb j. doi: 10.1096/fj.201802319R contributor: fullname: Goetzl – volume: 37 start-page: 2482 year: 2020 ident: B26 article-title: Exosomal MicroRNAs in military personnel with mild traumatic brain injury: preliminary results from the chronic effects of neurotrauma consortium biomarker discovery project publication-title: J Neurotrauma. doi: 10.1089/neu.2019.6933 contributor: fullname: Devoto – volume: 30 start-page: 47 year: 2015 ident: B2 article-title: Relation of repeated low-level blast exposure with symptomology similar to concussion publication-title: J Head Trauma Rehabil. doi: 10.1097/HTR.0000000000000064 contributor: fullname: Carr – volume: 10 start-page: 632 year: 2019 ident: B37 article-title: The interplay of inflammatory processes and cognition in alcohol use disorders-a systematic review publication-title: Front Psychiatry. doi: 10.3389/fpsyt.2019.00632 contributor: fullname: Coppens – volume: 21 start-page: 533 year: 2016 ident: B18 article-title: The simoa HD-1 analyzer: a novel fully automated digital immunoassay analyzer with single-molecule sensitivity and multiplexing publication-title: J Lab Autom. doi: 10.1177/2211068215589580 contributor: fullname: Wilson – volume: 11 start-page: 3896 year: 2021 ident: B25 article-title: Extracellular vesicle concentrations of glial fibrillary acidic protein and neurofilament light measured 1 year after traumatic brain injury publication-title: Sci Rep. doi: 10.1038/s41598-021-82875-0 contributor: fullname: Flynn – volume: 55 start-page: 9280 year: 2018 ident: B6 article-title: Exosomes in acquired neurological disorders: new insights into pathophysiology and treatment publication-title: Mol Neurobiol. doi: 10.1007/s12035-018-1054-4 contributor: fullname: Osier – volume: 13 start-page: 1059 year: 2019 ident: B30 article-title: Proteomic profiling of extracellular vesicles isolated from cerebrospinal fluid of former national football league players at risk for chronic traumatic encephalopathy publication-title: Front Neurosci. doi: 10.3389/fnins.2019.01059 contributor: fullname: Muraoka – volume: 44 start-page: 206 year: 2012 ident: B38 article-title: The impact of inflammation on cognitive function in older adults: implications for healthcare practice and research publication-title: J Neurosci Nurs. doi: 10.1097/JNN.0b013e3182527690 contributor: fullname: Sartori – ident: B39 – volume: 9 start-page: 358 year: 2015 ident: B23 article-title: Exosomes in bodily fluids are a highly stable resource of disease biomarkers publication-title: Proteomics Clin Appl. doi: 10.1002/prca.201400114 contributor: fullname: Boukouris – volume: 13 start-page: 3391 year: 2016 ident: B36 article-title: Role of neuroinflammation in neurodegenerative diseases (Review) publication-title: Mol Med Rep. doi: 10.3892/mmr.2016.4948 contributor: fullname: Chen – volume: 11 start-page: 19527 year: 2021 ident: B16 article-title: Neuronally-derived tau is increased in experienced breachers and is associated with neurobehavioral symptoms publication-title: Sci Rep. doi: 