Mass transport model through the skin by microencapsulation system

• Published in: Journal of microencapsulation Vol. 32; no. 4; pp. 358 - 363
• Main Authors: Carreras, Núria, Alonso, Cristina, Martí, Meritxell, Lis, Manel J.
• Format: Journal Article Publication
• Language: English
• Published: England Informa Healthcare 01-01-2015
• Subjects: Administració; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics; Biofunctional textile; biofunctional textile substrates; Capsules - chemistry; Drug Compounding; Drug Delivery Systems; Enginyeria química; Enginyeria tèxtil; Ibuprofen; Ibuprofen - administration & dosage; Ibuprofen - pharmacokinetics; in vitro skin delivery; Indústries químiques; Innovacions tecnològiques; Kinetics; Mass transport; mathematical model; Medicaments; microcapsules; Microencapsulation; Models, Biological; Nanoestructures; percutaneous absorption; Permeability; Química tèxtil; Skin; Skin - metabolism; Skin Absorption; Swine; Technological innovations; Teixits; Teixits i tèxtils; Teixits mèdics; Textiles - analysis; therapeutic use; Àrees temàtiques de la UPC; Ús terapèutic; Biofunctional textile; ibuprofen; in vitro skin delivery; microencapsulation
• ISSN: 0265-2048; 1464-5246
• DOI: 10.3109/02652048.2015.1028495

Skin drug delivery can be subdivided into topical and transdermal administration. Transdermal administration can take advantage of chemical and physical strategies that can improve skin permeability and allow drug penetration. In this study, the development of a skin penetration profile was carried out by an in vitro technique for a microencapsulated system of ibuprofen. Release experiments were performed using percutaneous absorption tests to determine the evolution of the principle present in each of the different skin compartments as a function of time. A general kinetic model for a microencapsulated structure as a mass transport system through the skin was applied:
This model could predict the penetration profile of encapsulated substances through skin from biofunctional textiles as well as estimate the dosage profile of the active principle. The apparent diffusion coefficients found were 1.20 × 10
−7 
cm/s for the stratum corneum and higher for the rest of the skin 6.67 × 10
−6 
cm/s.