Influence of pyruvate on economy of contraction in isolated rabbit myocardium
Background Treatment of acute heart failure frequently requires positive-inotropic stimulation. However, there is still no inotropic agent available, which combines a favourable haemodynamic profile with low expenditure for energy metabolism. Pyruvate exhibits positive inotropic effects in vitro and...
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| Published in: | European journal of heart failure Vol. 9; no. 8; pp. 754 - 761 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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England
Blackwell Publishing Ltd
01-08-2007
Elsevier |
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| Abstract | Background
Treatment of acute heart failure frequently requires positive-inotropic stimulation. However, there is still no inotropic agent available, which combines a favourable haemodynamic profile with low expenditure for energy metabolism. Pyruvate exhibits positive inotropic effects in vitro and in patients with heart failure. The effect on myocardial energy metabolism however remains unclear, but is meaningful in light of a clinical application.
Aims and methods
We investigated the influence of pyruvate on contractility and oxygen consumption in isolated isometric contracting rabbit myocardium compared to β-adrenergic stimulation with isoproterenol.
Results
Pyruvate (30 mM) increased developed force from 18.7±4.1 to 50.8±12.1 mN/mm2 (n=10, p<0.01). Force-time integral (FTI) increased by 329%, oxygen consumption assessed by diffusion-microelectrode technique increased from 2.86±0.30 mlO2/min*100 g to 6.28±1.28 mlO2/min*100 g (n=7, p<0.05). Economy of myocardial contraction calculated as the ratio of total FTI to oxygen consumption remained unchanged. In contrast, while isoproterenol (10 μM) produced a comparable increase in developed force from 21.4±8.3 to 67.3±15mN/mm2 (n=7, p<0.01), FTI increased only by 260% and MVO2 increased from 2.96±0.43 to 6.12±1.01 mlO2/min*100 g (n=7, p<0.01); thus, economy decreased by 23% (n=7, p<0.05).
Conclusion
Pyruvate does not impair economy of myocardial contraction while isoproterenol decreases economy. Regarding energy expenditure, pyruvate appears superior to isoproterenol for the purpose of positive inotropic stimulation. |
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| AbstractList | Background
Treatment of acute heart failure frequently requires positive-inotropic stimulation. However, there is still no inotropic agent available, which combines a favourable haemodynamic profile with low expenditure for energy metabolism. Pyruvate exhibits positive inotropic effects in vitro and in patients with heart failure. The effect on myocardial energy metabolism however remains unclear, but is meaningful in light of a clinical application.
Aims and methods
We investigated the influence of pyruvate on contractility and oxygen consumption in isolated isometric contracting rabbit myocardium compared to β-adrenergic stimulation with isoproterenol.
Results
Pyruvate (30 mM) increased developed force from 18.7±4.1 to 50.8±12.1 mN/mm2 (n=10, p<0.01). Force-time integral (FTI) increased by 329%, oxygen consumption assessed by diffusion-microelectrode technique increased from 2.86±0.30 mlO2/min*100 g to 6.28±1.28 mlO2/min*100 g (n=7, p<0.05). Economy of myocardial contraction calculated as the ratio of total FTI to oxygen consumption remained unchanged. In contrast, while isoproterenol (10 μM) produced a comparable increase in developed force from 21.4±8.3 to 67.3±15mN/mm2 (n=7, p<0.01), FTI increased only by 260% and MVO2 increased from 2.96±0.43 to 6.12±1.01 mlO2/min*100 g (n=7, p<0.01); thus, economy decreased by 23% (n=7, p<0.05).