10.1038/s41598-021-97913-0 contributor: fullname: Edwards – volume: 72 start-page: 1109 year: 2015 ident: B15 article-title: Peripheral total tau in military personnel who sustain traumatic brain injuries during deployment publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2015.1383 contributor: fullname: Olivera – volume: 37 start-page: 382 year: 2020 ident: B32 article-title: Neuron-derived plasma exosome proteins after remote traumatic brain injury publication-title: J Neurotrauma. doi: 10.1089/neu.2019.6711 contributor: fullname: Goetzl – volume: 32 start-page: 1277 year: 2018 ident: B10 article-title: Higher exosomal tau, amyloid-beta 42 and IL-10 are associated with mild TBIs and chronic symptoms in military personnel publication-title: Brain Inj. doi: 10.1080/02699052.2018.1471738 contributor: fullname: Gill – volume: 13 start-page: 38 year: 2020 ident: B7 article-title: CNS-derived blood exosomes as a promising source of biomarkers: opportunities and challenges publication-title: Front Mol Neurosci. doi: 10.3389/fnmol.2020.00038 contributor: fullname: Hornung – volume: 19 start-page: 878 year: 2005 ident: B14 article-title: Construct validity and reliability of the rivermead post-concussion symptoms questionnaire publication-title: Clin Rehabil. doi: 10.1191/0269215505cr905oa contributor: fullname: Eyres – volume: 95 start-page: e1126 year: 2020 ident: B33 article-title: Blood biomarkers of traumatic brain injury and cognitive impairment in older veterans publication-title: Neurology. doi: 10.1212/WNL.0000000000010087 contributor: fullname: Peltz – volume: 26 start-page: 1169 year: 2017 ident: B4 article-title: Inflammation relates to chronic behavioral and neurological symptoms in military personnel with traumatic brain injuries publication-title: Cell Transplant. doi: 10.1177/0963689717714098 contributor: fullname: Devoto – volume: 11 start-page: 91 year: 2020 ident: B5 article-title: A moderate blast exposure results in dysregulated gene network activity related to cell death, survival, structure, and metabolism publication-title: Front Neurol. doi: 10.3389/fneur.2020.00091 contributor: fullname: Edwards – volume: 242 start-page: 587 year: 1995 ident: B13 article-title: The rivermead post concussion symptoms questionnaire: a measure of symptoms commonly experienced after head injury and its reliability publication-title: J Neurol. doi: 10.1007/BF00868811 contributor: fullname: King – volume: 4 start-page: 18 year: 2013 ident: B21 article-title: The role of markers of inflammation in traumatic brain injury publication-title: Front Neurol. doi: 10.3389/fneur.2013.00018 contributor: fullname: Woodcock – volume: 37 start-page: 1418 year: 2020 ident: B27 article-title: Alterations in plasma microRNA and protein levels in war veterans with chronic mild traumatic brain injury publication-title: J Neurotrauma. doi: 10.1089/neu.2019.6826 contributor: fullname: Ghai – volume: 13 start-page: 1005 year: 2019 ident: B8 article-title: Assessing neuronal and astrocyte derived exosomes from individuals