Future perspective and clinical applicability of the combined use of plasma phosphorylated tau 181 and neurofilament light chain in Subjective Cognitive Decline and Mild Cognitive Impairment

We aimed to assess diagnostic accuracy of plasma p-tau181 and NfL separately and in combination in discriminating Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI) patients carrying Alzheimer’s Disease (AD) pathology from non-carriers; to propose a flowchart for the interpretati...

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Bibliographic Details
Published in:	Scientific reports Vol. 14; no. 1; pp. 11307 - 12
Main Authors:	Giacomucci, Giulia, Mazzeo, Salvatore, Ingannato, Assunta, Crucitti, Chiara, Bagnoli, Silvia, Padiglioni, Sonia, Romano, Lucrezia, Galdo, Giulia, Emiliani, Filippo, Frigerio, Daniele, Ferrari, Camilla, Moschini, Valentina, Morinelli, Carmen, Notarelli, Antonella, Sorbi, Sandro, Nacmias, Benedetta, Bessi, Valentina
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 17-05-2024 Nature Publishing Group Nature Portfolio
Subjects:	692/617 692/617/375/132 Accuracy Aged Alzheimer Disease - blood Alzheimer Disease - diagnosis Alzheimer's disease Amyloid beta-Peptides - blood Amyloid beta-Peptides - cerebrospinal fluid Biomarkers Biomarkers - blood Cerebrospinal fluid Cognitive ability Cognitive Dysfunction - blood Cognitive Dysfunction - diagnosis Female Humanities and Social Sciences Humans Male Middle Aged Mild Cognitive Impairment multidisciplinary Neurodegenerative diseases Neurofilament Proteins - blood NfL p-tau181 Pathology Phosphorylation Plasma Plasma biomarkers Science Science (multidisciplinary) Subjective Cognitive Decline Tau protein tau Proteins - blood tau Proteins - cerebrospinal fluid Alzheimer’s Disease p-tau181 Mild Cognitive Impairment Plasma biomarkers NfL Subjective Cognitive Decline
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