Conclusion
Pyruvate does not impair economy of myocardial contraction while isoproterenol decreases economy. Regarding energy expenditure, pyruvate appears superior to isoproterenol for the purpose of positive inotropic stimulation. BACKGROUNDTreatment of acute heart failure frequently requires positive-inotropic stimulation. However, there is still no inotropic agent available, which combines a favourable haemodynamic profile with low expenditure for energy metabolism. Pyruvate exhibits positive inotropic effects in vitro and in patients with heart failure. The effect on myocardial energy metabolism however remains unclear, but is meaningful in light of a clinical application.AIMS AND METHODSWe investigated the influence of pyruvate on contractility and oxygen consumption in isolated isometric contracting rabbit myocardium compared to beta-adrenergic stimulation with isoproterenol.RESULTSPyruvate (30 mM) increased developed force from 18.7+/-4.1 to 50.8+/-12.1 mN/mm2 (n=10, p<0.01). Force-time integral (FTI) increased by 329%, oxygen consumption assessed by diffusion-microelectrode technique increased from 2.86+/-0.30 mlO2/min*100 g to 6.28+/-1.28 mlO2/min*100 g (n=7, p<0.05). Economy of myocardial contraction calculated as the ratio of total FTI to oxygen consumption remained unchanged. In contrast, while isoproterenol (10 microM) produced a comparable increase in developed force from 21.4+/-8.3 to 67.3+/-15 mN/mm2 (n=7, p<0.01), FTI increased only by 260% and MVO2 increased from 2.96+/-0.43 to 6.12+/-1.01 mlO2/min*100 g (n=7, p<0.01); thus, economy decreased by 23% (n=7, p<0.05).CONCLUSIONPyruvate does not impair economy of myocardial contraction while isoproterenol decreases economy. Regarding energy expenditure, pyruvate appears superior to isoproterenol for the purpose of positive inotropic stimulation. Treatment of acute heart failure frequently requires positive-inotropic stimulation. However, there is still no inotropic agent available, which combines a favourable haemodynamic profile with low expenditure for energy metabolism. Pyruvate exhibits positive inotropic effects in vitro and in patients with heart failure. The effect on myocardial energy metabolism however remains unclear, but is meaningful in light of a clinical application. We investigated the influence of pyruvate on contractility and oxygen consumption in isolated isometric contracting rabbit myocardium compared to beta-adrenergic stimulation with isoproterenol. Pyruvate (30 mM) increased developed force from 18.7+/-4.1 to 50.8+/-12.1 mN/mm2 (n=10, p<0.01). Force-time integral (FTI) increased by 329%, oxygen consumption assessed by diffusion-microelectrode technique increased from 2.86+/-0.30 mlO2/min*100 g to 6.28+/-1.28 mlO2/min*100 g (n=7, p<0.05). Economy of myocardial contraction calculated as the ratio of total FTI to oxygen consumption remained unchanged. In contrast, while isoproterenol (10 microM) produced a comparable increase in developed force from 21.4+/-8.3 to 67.3+/-15 mN/mm2 (n=7, p<0.01), FTI increased only by 260% and MVO2 increased from 2.96+/-0.43 to 6.12+/-1.01 mlO2/min*100 g (n=7, p<0.01); thus, economy decreased by 23% (n=7, p<0.05). Pyruvate does not impair economy of myocardial contraction while isoproterenol decreases economy. Regarding energy expenditure, pyruvate appears superior to isoproterenol for the purpose of positive inotropic stimulation. |
| Author | Hermann, Hans-Peter Keweloh, Boris Datz, Nicolin Zeitz, Oliver Janssen, Paul M.L. Siegel, Ulf |
| Author_xml | – sequence: 1 givenname: Boris surname: Keweloh fullname: Keweloh, Boris organization: Franz-Volhard-Klinik, Universitätsklinikum Charité, Berlin, Germany – sequence: 2 givenname: Paul M.L. surname: Janssen fullname: Janssen, Paul M.L. organization: Abteilung Kardiologie und Pneumologie, Universität Göttingen, Göttingen, Germany – sequence: 3 givenname: Ulf surname: Siegel fullname: Siegel, Ulf organization: Abteilung Kardiologie und Pneumologie, Universität Göttingen, Göttingen, Germany – sequence: 4 givenname: Nicolin surname: Datz fullname: Datz, Nicolin organization: Abteilung Kardiologie und Pneumologie, Universität Göttingen, Göttingen, Germany – sequence: 5 givenname: Oliver surname: Zeitz fullname: Zeitz, Oliver organization: Abteilung Kardiologie und Pneumologie, Universität Göttingen, Göttingen, Germany – sequence: 6 givenname: Hans-Peter surname: Hermann fullname: Hermann, Hans-Peter email: phermann@med.uni-goettingen.de organization: Abteilung Kardiologie und Pneumologie, Universität Göttingen, Göttingen, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17532261$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1139_y2012_129 crossref_primary_10_1139_cjpp_2013_0473 crossref_primary_10_1007_s00392_010_0261_4 crossref_primary_10_1016_j_etap_2019_103206 crossref_primary_10_1371_journal_pone_0063608 |
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| Copyright | 2007 European Society of Cardiology 2007 Published on behalf of the European Society of Cardiology. All rights reserved. © 2007 the Authors |
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Treatment of acute heart failure frequently requires positive-inotropic stimulation. However, there is still no inotropic agent available, which... Background Treatment of acute heart failure frequently requires positive‐inotropic stimulation. However, there is still no inotropic agent available, which... Treatment of acute heart failure frequently requires positive-inotropic stimulation. However, there is still no inotropic agent available, which combines a... BACKGROUNDTreatment of acute heart failure frequently requires positive-inotropic stimulation. However, there is still no inotropic agent available, which... |
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| SubjectTerms | Animals Cardiotonic Agents - pharmacology Dose-Response Relationship, Drug energetics Energy Metabolism - drug effects Female heart failure In Vitro Techniques Indoles - pharmacology inotropic therapy Isoproterenol - pharmacology Myocardial Contraction - drug effects Myocardium - metabolism oxygen consumption Oxygen Consumption - drug effects pyruvate Pyruvic Acid - pharmacology Rabbits |
| Title | Influence of pyruvate on economy of contraction in isolated rabbit myocardium |
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