Evidence for a satellite secretory pathway in neuronal dendritic spines
Long-term information storage within the brain requires the synthesis of new proteins and their use in synapse-specific modifications [1]. Recently, we demonstrated that translation sites for the local synthesis of integral membrane and secretory proteins occur within distal dendritic spines [2]. It...
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| Published in: | Current biology Vol. 11; no. 5; pp. 351 - 355 |
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| Format: | Journal Article |
| Language: | English |
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06-03-2001
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| Abstract | Long-term information storage within the brain requires the synthesis of new proteins and their use in synapse-specific modifications [1]. Recently, we demonstrated that translation sites for the local synthesis of integral membrane and secretory proteins occur within distal dendritic spines [2]. It remains unresolved, however, whether a complete secretory pathway, including Golgi and trans Golgi network-like membranes, exists near synapses for the local transport and processing of newly synthesized proteins. Here, we report evidence of a satellite secretory pathway in distal dendritic spines and distal dendrites of the mammalian brain. Membranes analogous to early (RER and ERGIC), middle (Golgi cisternae), and late (TGN) secretory pathway compartments are present within dendritic spines and in distal dendrites. Local synthesis, processing, and transport of newly translated integral membrane and secretory proteins may thus provide the molecular basis for synapse-specific modifications during long-term information storage in the brain. |
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| AbstractList | Long-term information storage within the brain requires the synthesis of new proteins and their use in synapse-specific modifications [1]. Recently, we demonstrated that translation sites for the local synthesis of integral membrane and secretory proteins occur within distal dendritic spines [2]. It remains unresolved, however, whether a complete secretory pathway, including Golgi and trans Golgi network-like membranes, exists near synapses for the local transport and processing of newly synthesized proteins. Here, we report evidence of a satellite secretory pathway in distal dendritic spines and distal dendrites of the mammalian brain. Membranes analogous to early (RER and ERGIC), middle (Golgi cisternae), and late (TGN) secretory pathway compartments are present within dendritic spines and in distal dendrites. Local synthesis, processing, and transport of newly translated integral membrane and secretory proteins may thus provide the molecular basis for synapse-specific modifications during long-term information storage in the brain. Long-term information storage within the brain requires the synthesis of new proteins and their use in synapse-specific modifications. Recently, we demonstrated that translation sites for the local synthesis of integral membrane and secretory proteins occur within distal dendritic spines. It remains unresolved, however, whether a complete secretory pathway, including Golgi and trans Golgi network-like membranes, exists near synapses for the local transport and processing of newly synthesized proteins. Here, we report evidence of a satellite secretory pathway in distal dendritic spines and distal dendrites of the mammalian brain. Membranes analogous to early (RER and ERGIC), middle (Golgi cisternae), and late (TGN) secretory pathway compartments are present within dendritic spines and in distal dendrites. Local synthesis, processing, and transport of newly translated integral membrane and secretory proteins may thus provide the molecular basis for synapse-specific modifications during long-term information storage in the brain. |
| Author | Pierce, Joseph P Mayer, Thomas McCarthy, J.Brian |
| Author_xml | – sequence: 1 givenname: Joseph P surname: Pierce fullname: Pierce, Joseph P organization: Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 411 East 69th Street, New York, NY 10021, USA – sequence: 2 givenname: Thomas surname: Mayer fullname: Mayer, Thomas organization: Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA – sequence: 3 givenname: J.Brian surname: McCarthy fullname: McCarthy, J.Brian email: jbm2001@med.cornell.edu organization: Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 411 East 69th Street, New York, NY 10021, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11267872$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals Biomarkers Dendrites - metabolism Endoplasmic Reticulum, Rough - metabolism Glycoproteins Golgi Apparatus - metabolism Golgi Matrix Proteins Hippocampus - metabolism Hippocampus - ultrastructure Mannose-Binding Lectins Mannosidases - metabolism Membrane Glycoproteins - metabolism Membrane Proteins - metabolism rab GTP-Binding Proteins - metabolism rab1 GTP-Binding Proteins Rats |
| Title | Evidence for a satellite secretory pathway in neuronal dendritic spines |
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