Composition and diversity analysis of the TCR CDR3 repertoire in patients with idiopathic orbital inflammation using high-throughput sequencing

Background Idiopathic orbital inflammation (IOI) is a nonspecific orbital inflammatory disease with the third highest prevalence among orbital diseases, and its pathogenesis is associated with T-cell-mediated immune responses. This study aimed to investigate the differences in T-cell receptor (TCR)...

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Bibliographic Details
Published in:	BMC ophthalmology Vol. 23; no. 1; pp. 1 - 491
Main Authors:	Fang, Yenan, Shen, Bingyan, Dai, Qin, Xie, Qiqi, Li, Xinyu, Wu, Wencan, Wang, Min
Format:	Journal Article
Language:	English
Published:	London BioMed Central Ltd 04-12-2023 BioMed Central BMC
Subjects:	Care and treatment Complementarity-determining region 3 Corticosteroids Disease Entropy Ethylenediaminetetraacetic acid Glucocorticoid sensitivity Glucocorticoids High-throughput sequencing Idiopathic orbital inflammation Immune response Immune response (cell-mediated) Immune status Inflammation Inflammatory diseases J gene Leukocytes (mononuclear) Lymphocytes Lymphocytes T Magnetic resonance imaging Next-generation sequencing Pathogenesis Peptides Peripheral blood mononuclear cells Software T cell receptors T cells T-cell receptor Germany
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