Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period

• Published in: Brain research Vol. 1004; no. 1; pp. 217 - 221
• Main Authors: Soiza-Reilly, Mariano, Fossati, Mariana, Ibarra, Gustavo R., Azcurra, Julio M.
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 09-04-2004; Amsterdam Elsevier; New York, NY
• Subjects: Animals; Biological and medical sciences; Corpus Striatum - growth & development; Corpus Striatum - metabolism; Critical period; Critical Period (Psychology); D1 receptor; D2 receptor; Dopamine; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - physiology; Male; Motor Activity - physiology; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration; Motor plasticity; Rat striatum; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1 - biosynthesis; Receptors, Dopamine D1 - genetics; Receptors, Dopamine D2 - biosynthesis; Receptors, Dopamine D2 - genetics; Vertebrates: nervous system and sense organs; Motor plasticity; Dopamine; D1 receptor; Rat striatum; D2 receptor; Critical period; Motor systems and sensorimotor integration; Rat; Rodentia; Central nervous system; D1 Dopamine receptor; Basal ganglion; Corpus striatum; Encephalon; Locomotion; Vertebrata; Mammalia; Postnatal; D2 Dopamine receptor; Plasticity
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2004.01.050

Circling training during rat striatum postnatal critical period (PN30 to 37 days) induces a life-lasting co-reduction of muscarinic acetylcholine receptors (mAChR) and dopamine D2 receptors (D2R) binding. Here, we evaluated the expression of D1R and D2R under similar experimental conditions. Trained rats showed a decrease of 40% in D2R binding sites (
p<0.01) and of 45% in the D2R mRNA expression which involve short (
p<0.05) and long (
p<0.01) isoforms. In contrast, D1R binding sites nor its mRNA expression levels were affected by training, indicating a differential synaptic refinement during this ontogenetically fixed period.