Effects of amnesic doses of reserpine or syrosingopine on mouse brain acetylcholine levels

The effects of reserpine and syrosingopine on mouse whole brain acetylcholine levels were examined. At 2 or 24 hr following injection, the brains were removed and analyzed by mass spectrometry. No differences were found between drug-treated and control mice in the acetylcholine content of the brain...

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Bibliographic Details
Published in:	Pharmacology, biochemistry and behavior Vol. 24; no. 5; p. 1457
Main Authors:	Palfai, T, Wichlinski, L, Brown, H A, Brown, O M
Format:	Journal Article
Language:	English
Published:	United States 01-05-1986
Subjects:	Acetylcholine - metabolism Amnesia - chemically induced Animals Brain - metabolism Gas Chromatography-Mass Spectrometry Male Mice Reserpine - pharmacology
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Summary:	The effects of reserpine and syrosingopine on mouse whole brain acetylcholine levels were examined. At 2 or 24 hr following injection, the brains were removed and analyzed by mass spectrometry. No differences were found between drug-treated and control mice in the acetylcholine content of the brain at either time interval. The results suggest that whole brain acetylcholine levels do not predict the amnesic effects of either reserpine or syrosingopine.
ISSN:	0091-3057
DOI:	10.1016/0091-3057(86)90210-8