with mild traumatic brain injury for markers of neurodegeneration and cytotoxic activity publication-title: Front Neurosci. doi: 10.3389/fnins.2019.01005 contributor: fullname: Winston – volume: 234 start-page: 14377 year: 2019 ident: B28 article-title: Potential biomarkers to detect traumatic brain injury by the profiling of salivary extracellular vesicles publication-title: J Cell Physiol. doi: 10.1002/jcp.28139 contributor: fullname: Cheng – year: 1993 ident: B12 article-title: The PTSD Checklist (PCL): Reliability, Validity, and Diagnostic Utility publication-title: Paper Presented at Annual Convention of the International Society for Traumatic Stress Studies contributor: fullname: Weathers – volume: 9 year: 2020 ident: B24 article-title: Circulating brain injury exosomal proteins following moderate-to-severe traumatic brain injury: temporal profile, outcome prediction and therapy implications publication-title: Cells. doi: 10.3390/cells9040977 contributor: fullname: Mondello |
| SSID | ssj0000399363 |
| Score | 2.379691 |
| Snippet | The purpose of this pilot study was to determine if military service members with histories of hundreds to thousands of low-level blast exposures (i. e.,... ObjectiveThe purpose of this pilot study was to determine if military service members with histories of hundreds to thousands of low-level blast exposures (i.... |
| SourceID | doaj pubmedcentral osti proquest crossref pubmed |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | 723923 |
| SubjectTerms | BASIC BIOLOGICAL SCIENCES blast breacher extracellular vesicles military neuroinflammation Neurology |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagB8QF8Sb0ISNxQgqNHa8fx5buqodSIVEQNyt-RKy6TarNBvgl_N7O2NtVFyFx4RQpcZKJZ-z5xp58Q8hbB04xSizuMmkrCFBEUzaAm8vgpAC40Zg28Racflbn3_TJFGlyNqW-MCcs0wPnjjsUE88k4AKpRSsUmJtW4JO41-CcnGSZCbSSd4KpNAej35V13saEKMwctsgPCfEg5-8VB1BQbzmixNcPhx7G1d-w5p8pk3d80OwxebQGj_QoC_2E3IvdU_Lg43p7_Bn5PV3EvMQ60HlHL8arfknPIwowH-gsldahR_h3LW26QNNq4CKOl9BW0tmyv6KJqwPeUZ6AZf6IgU5_gSC4uo_pqvRrHFIaHT4doDvM49DkrP9ZnmHuET0GKL6CW677Ac5_SmC-i4vn5MtsevHhtFwXXii9MHxVNlXUKrTM-OhlqJzkInLvURMhMF55rmJQjQgs1lw7UWmvg5YBZk_f8qquX5Cdru_iK0KlbJhTzvigogh1bZhwDMImXzsAMpEV5N2tFux15tewEJegymxSmUWV2ayyghyjnjYNkRo7nQCDsWuDsf8ymILsopYtIAykyfXYEX5lmdE1wM2CvLlVvoWBhv3bdLEfB5uQjJ6YyhTkZTaGjSAA2rBuAHyN2jKTLUm3r3Tz74nM28CcC6D69f_4tF3yEHsLN7s42yM7q-UY98n9IYwHaXjcAIvUEsM priority: 102 providerName: Directory of Open Access Journals |
| Title | Elevations in Tumor Necrosis Factor Alpha and Interleukin 6 From Neuronal-Derived Extracellular Vesicles in Repeated Low-Level Blast Exposed Personnel |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/35528741 https://search.proquest.com/docview/2661485909 https://www.osti.gov/servlets/purl/1983095 https://pubmed.ncbi.nlm.nih.gov/PMC9070565 https://doaj.org/article/45c16085684f47488878122c8021b614 |
| Volume | 13 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELbYHhAXxJtQqIzECSm7seM4zrGPXfXQVpUoiJsVPwKr7iarzQb4JfxeZpyk6iJOnCI5djLyjD3f2OPPhHww4BS9xMtdsiqBAEWUcQm4OXZGCoAbZVEF3oLzT_nVV3U2R5qcbDwLE5L2rVlO69V6Wi-_h9zKzdrOxjyx2fXlKQR04Lez2YRMABveC9HD9IsuV6b9DiYEYMWsQmpICAU5n-Yc8ADenQNuFpne2Z47Cqz98GhgdP0Lcf6dOHnPEy2ekMcDhKTHvahPyQNfPyMPL4dN8ufk93zl-4XWli5retOtmy298ijAsqWLcMEOPcYztrSsHQ1rgivf3UJdSRfbZk0DYwf8Iz4D-_zhHZ3_AkFwjR-TVukX34ZOwq8DgIfZHKpcND_jC8xAoicAyHfQZNO0UH4dIH3tVy_I58X85vQ8Hq5fiK0o-C4uE69yV7HCeitdYiQXnlubWSadYzyxPPcuL4VjPuXKiERZ5ZR0MIfaiidp-pIc1E3tXxMqZclMbgrrci9cmhZMGAbBk00NwBnPIvJx1ILe9CwbGqIT1J4O2tOoPd1rLyInqKe7ikiQHQqa7Tc9mIkWKCbASalEJXKYpVQOUIZbBZjGACSJyCFqWQPOQLJcix1hd5oVKgXQGZH3o_I1DDfs37L2TdfqgGdUViRFRF71xnAnyGhTEcn3zGRP0v03YOGB0nuw6Df_3fKQPMIuwn0uzt6Sg9228-_IpHXdUVhmOAqD5A_C4xcH |
| link.rule.ids | 230,315,729,782,786,866,887,2106,27933,27934,53800,53802 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELbYRQIuy3MhLA8jcUJKGzuO4xz30aqItlqJgrhZie1ARZtUTbvwS_i9zDjpaos47SmSYycTz9jzjT35TMj7Apyik3i4S1JGEKCIPMwBN4e2kALgRp6Vnrdg9DmdflMXA6TJSXb_wvikfVPMe9Vi2avmP3xu5Wpp-rs8sf7l5BwCOvDbSf-A3IXxGkU3gnQ_AaPTlXG7hwkhWNYvkRwSgkHOeykHRICn54CjRa53tueQPG8_XGoYX__DnP-mTt7wRcOHt_yKR-SoA5_0tL39mNxx1RNyb9Jtrz8lfwYL1y7RNnRe0dl2Wa_p1KHg84YO_dE89BT_zqV5ZalfTVy47U-oK-lwXS-p5_qAd4QXYNlXztLBb_gA3B3AdFf61TVeMHw6QH_wA1BlXP8Kx5i7RM8Aym-gyapuoPzSBwOVWzwjX4aD2fko7A5uCI3I-CbMI6dSW7LMOCNtVEguHDcmMUxay3hkeOpsmgvLXMxVISJllFXSwuxrSh7F8TE5rOrKvSBUypwVaZEZmzph4zhjomAQdpm4ACDkWEA-7LSnVy0_h4a4BrWuvdY1al23Wg_IGer3uiJSa_uCev1dd6rRAsUEICqVKEUK85tKAQRxowANFQBmAnKC1qEBoSDNrsGOMBvNMhUDXA3Iu53RaBio2L955eptoz0SUkkWZQF53hrRtSA7WwxIumdee5Lu3wGr8mTgnRW9vHXLt-T-aDYZ6_HH6acT8gC7C3fLOHtFDjfrrXtNDhq7feOH2F9atSua |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELfYkCZexjdk48NIPCGliR3XSR63tdEQXVWJgXizEtsZFW1SNQ3wl_D3cuek1Yp4gqdIiZNcfGff7-zL7wh5W4BTtBKLuwzLEAIUkfs54GbfFFIA3MjT0vEWXH6Mp1-S0RhpcnalvlzSvi7mg2qxHFTzry63crXUwTZPLJhdXUBAB357GKxMGRyQuzBmQ34rUHeTMDpeGXX7mBCGpUGJBJEQEHI-iDmgAqygA84W-d7ZnlNy3P1wqGGM_Q13_pk-ecsfZff_40sekOMehNKzrslDcsdWj8jRVb_N_pj8Gi9st1Tb0HlFr9tlvaZTi8LPG5q5Ej30DP_SpXllqFtVXNj2G7SVNFvXS-o4P-Ad_ggs_Ls1dPwTPgJ3CTDtlX62jRMOnw4hAPgDaDKpf_gTzGGi5wDpN3DLqm7g_MwFBZVdPCGfsvH1xaXfF3DwtUj5xs9Dm8SmZKm2WpqwkFxYrvVQM2kM46HmsTVxLgyzEU8KESY6MYk0MAvrkodR9JQcVnVlnxMqZc6KuEi1ia0wUZQyUTAIv3RUACCyzCPvthpUq46nQ0F8g5pXTvMKNa86zXvkHHW8a4gU2-5Evb5RvXqUQDEBkMpElCKGeS6JAQxxDbbGCgA1HjlFC1GAVJBuV2NH6I1iaRIBbPXIm63hKBiw2L95Zeu2UQ4RJcM0TD3yrDOknSBbe_RIvGdie5LuXwHLcqTgvSWd_POdr8nRbJSpyfvph1NyD3sLN804e0EON-vWviQHjWlfuVH2G7B1Lho |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Elevations+in+Tumor+Necrosis+Factor+Alpha+and+Interleukin+6+From+Neuronal-Derived+Extracellular+Vesicles+in+Repeated+Low-Level+Blast+Exposed+Personnel&rft.jtitle=Frontiers+in+neurology&rft.au=Edwards%2C+Katie+A&rft.au=Leete%2C+Jacqueline+J&rft.au=Smith%2C+Ethan+G&rft.au=Quick%2C+Alycia&rft.date=2022-04-21&rft.issn=1664-2295&rft.eissn=1664-2295&rft.volume=13&rft.spage=723923&rft.epage=723923&rft_id=info:doi/10.3389%2Ffneur.2022.723923&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-2295&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-2295&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-2295&client=summon |